{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:49Z","timestamp":1789025029725,"version":"build-2803163510"},"reference-count":41,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"The Research Council of Norway","doi-asserted-by":"crossref","award":["17\/38297 and 18\/42795"],"award-info":[{"award-number":["17\/38297 and 18\/42795"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Norwegian Coeliac Society","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Liaison Committee for Education, Research and Innovation in Central Norway","award":["288308"],"award-info":[{"award-number":["288308"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,9]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in the Tr\u00f8ndelag Health Study (HUNT) is a population-based cohort study which was established to provide new knowledge about CD that can improve the diagnostics and management, prevent the onset or progression and expand the knowledge about the role of genetics of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The cohort is based on the fourth wave of the population-based HUNT study (HUNT4), Norway, performed during 2017\u20132019, also including linkage to hospital records and the Norwegian Patient Registry (NPR). A total of 54 541 HUNT4 participants with available sera were screened for CD by serology. All seropositive participants were invited to a clinical assessment, including endoscopy with duodenal biopsies, during 2019\u20132023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>A total of 1107 HUNT4 participants (2%) were seropositive for CD and 1048 were eligible for clinical assessment, including biopsy. Of these, 724 participants attended the clinical assessment and 482 were identified with CD. In addition, 371 participants with CD were identified through the hospital records and NPR. In total, 853 participants in HUNT4 with biopsy-verified CD diagnosis were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>All participants in the study will be invited to a follow-up assessment after at least 1\u2009year, including repeated standard serological testing, endoscopy and tissue sampling. The collected data and material will be used to establish the true population-based prevalence of CD. The consequences of CD, including symptoms, deficiencies and comorbidity, will be investigated and possible triggers and predictors, will be studied. With access to serum samples from the previous HUNT surveys in HUNT Biobank, serological signs of CD in prediagnostic samples of seropositive individuals will be used. Genetic studies will identify new CD markers, assess genotype\u2013phenotype links and explore gene\u2013environment correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>\n                      clinicaltrials.gov identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04041622\">NCT04041622<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077131","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T01:12:18Z","timestamp":1704849138000},"page":"e077131","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Coeliac disease in the Tr\u00f8ndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct04041622","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9636-5552","authenticated-orcid":false,"given":"Polina","family":"Lukina","sequence":"first","affiliation":[{"name":"HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Lerv\u00e5g","family":"Andersen","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway"},{"name":"Department of Medicine, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust, Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter Tinbod","family":"Eggen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust, Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Gjertrud","family":"Mj\u00f8nes","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Tr\u00f8ndelag, Norway"},{"name":"Department of Pathology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Tr\u00f8ndelag, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"R\u00f8nne","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Tr\u00f8ndelag, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Bolstad","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Anton","family":"Klaasen","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Iversen","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Centre for Coeliac Disease Research, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway"},{"name":"K.G. Jebsen Centre for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Tr\u00f8ndelag, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomm","family":"Bernklev","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"R&D Department, Vestfold Hospital Trust, T\u00f8nsberg, Vestfold, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-1576","authenticated-orcid":false,"given":"Lars Petter","family":"Jelsness-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"\u00d8stfold University College, Halden, \u00d8stfold, Norway"},{"name":"Department of Gastroenterology, \u00d8stfold Hospital Trust, Kalnes, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Society, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Groningen, Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Lagergren","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Stockholm, Sweden"},{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig Magne","family":"Sollid","sequence":"additional","affiliation":[{"name":"K.G. 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