{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:15:49Z","timestamp":1793330149734,"version":"4.5.0"},"reference-count":77,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fondation Adrienne et Pierre Sommer hosted by Fondation de France","award":["00081239"],"award-info":[{"award-number":["00081239"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["19-CE37-0020"],"award-info":[{"award-number":["19-CE37-0020"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,5,19]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a severe psychiatric disorder associated with frequent relapses and variability in treatment responses. Previous literature suggested that such variability is influenced by premorbid vulnerabilities such as abnormalities of the reward system. Several factors may indicate these vulnerabilities, such as neurocognitive markers (tendency to favour delayed reward, poor cognitive flexibility, abnormal decision process), genetic and epigenetic markers, biological and hormonal markers, and physiological markers.<\/jats:p>\n                    <jats:p>The present study will aim to identify markers that can predict body mass index (BMI) stability 6 months after discharge. The secondary aim of this study will be focused on characterising the biological, genetic, epigenetic and neurocognitive markers of remission in AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>One hundred and twenty-five (n=125) female adult inpatients diagnosed with AN will be recruited and evaluated at three different times: at the beginning of hospitalisation, when discharged and 6\u2009months later. Depending on the BMI at the third visit, patients will be split into two groups: stable remission (BMI\u226518.5\u2009kg\/m\u00b2) or unstable remission (BMI&lt;18.5\u2009kg\/m\u00b2). One hundred (n=100) volunteers will be included as healthy controls.<\/jats:p>\n                    <jats:p>Each visit will consist in self-reported inventories (measuring depression, anxiety, suicidal thoughts and feelings, eating disorders symptoms, exercise addiction and the presence of comorbidities), neurocognitive tasks (Delay Discounting Task, Trail-Making Test, Brixton Test and Slip-of-action Task), the collection of blood samples, the repeated collection of blood samples around a standard meal and MRI scans at rest and while resolving a delay discounting task.<\/jats:p>\n                    <jats:p>Analyses will mainly consist in comparing patients stabilised 6 months later and patients who relapsed during these 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      Investigators will ask all participants to give written informed consent prior to participation, and all data will be recorded anonymously. The study will be conducted according to ethics recommendations from the Helsinki declaration (World Medical Association, 2013). It was registered on clinicaltrials.gov on 25 August 2020 as \u2018Remission Factors in Anorexia Nervosa (REMANO)\u2019, with the identifier\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04560517\">NCT04560517<\/jats:ext-link>\n                      (for more details, see\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT04560517\">https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT04560517<\/jats:ext-link>\n                      ). The present article is based on the latest protocol version from 29 November 2019. The sponsor, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.inserm.fr\/\">https:\/\/www.inserm.fr\/<\/jats:ext-link>\n                      ), is an academic institution responsible for the monitoring of the study, with an audit planned on a yearly basis.\n                    <\/jats:p>\n                    <jats:p>The results will be published after final analysis in the form of scientific articles in peer-reviewed journals and may be presented at national and international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"clinicaltrials.govNCT04560517\">clinicaltrials.govNCT04560517<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077260","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T02:46:16Z","timestamp":1719369976000},"page":"e077260","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing biomarkers of remission in female patients with anorexia nervosa (REMANO): a protocol for a prospective cohort study with a nested case\u2013control study using clinical, neurocognitive, biological, genetic, epigenetic and neuroimaging markers in a French specialised inpatient unit"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct04560517","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Philibert","family":"Duriez","sequence":"first","affiliation":[{"name":"Institute of 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