{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:09:07Z","timestamp":1793264947243,"version":"4.5.0"},"reference-count":17,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"unspecified","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022850","name":"Little Princess Trust","doi-asserted-by":"publisher","award":["No grant award number available."],"award-info":[{"award-number":["No grant award number available."]}],"id":[{"id":"10.13039\/501100022850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011692","name":"Children\u2019s Cancer and Leukaemia Group","doi-asserted-by":"crossref","award":["No grant award number available."],"award-info":[{"award-number":["No grant award number available."]}],"id":[{"id":"10.13039\/100011692","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,9]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>James Lind Alliance Priority Setting Partnership.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>UK health service and community.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Children and survivors of childhood cancer, diagnosed before age 16, their families, friends and professionals who work with this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four hundred and eighty-eight people submitted 1299 potential questions. These were refined into 108 unique questions; 4 were already answered and 3 were under active study, therefore, removed. Three hundred and twenty-seven respondents completed the shortlisting survey. Seventy-one children submitted questions in the children\u2019s surveys, eight children attended a workshop to prioritise these questions. The Top 5 questions from children were taken to the final workshop where 23 questions in total were discussed by 25 participants (young adults, carers and professionals). The top priority was \u2018can we find effective and kinder (less burdensome, more tolerable, with fewer short and long-term effects) treatments for children with cancer, including relapsed cancer?\u2019<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We have identified research priorities for children\u2019s cancer from the perspectives of children, survivors, their families and the professionals who care for them. Questions reflect the breadth of the cancer experience, including diagnosis, relapse, hospital experience, support during\/after treatment and the long-term impact of cancer. These should inform funding of future research as they are the questions that matter most to the people who could benefit from research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077387","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T01:46:11Z","timestamp":1703123171000},"page":"e077387","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Research priorities for children\u2019s cancer: a James Lind Alliance Priority Setting Partnership in the UK"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-6993","authenticated-orcid":false,"given":"Susie","family":"Aldiss","sequence":"first","affiliation":[{"name":"School of Health Sciences, University of Surrey, Guildford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hollis","sequence":"additional","affiliation":[{"name":"Leeds Children's Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"},{"name":"Hull-York Medical School and Centre for Reviews and Dissemination, University of York, York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-0918","authenticated-orcid":false,"given":"Ashley","family":"Ball-Gamble","sequence":"additional","affiliation":[{"name":"Children\u2019s Cancer and Leukaemia Group, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Brownsdon","sequence":"additional","affiliation":[{"name":"Patient Representative on the Children\u2019s Cancer Priority Setting Partnership Steering Group, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Chisholm","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust, Sutton, UK"},{"name":"Institute of Cancer Research Sutton, Sutton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Crowther","sequence":"additional","affiliation":[{"name":"Parent Representative on the Children\u2019s Cancer Priority Setting Partnership Steering Group, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dommett","sequence":"additional","affiliation":[{"name":"Bristol Royal Hospital for Children, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gower","sequence":"additional","affiliation":[{"name":"James Lind Alliance, National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-9374","authenticated-orcid":false,"given":"Nigel J","family":"Hall","sequence":"additional","affiliation":[{"name":"Southampton Children's Hospital, Southampton, UK"},{"name":"University of Southampton Faculty of Medicine, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Hartley","sequence":"additional","affiliation":[{"name":"Alder Hey Children's NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Hatton","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Henry","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust, Sutton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loveday","family":"Langton","sequence":"additional","affiliation":[{"name":"Parent Representative on the Children\u2019s Cancer Priority Setting Partnership Steering Group, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Maddock","sequence":"additional","affiliation":[{"name":"Leeds Children's Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Malik","sequence":"additional","affiliation":[{"name":"Young Lives Vs Cancer, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keeley","family":"McEvoy","sequence":"additional","affiliation":[{"name":"Medical Needs Teaching Service, Leeds Children's Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-8638","authenticated-orcid":false,"given":"Jessica Elizabeth","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"},{"name":"Centre for Reviews and Dissemination, University of York, York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Morris","sequence":"additional","affiliation":[{"name":"Children, Teenage and Young Adult Cancer Operational Delivery Network, South West, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Parke","sequence":"additional","affiliation":[{"name":"Royal Devon and Exeter NHS Foundation Trust, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Picton","sequence":"additional","affiliation":[{"name":"Leeds Children's Hospital, Leeds, 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