{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:32:10Z","timestamp":1740162730607,"version":"3.37.3"},"reference-count":26,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Ministry of Health Zanzibar","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the community\u2019s perception on the magnitude of Xeroderma pigmentosum (XP) disease and healthcare-seeking practices in Micheweni, Pemba in response to the public widespread information on the increased burden of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Mixed-methods cross-sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Micheweni district, Pemba.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>211 male and female adults in the household survey, three caretakers\/parents of patients with XP in the case study, 20 key community leaders\/influential people and health workers in in-depth interviews and 50 community members and other leaders in six focus groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study has revealed that XP disease exists in few families of which some of them have more than one child affected. The record review showed that there were a total of 17 patients who were diagnosed with the disease for the past 3 years, however only 10 were alive during the time of the survey. Findings from the community members revealed that several patients were believed to have XP disease and perceived causes include inheritance, food types, beliefs and other sociocultural practices. Stigma and discrimination were reported by caretakers and religious leaders. However, some cases believed to be XP were identified as other skin conditions when clinical examination was performed by the team of our researchers. There is a great confusion about XP and other skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study has shown that XP affects only few families, hence termed as concentrated rather than a generalised disease. Due to the rareness of the disease, majority of people in the district are unaware of the disease, hence confusing it with other skin conditions. There is a need for the government in collaboration with other stakeholders to provide educational programme to community members about the disease to address the misconception about the magnitude of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077741","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T02:11:52Z","timestamp":1707790312000},"page":"e077741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Community perspectives on the magnitude of Xeroderma pigmentosum and care-seeking practices in Micheweni district, Pemba: a mixed-methods cross-sectional study"],"prefix":"10.1136","volume":"14","author":[{"given":"Lucas E","family":"Matemba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-1784","authenticated-orcid":false,"given":"Elizabeth H","family":"Shayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ame","family":"Masemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahya K","family":"Nassor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayassa S","family":"Ally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-2428","authenticated-orcid":false,"given":"Judith","family":"Msovela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"2024021218103055000_14.2.e077741.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519444113"},{"key":"2024021218103055000_14.2.e077741.2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0015-0282(16)36730-9","article-title":"On the configuration of the plasma membrane of the mature spermatozoon","volume":"19","author":"Zamboni","year":"1968","journal-title":"Fertil Steril"},{"key":"2024021218103055000_14.2.e077741.3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160715985"},{"key":"2024021218103055000_14.2.e077741.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.01.014"},{"key":"2024021218103055000_14.2.e077741.5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/jhg.2009.50","article-title":"High frequency of the V548A fs X572 XPC mutation in Tunisia: implication for molecular diagnosis","volume":"54","author":"Ben Rekaya","year":"2009","journal-title":"J Hum Genet"},{"key":"2024021218103055000_14.2.e077741.6","doi-asserted-by":"crossref","unstructured":"Lehmann AR , McGibbon D , Stefanini M , et al . 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