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This study explored the epidemiology, site-specific characteristics and survival outcome of CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We conducted a retrospective study in the Surveillance, Epidemiology and End Results (SEER) database (1975\u20132018) for primary CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and participants<\/jats:title><jats:p>SEER database includes publicly available information from regional and state cancer registries in the US centres. A total of 5042 CS patients were identified. We selected the top five anatomic CS (uterus, double adnexa, lung, bladder and breast) patients for further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Primary outcome measures<\/jats:title><jats:p>Incidence was estimated by geographical region, age, sex, race, stage and primary site. Trends were calculated using joinpoint regression. The cancer-specific survival (CSS) rate and initial treatment were summarised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly 80% of CS occurred in the uterus and double adnexa, followed by lung, bladder and breast. The elderly and black population presented the highest age-adjusted rate of CS. The rates of distant metastasis in CS progressively increased from 1989 to 2018. Atlanta was the area with the highest incidence at 0.7 per 100 000. Pulmonary and bladder CS more frequently occurred in men and were diagnosed with regional stage. Distant metastasis was mostly found in ovary\/fallopian tube CS. Radiotherapy was more commonly applied in uterine CS, while adnexa CS cases were more likely to receive chemotherapy. Multiple treatments were more used in breast CS. Pulmonary CS seemed to suffer worse CSS (median: 9.92 months), for which radiotherapy might not provide survival benefits (HR 0.60, 95% CI 0.42 to 0.86). Compared with the common histological types in each site, CS had the shortest survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CS has unique clinical features in each primary site. Substantial prognosis variances exist based on tumour locations. The aggressive course is the common feature in CS at all sites.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077974","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T07:07:10Z","timestamp":1702624030000},"page":"e077974","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-7463","authenticated-orcid":false,"given":"Lian-Sha","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-5481","authenticated-orcid":false,"given":"Ji-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"2023121423051458000_13.12.e077974.1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s13691-020-00462-y","article-title":"Experience of the Pancreas Duodenectomy for so-called Carcinosarcoma of the common bile duct:a case report and review of literature","volume":"10","author":"Sasamoto","year":"2021","journal-title":"Int Cancer Conf J"},{"key":"2023121423051458000_13.12.e077974.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9523"},{"key":"2023121423051458000_13.12.e077974.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.008"},{"key":"2023121423051458000_13.12.e077974.4","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000630"},{"key":"2023121423051458000_13.12.e077974.5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3233\/BD-170313","article-title":"Metaplastic carcinoma of the breast with Mesenchymal differentiation (Carcinosarcoma). 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