{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:51:28Z","timestamp":1793962288619,"version":"4.8.0"},"reference-count":50,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Health Research of Cadres in Sichuan province","award":["SCR2022-101"],"award-info":[{"award-number":["SCR2022-101"]}]},{"name":"Sichuan Science and Technology Program","award":["2022YFS0295, 2022YFG0205, 2023ZYD0173"],"award-info":[{"award-number":["2022YFS0295, 2022YFG0205, 2023ZYD0173"]}]},{"name":"1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University","award":["ZYJC21005"],"award-info":[{"award-number":["ZYJC21005"]}],"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2020YFC2009004"],"award-info":[{"award-number":["2020YFC2009004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,2,16]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aims to provide an estimate of sarcopenia prevalence and its impact on clinical characteristics in patients with systemic sclerosis (SSc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>Embase, Medline, Web of Science and the Cochrane Central Register of Controlled Trials were systemically searched from inception to 24 May 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria for selecting studies<\/jats:title>\n                    <jats:p>We included observational studies that reported the prevalence of sarcopenia in patients with SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction and synthesis<\/jats:title>\n                    <jats:p>Two reviewers independently performed study selection and data extraction using standardised methods. Risk of bias was assessed using the Agency for Healthcare Research and Quality Scale and the Newcastle\u2013Ottawa Scale. Meta-analysis was conducted using random effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4583 articles were screened and 9 studies with data from 815 patients were included in the analysis (8 cross-sectional studies and 1 retrospective cohort study). The overall prevalence of sarcopenia in patients with SSc was 22% (95% CI 17% to 28%). Patients with SSc with sarcopenia had a poorer quality of life (mean difference \u221212.02; 95%\u2009CI \u221219.11 to \u22124.93) and higher C reactive protein (CRP) levels (standardised mean difference 0.67; 95%\u2009CI 0.35 to 1.00).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia is common in patients with SSc. Patients with SSc with sarcopenia had a worse quality of life and higher CRP levels, based on our findings. Given the detrimental impact of sarcopenia on quality of life, future efforts aimed at early identification of sarcopenia in the clinical assessment of patients with SSc may have significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42022368326.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-078034","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:40:11Z","timestamp":1709685611000},"page":"e078034","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Sarcopenia in systemic sclerosis: prevalence and impact\u2014a systematic review and meta-analysis"],"prefix":"10.1136","volume":"14","author":[{"given":"Xiangping","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ju","sequence":"additional","affiliation":[{"name":"Sichuan University Library, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-779X","authenticated-orcid":false,"given":"Jirong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2025120619014790000_14.3.e078034.1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"The Lancet"},{"key":"2025120619014790000_14.3.e078034.2","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/1756-185X.13716","article-title":"Prevalence and incidence of systemic sclerosis: a systematic review and meta-analysis","volume":"22","author":"Zhong","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"2025120619014790000_14.3.e078034.3","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, Subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J Rheumatol"},{"key":"2025120619014790000_14.3.e078034.4","doi-asserted-by":"crossref","first-page":"110999","DOI":"10.1016\/j.nut.2020.110999","article-title":"Evaluating skeletal muscle mass with ultrasound in patients with systemic sclerosis","volume":"84","author":"Sari","year":"2021","journal-title":"Nutrition"},{"key":"2025120619014790000_14.3.e078034.5","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00296-019-04401-w","article-title":"Sarcopenia in systemic sclerosis: the impact of nutritional, clinical, and laboratory features","volume":"39","author":"Corallo","year":"2019","journal-title":"Rheumatol Int"},{"key":"2025120619014790000_14.3.e078034.6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nut.2018.03.046","article-title":"Prevalence of sarcopenia in systemic sclerosis: assessing body composition and functional disability in patients with systemic sclerosis","volume":"55\u201356","author":"Siegert","year":"2018","journal-title":"Nutrition"},{"key":"2025120619014790000_14.3.e078034.7","first-page":"65","article-title":"Advanced microvascular damage associated with occurrence of sarcopenia in systemic sclerosis patients: results from a retrospective cohort study","volume":"38","author":"Paolino","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"2025120619014790000_14.3.e078034.8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/03009740903555358","article-title":"Impaired exercise performance in systemic sclerosis and its clinical correlations","volume":"39","author":"Cuomo","year":"2010","journal-title":"Scand J Rheumatol"},{"key":"2025120619014790000_14.3.e078034.9","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"2025120619014790000_14.3.e078034.10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12603-019-1267-x","article-title":"Differences in the prevalence of Sarcopenia in community-dwelling, nursing home and hospitalized individuals","volume":"24","author":"Papadopoulou","year":"2020","journal-title":"J Nutr Health Aging"},{"key":"2025120619014790000_14.3.e078034.11","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"The Lancet"},{"key":"2025120619014790000_14.3.e078034.12","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10067-017-3932-y","article-title":"Malnutrition and sarcopenia in a large cohort of patients with systemic sclerosis","volume":"37","author":"Caimmi","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2025120619014790000_14.3.e078034.13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245683","article-title":"Practical screening tools for sarcopenia in patients with systemic sclerosis","volume":"16","author":"Hax","year":"2021","journal-title":"PLoS ONE"},{"key":"2025120619014790000_14.3.e078034.14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21914-w","article-title":"Prevalence and clinical Association of sarcopenia among Thai patients with systemic sclerosis","volume":"12","author":"Sangaroon","year":"2022","journal-title":"Sci Rep"},{"key":"2025120619014790000_14.3.e078034.15","first-page":"2957","article-title":"Sarcopenia in systemic sclerosis","volume":"71","author":"Rinc\u00f3n","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2025120619014790000_14.3.e078034.16","first-page":"S1","article-title":"The frequency of sarcopenia and factors associated with muscle mass in women with systemic scleroderma (pilot study)","volume":"32","author":"Efremova","year":"2022","journal-title":"Osteoporos Int"},{"key":"2025120619014790000_14.3.e078034.17","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"2025120619014790000_14.3.e078034.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"2025120619014790000_14.3.e078034.19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2025120619014790000_14.3.e078034.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"2025120619014790000_14.3.e078034.21","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"2025120619014790000_14.3.e078034.22","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"2025120619014790000_14.3.e078034.23","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or Interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"2025120619014790000_14.3.e078034.24","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12141"},{"key":"2025120619014790000_14.3.e078034.25","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"2025120619014790000_14.3.e078034.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"2025120619014790000_14.3.e078034.27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"2025120619014790000_14.3.e078034.28","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2019.6.23917"},{"key":"2025120619014790000_14.3.e078034.29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jss.2018.10.048","article-title":"The influence of sarcopenia on high-risk neuroblastoma","volume":"236","author":"Kawakubo","year":"2019","journal-title":"J Surg Res"},{"key":"2025120619014790000_14.3.e078034.30","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13133"},{"key":"2025120619014790000_14.3.e078034.31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.maturitas.2019.01.006","article-title":"Age-related bone loss and sarcopenia in men","volume":"122","author":"Laurent","year":"2019","journal-title":"Maturitas"},{"issue":"3 Suppl 29","key":"2025120619014790000_14.3.e078034.32","first-page":"S15","article-title":"Assessment of gastrointestinal involvement","volume":"21","author":"Clements","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2025120619014790000_14.3.e078034.33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76185-0","article-title":"Prevalence and risk factors of sarcopenia in community-dwelling older adults visiting regional medical institutions from the Kadoma Sarcopenia study","volume":"10","author":"Kurose","year":"2020","journal-title":"Sci Rep"},{"key":"2025120619014790000_14.3.e078034.34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101122","article-title":"Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis","volume":"25","author":"Doridot","year":"2019","journal-title":"Redox Biol"},{"key":"2025120619014790000_14.3.e078034.35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11041509"},{"key":"2025120619014790000_14.3.e078034.36","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00133.2007"},{"key":"2025120619014790000_14.3.e078034.37","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051104","article-title":"Cytokines involved in the pathogenesis of SSC and problems in the development of anti-cytokine therapy","volume":"10","author":"Shima","year":"2021","journal-title":"Cells"},{"key":"2025120619014790000_14.3.e078034.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.006"},{"key":"2025120619014790000_14.3.e078034.39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00296-017-3879-y","article-title":"Physical activity in patients with systemic sclerosis","volume":"38","author":"Liem","year":"2018","journal-title":"Rheumatol Int"},{"key":"2025120619014790000_14.3.e078034.40","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57379-3_19"},{"key":"2025120619014790000_14.3.e078034.41","doi-asserted-by":"crossref","DOI":"10.1186\/2049-3258-72-45","article-title":"Sarcopenia: burden and challenges for public health","volume":"72","author":"Beaudart","year":"2014","journal-title":"Arch Public Health"},{"key":"2025120619014790000_14.3.e078034.42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2012.00851.x"},{"key":"2025120619014790000_14.3.e078034.43","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"2025120619014790000_14.3.e078034.44","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"2025120619014790000_14.3.e078034.45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2003"},{"key":"2025120619014790000_14.3.e078034.46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00223-013-9830-7","article-title":"Total and appendicular lean mass reference ranges for Australian men and women: the Geelong osteoporosis study","volume":"94","author":"Gould","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"2025120619014790000_14.3.e078034.47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113637","article-title":"Grip strength across the life course: normative data from twelve British studies","volume":"9","author":"Dodds","year":"2014","journal-title":"PLoS One"},{"key":"2025120619014790000_14.3.e078034.48","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-016-0763-7","article-title":"Short physical performance battery and all-cause mortality: systematic review and meta-analysis","volume":"14","author":"Pavasini","year":"2016","journal-title":"BMC Med"},{"key":"2025120619014790000_14.3.e078034.49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.02126.x"},{"key":"2025120619014790000_14.3.e078034.50","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-078034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:01:57Z","timestamp":1765076517000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-078034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,5]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bmjopen-2023-078034"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-078034","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}