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However, the effects of such interventions to tentatively prevent secondary neurological damages have never been assessed in infants with CP. This study aims to determine the effect of the baby Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (baby HABIT-ILE) in infants with unilateral CP, compared with a control intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This randomised controlled trial will include 48 infants with unilateral CP aged (corrected if preterm) 6\u201318 months at the first assessment. They will be paired by age and by aetiology of the CP, and randomised into two groups (immediate and delayed). Assessments will be performed at baseline and at 1\u2009month, 3 months and 6 months after baseline. The immediate group will receive 50 hours of baby HABIT-ILE intervention over 2 weeks, between first and second assessment, while the delayed group will continue their usual activities. This last group will receive baby HABIT-ILE intervention after the 3-month assessment. Primary outcome will be the Mini-Assisting Hand Assessment. Secondary outcomes will include behavioural assessments for gross and fine motricity, visual\u2013cognitive\u2013language abilities as well as MRI and kinematics measures. Moreover, parents will determine and score child-relevant goals and fill out questionnaires of participation, daily activities and mobility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      Full ethical approval has been obtained by the\n                      <jats:italic>Comit\u00e9 d\u2019\u00e9thique Hospitalo-Facultaire\/Universit\u00e9 catholique de Louvain<\/jats:italic>\n                      , Brussels (2013\/01MAR\/069 B403201316810g). The recommendations of the ethical board and the Belgian law of 7 May 2004 concerning human experiments will be followed. Parents will sign a written informed consent ahead of participation. Findings will be published in peer-reviewed journals and conference presentations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04698395\">NCT04698395<\/jats:ext-link>\n                      . Registered on the International Clinical Trials Registry Platform (ICTRP) on 2 December 2020 and NIH Clinical Trials Registry on 6 January 2021. URL of trial registry record:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04698395?term=bleyenheuft&amp;draw=1&amp;rank=7\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04698395?term=bleyenheuft&amp;draw=1&amp;rank=7<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-078383","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T06:05:27Z","timestamp":1708149927000},"page":"e078383","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Baby HABIT-ILE intervention: study protocol of a randomised controlled trial in infants aged 6\u201318 months with unilateral cerebral palsy"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct04698395","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04698395","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2409-8711","authenticated-orcid":false,"given":"Astrid","family":"Carton de Tournai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1042-7985","authenticated-orcid":false,"given":"Enimie","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-2420","authenticated-orcid":false,"given":"Estelle","family":"Gathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-8706","authenticated-orcid":false,"given":"Daniela","family":"Ebner-Karestinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-5504","authenticated-orcid":false,"given":"Rodrigo","family":"Araneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8613-2420","authenticated-orcid":false,"given":"Laurence","family":"Dricot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-4778","authenticated-orcid":false,"given":"Beno\u00eet","family":"Macq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Vandermeeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-932X","authenticated-orcid":false,"given":"Yannick","family":"Bleyenheuft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"2024021703050696000_14.2.e078383.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.82"},{"key":"2024021703050696000_14.2.e078383.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00144.x"},{"key":"2024021703050696000_14.2.e078383.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61229-0"},{"key":"2024021703050696000_14.2.e078383.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61013-7"},{"key":"2024021703050696000_14.2.e078383.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2006.00634.x"},{"key":"2024021703050696000_14.2.e078383.6","doi-asserted-by":"crossref","unstructured":"Te Velde A , Morgan C , Finch-Edmondson M , et al . 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