{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:11:21Z","timestamp":1765825881647,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"unspecified","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81674037"],"award-info":[{"award-number":["81674037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sichuan Science and Technology Support Program","award":["2022YFS0421"],"award-info":[{"award-number":["2022YFS0421"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,10,3]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis (CRS) is a common chronic disease that seriously affects patients\u2019 quality of life and imposes a heavy physical and mental burden on patients. There is growing evidence that sleep disorders are strongly associated with patients with CRS. However, there is no systematic evidence to clarify the prevalence and influencing factors of sleep disorders in patients with CRS with nasal polyps (NP) (CRSwNP) and CRS without NP (CRSsNP). For this reason, this study will systematically analyse the prevalence of sleep disorders in patients with CRSwNP and CRSsNP and explore the related influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will electronically search PubMed, Web of Science, Embase, Cochrane, Ovid, Scopus, the China National Knowledge Infrastructure, the Wanfang database, the China Biomedical Literature Database and the China Scientific Journals Database from the establishment of the database to September 2023 to collect the prevalence of sleep disorders in patients with CRSwNP or CRSsNP and related studies on factors affecting sleep disorders. Two researchers will independently conduct literature screening and data extraction and evaluate the quality of the included studies using the Newcastle-Ottawa Quality Scale and Agency for Healthcare Research and Quality scales. The extracted data will be meta-analysed using Review Manager 5.3 and Stata 14.0 software, and the quality of the evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation. Publication bias will be assessed using the funnel plots, Egger\u2019s test and Begg\u2019s test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This review will not require ethical approval, as we will only use research data from the published documents. Our final findings will be published in a peer-reviewed, open-access journal for dissemination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42023446833.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-078430","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T08:51:40Z","timestamp":1703926300000},"page":"e078430","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and influencing factors of sleep disorders in patients with CRS: a protocol for systematic review and meta-analysis"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-9142","authenticated-orcid":false,"given":"Yuqi","family":"Wu","sequence":"first","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijie","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiong","family":"He","sequence":"additional","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-1875","authenticated-orcid":false,"given":"Hongli","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhoutong","family":"Han","sequence":"additional","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TianMin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"2025121511063666000_13.12.e078430.1","first-page":"500","article-title":"Chronic rhinosinusitis","volume":"96","author":"Sedaghat","year":"2017","journal-title":"Am Fam Physician"},{"key":"2025121511063666000_13.12.e078430.2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"2025121511063666000_13.12.e078430.3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.jaip.2022.01.016","article-title":"Epidemiology of chronic rhinosinusitis: prevalence and risk factors","volume":"10","author":"Sedaghat","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025121511063666000_13.12.e078430.4","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/lary.29405","article-title":"Pain catastrophizing and quality of life in adults with chronic rhinosinusitis","volume":"131","author":"Kazi","year":"2021","journal-title":"Laryngoscope"},{"key":"2025121511063666000_13.12.e078430.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.037"},{"key":"2025121511063666000_13.12.e078430.6","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24630"},{"key":"2025121511063666000_13.12.e078430.7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/14787210.2017.1294063","article-title":"Sleep disruption in chronic rhinosinusitis","volume":"15","author":"Mahdavinia","year":"2017","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2025121511063666000_13.12.e078430.8","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21217"},{"key":"2025121511063666000_13.12.e078430.9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/alr.22212","article-title":"Impact of chronic rhinosinusitis on sleep: a controlled clinical study","volume":"9","author":"Alt","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"2025121511063666000_13.12.e078430.10","unstructured":"Institute of Medicine Committee on Sleep M, Research . The National academies collection: reports funded by National Institutes of health. In: Colten HR , Altevogt BM , eds. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington (DC): National Academies Press (US) Copyright \u00a9 2006, National Academy of Sciences, 2006."},{"key":"2025121511063666000_13.12.e078430.11","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/lary.24040","article-title":"Sleep quality and disease severity in patients with chronic rhinosinusitis","volume":"123","author":"Alt","year":"2013","journal-title":"Laryngoscope"},{"key":"2025121511063666000_13.12.e078430.12","doi-asserted-by":"crossref","unstructured":"Bengtsson C , Lindberg E , Jonsson L , et al . Chronic rhinosinusitis impairs sleep quality: results of the GA2LEN study. 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