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The objective is to estimate the incidence of anterior pituitary dysfunction in adults undergoing radiotherapy for head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>A total of five databases will be used to perform the document search: PubMed, Scopus, Web of Science (Core Collection), Ovid-MEDLINE and Embase. Cohort studies will be included without restriction by language or date. The main outcome will be the incidence of adenohypophyseal dysfunction for each axis: prolactin, growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, luteinising hormone and follicle-stimulating hormone. Incidence meta-analysis will be performed using the Freeman-Tukey double arcsine method. In addition, a random-effects model will be used along with a 95% CI. Subgroup analyses will be performed according to tumour location, radiation dose and endocrine assessment time. Meta-regression will be applied according to patient\u2019s age and time elapsed until diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and disclosure<\/jats:title><jats:p>Since this will be a systematic review of published data, no ethics committee approval is required. The results will be presented at conferences and finally published in a peer-reviewed journal.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42021235163.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-078595","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T17:51:34Z","timestamp":1712166694000},"page":"e078595","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of hypopituitarism in adults undergoing radiotherapy for neck and head cancer: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"14","author":[{"given":"Shamir","family":"Barros-Sevillano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Cabanillas-Lazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franshesca L","family":"Sedano-Chiroque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Escajadillo-Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2531","authenticated-orcid":false,"given":"David","family":"Espinoza-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Pinedo-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"2024040310501277000_14.4.e078595.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61396-9"},{"key":"2024040310501277000_14.4.e078595.2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-008-0088-4"},{"key":"2024040310501277000_14.4.e078595.3","unstructured":"Pekic S , Miljic D , Popovic V , et al . 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