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Our study will investigate if an anti-inflammatory dietary programme is superior to a standard care low-fat dietary programme for improving knee pain, function and quality-of-life in people with knee osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      The eFEct of an Anti-inflammatory diet for knee oSTeoarthritis study is a parallel-group, assessor-blinded, superiority randomised controlled trial. Following baseline assessment, 144 participants aged 45\u201385 years with symptomatic knee osteoarthritis will be randomly allocated to one of two treatment groups (1:1 ratio). Participants randomised to the anti-inflammatory dietary programme will receive six dietary consultations over 12 weeks (two in-person and four phone\/videoconference) and additional educational and behaviour change resources. The consultations and resources emphasise nutrient-dense minimally processed anti-inflammatory foods and discourage proinflammatory processed foods. Participants randomised to the standard care low-fat dietary programme will receive three dietary consultations over 12 weeks (two in-person and one phone\/videoconference) consisting of healthy eating advice and education based on the Australian Dietary Guidelines, reflecting usual care in Australia. Adherence will be assessed with 3-day food diaries. Outcomes are assessed at 12 weeks and 6 months. The primary outcome will be change from baseline to 12 weeks in the mean score on four Knee injury and Osteoarthritis Outcome Score (KOOS\n                      <jats:sub>4<\/jats:sub>\n                      ) subscales: knee pain, symptoms, function in daily activities and knee-related quality of life. Secondary outcomes include change in individual KOOS subscale scores, patient-perceived improvement, health-related quality of life, body mass and composition using dual-energy X-ray absorptiometry, inflammatory (high-sensitivity C reactive protein, interleukins, tumour necrosis factor-\u03b1) and metabolic blood biomarkers (glucose, glycated haemoglobin (HbA1c), insulin, liver function, lipids), lower-limb function and physical activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study has received ethics approval from La Trobe University Human Ethics Committee. Results will be presented in peer-reviewed journals and at international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12622000440729.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-079374","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:41:03Z","timestamp":1712101263000},"page":"e079374","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of an anti-inflammatory diet versus low-fat diet for knee osteoarthritis: the FEAST randomised controlled trial protocol"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-9636","authenticated-orcid":false,"given":"Lynette","family":"Law","sequence":"first","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L","family":"Heerey","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L","family":"Devlin","sequence":"additional","affiliation":[{"name":"School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brukner","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-1923","authenticated-orcid":false,"given":"Joanne L","family":"Kemp","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Attanayake","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Hulett","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysha","family":"De Livera","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia"},{"name":"School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B","family":"Mosler","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden G","family":"Morris","sequence":"additional","affiliation":[{"name":"Melbourne Knee Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P","family":"White","sequence":"additional","affiliation":[{"name":"Melbourne Knee Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-0264","authenticated-orcid":false,"given":"Adam G","family":"Culvenor","sequence":"additional","affiliation":[{"name":"La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"2025121515174401000_14.4.e079374.1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100587","article-title":"Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies","volume":"29\u201330","author":"Cui","year":"2020","journal-title":"EClinicalMedicine"},{"key":"2025121515174401000_14.4.e079374.2","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1001\/jama.2023.19675","article-title":"Evaluation and treatment of knee pain","volume":"330","author":"Duong","year":"2023","journal-title":"JAMA"},{"key":"2025121515174401000_14.4.e079374.3","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-105898"},{"key":"2025121515174401000_14.4.e079374.4","unstructured":"Ackerman I , Bohensky M , Pratt C , et al . 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