{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:52:43Z","timestamp":1790923963909,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"He Eye Specialist Hospital","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,29]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Assessment of near work-induced transient myopia (NITM) is important for permanent myopia development and progression. Atropine eye drop has been reported to be beneficial in reducing initial NITM and slowing down myopic progression. This study aimed to investigate the efficacy of 0.01% atropine in treating NITM and its possible association with the progression of refractive change in Chinese myopic children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The study is designed as a parallel assignment prospective, randomised, double-blinded, placebo-controlled trial conducted at He Eye Specialist Hospital in Shenyang, China. One hundred fifty participants will be randomly assigned in a 1:1 ratio to receive 0.01% atropine or placebo eye drop once nightly bilaterally for 1 year. Initial NITM, cycloplegic refraction, axial length, best-corrected visual acuity, intraocular pressure and pupil diameter will be measured at baseline, 4\u2009weeks, 12\u2009weeks, 24\u2009weeks, 36\u2009weeks and 48\u2009weeks. Visual Function Questionnaire will be administered at baseline and each follow-up visit. Adverse events also will be monitored and documented at each subsequent follow-up visit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>A parallel assignment prospective, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy of 0.01% atropine for near work-induced transient myopia and myopic progression registered on 10 September 2023. Ethics approval number: IRB (2023) K025.01. The study\u2019s findings will be shared regardless of the effect\u2019s direction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06034366\">NCT06034366<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-079833","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T01:46:06Z","timestamp":1703123166000},"page":"e079833","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Protocol for a parallel assignment prospective, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy of 0.01% atropine for near work-induced transient myopia and myopic progression in China"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct06034366","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06034366","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06034366","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Guanghao","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"},{"name":"College of Public Health, He University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sile","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"},{"name":"College of Public Health, He University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-827X","authenticated-orcid":false,"given":"Emmanuel Eric","family":"Pazo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingru","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, China"},{"name":"College of Public Health, He University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"2025101813102058000_13.12.e079833.1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2025101813102058000_13.12.e079833.2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3455"},{"key":"2025101813102058000_13.12.e079833.3","unstructured":"Wong TY , Foster PJ , Hee J , et al . Prevalence and risk factors for refractive errors in adult Chinese in Singapore. Invest Ophthalmol Vis Sci 2000;41."},{"key":"2025101813102058000_13.12.e079833.4","first-page":"1797","article-title":"Myopes show increased susceptibility to nearwork aftereffects","volume":"39","author":"Ciuffreda","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025101813102058000_13.12.e079833.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2006.10.004"},{"key":"2025101813102058000_13.12.e079833.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2008.00550.x"},{"key":"2025101813102058000_13.12.e079833.7","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.24.4.289.8418"},{"key":"2025101813102058000_13.12.e079833.8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/OPX.0b013e31828deef1","article-title":"Nearwork-induced transient myopia and parental refractive error","volume":"90","author":"Lin","year":"2013","journal-title":"Optom Vis Sci"},{"key":"2025101813102058000_13.12.e079833.9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.optom.2020.05.004","article-title":"The association between nearwork-induced transient myopia and progression of refractive error: a 3-year cohort report from Beijing myopia progression study","volume":"14","author":"Lin","year":"2021","journal-title":"J Optom"},{"key":"2025101813102058000_13.12.e079833.10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0373"},{"key":"2025101813102058000_13.12.e079833.11","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ophtha.2021.10.002","article-title":"Three-year clinical trial of low-concentration atropine for myopia progression (LAMP) study: continued versus washout: phase 3 report","volume":"129","author":"Yam","year":"2022","journal-title":"Ophthalmology"},{"key":"2025101813102058000_13.12.e079833.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.12.011"},{"key":"2025101813102058000_13.12.e079833.13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/jop.2019.0062","article-title":"Use of topical 0.01% atropine for controlling near work-induced transient myopia: A randomized, double-masked, placebo-controlled study","volume":"36","author":"Guo","year":"2020","journal-title":"J Ocul Pharmacol Ther"},{"key":"2025101813102058000_13.12.e079833.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials","volume":"346","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"2025101813102058000_13.12.e079833.15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/08164622.2022.2029684","article-title":"Impact of dual-focus soft contact lens wear on near work-induced transient myopia","volume":"106","author":"Jim\u00e9nez","year":"2023","journal-title":"Clin Exp Optom"},{"key":"2025101813102058000_13.12.e079833.16","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.158428"},{"key":"2025101813102058000_13.12.e079833.17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-052488","article-title":"Clinical efficacy of Diquafosol sodium 3% versus Hyaluronic acid 0.1% in patients with dry eye disease after cataract surgery: a protocol for a single-centre, randomised controlled trial","volume":"12","author":"Miura","year":"2022","journal-title":"BMJ Open"},{"key":"2025101813102058000_13.12.e079833.18","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-073055","article-title":"Protocol for a parallel assignment prospective, randomised, comparative trial to evaluate the safety and efficacy of intense pulsed light (IPL) combined with 3% Diquafosol (DQS) ophthalmic solution in dry eye syndrome","volume":"13","author":"Chen","year":"2023","journal-title":"BMJ Open"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-079833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:10:29Z","timestamp":1760818229000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-079833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,20]]},"published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1136\/bmjopen-2023-079833"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-079833","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}