{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:08:20Z","timestamp":1775106500762,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Boston Scientific Limited","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,4,15]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) is a promising new ablation modality for the treatment of atrial fibrillation (AF) that has recently become available in the UK National Health Service (NHS). We provide the first known economic evaluation of the technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cost-comparison model was developed to compare the expected 12-month costs of treating AF using the pentaspline PFA catheter compared with cryoablation for a single hypothetical patient. Model parameters were based on a recent cost-effectiveness analysis by the National Institute for Health and Care Excellence where possible or published literature otherwise. Deterministic sensitivity, scenario and threshold analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Costs for a single patient treated with PFA were \u22123% (\u2212\u00a3343) less over 12 months than those who received treatment with cryoablation. PFA was associated with 16% higher catheter costs but repeat ablation costs were over 50% less, driven by a reduction in repeat ablations required. Costs of managing complications were \u2212\u00a3211 less in total for PFA compared with cryoablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routine adoption of PFA with the pentaspline PFA catheter looks to be as affordable for the NHS as current treatment alternative cryoablation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-079881","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T14:51:14Z","timestamp":1715266274000},"page":"e079881","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Pulsed field ablation with the pentaspline catheter compared with cryoablation for the treatment of paroxysmal atrial fibrillation in the UK NHS: a cost-comparison analysis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0690-8784","authenticated-orcid":false,"given":"Claire","family":"Duxbury","sequence":"first","affiliation":[{"name":"Health Economics & Market Access, Boston Scientific Limited, Hemel Hempstead, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-974X","authenticated-orcid":false,"given":"David","family":"Begley","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7960-466X","authenticated-orcid":false,"given":"Patrick M","family":"Heck","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"2025121512452305000_14.5.e079881.1","unstructured":"NHS Digital . Quality and outcomes framework, 2021-22: prevalence, achievement and Personalised care adjustments at regional and national level. 2022. Available: https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/quality-and-outcomes-framework-achievement-prevalence-and-exceptions-data\/2021-22"},{"key":"2025121512452305000_14.5.e079881.2","unstructured":"NHS England . Clinical Commissioning Policy: Catheter ablation for paroxysmal and persistent atrial fibrillation (adults), 2022. Available: https:\/\/www.england.nhs.uk\/wp-content\/uploads\/2022\/12\/1903-Clinical-Commissioning-Policy-Catheter-ablation-paroxysmal-persistent-atrial-fibrillation.pdf"},{"key":"2025121512452305000_14.5.e079881.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"2025121512452305000_14.5.e079881.4","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa093"},{"key":"2025121512452305000_14.5.e079881.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"2025121512452305000_14.5.e079881.6","unstructured":"National Institute of Health and Care Excellence . NICE guideline Ng196, atrial fibrillation: diagnosis and management. 2021. 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British Heart Rhythm Society Standards for Interventional Electrophysiology Study and Catheter Ablation in Adults, April 2020, 2020. Available: https:\/\/bhrs.com\/wp-content\/uploads\/2020\/04\/British-Heart-Rhythm-Society-Standards-Ablation-2020-1.pdf"},{"key":"2025121512452305000_14.5.e079881.17","unstructured":"Farapulse Inc . Farawave pulsed field ablation catheter: instructions for use. LBL 1067 Rev C (EU) EN FR DE CS. 2020."},{"key":"2025121512452305000_14.5.e079881.18","unstructured":"National Institute of Health and Care Excellence . NICE guideline Ng196, atrial fibrillation: diagnosis and management, Appendix J3 cost-effectiveness analysis, April 2021. 2021. 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