{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:51Z","timestamp":1792787271277,"version":"4.5.0"},"reference-count":37,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"4DMedical"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,1,7]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cystic fibrosis (CF) is a life-limiting autosomal recessive genetic condition. It is caused by mutations in the gene that encodes for a chloride and bicarbonate conducting transmembrane channel. X-ray velocimetry (XV) is a novel form of X-ray imaging that can generate lung ventilation data through the breathing cycle. XV technology has been validated in multiple animal models, including the \u03b2-ENaC mouse model of CF lung disease. It has since been assessed in early-phase clinical trials in adult human subjects; however, there is a paucity of data in the paediatric cohort, including in CF. The aim of this pilot study was to investigate the feasibility of performing a single-centre cohort study in paediatric patients with CF and in those with normal lungs to demonstrate the appropriateness of proceeding with further studies of XV in these cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is a cross-sectional, single-centre, pilot study. It will recruit children aged 3\u201318 years to have XV lung imaging performed, as well as paired pulmonary function testing. The study will aim to recruit 20 children without CF with normal lungs and 20 children with CF. The primary outcome will be the feasibility of recruiting children and performing XV testing. Secondary outcomes will include comparisons between XV and current assessments of pulmonary function and structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This project has ethical approval granted by The Women\u2019s and Children\u2019s Hospital Human Research Ethics Committee (HREC ID 2021\/HRE00396). Findings will be disseminated through peer-reviewed publication and conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12623000109606.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080034","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T22:31:58Z","timestamp":1707172318000},"page":"e080034","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Pilot study of paediatric regional lung function assessment via X-ray velocimetry (XV) imaging in children with normal lungs and in children with cystic fibrosis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-0947","authenticated-orcid":false,"given":"Matthew","family":"Bruorton","sequence":"first","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Donnelley","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Goddard","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Sleep Department, Sydney Children's Hospitals Network, Westmead, New South Wales, Australia"},{"name":"University of New South Wales, Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Parsons","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Phillips","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Carson-Chahhoud","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tai","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Respiratory and Sleep Department, Women's and Children's Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"2025121510145554000_14.2.e080034.1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)00576-6"},{"key":"2025121510145554000_14.2.e080034.2","unstructured":"Ahern S et al . 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