{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T19:40:51Z","timestamp":1760816451444,"version":"build-2065373602"},"reference-count":19,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,3,20]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bell\u2019s palsy is an idiopathic peripheral nerve palsy involving the facial nerve. Pregnancy, diabetes mellitus and hypertension are the risk factors for Bell\u2019s palsy. However, the association between hypertensive disorders and Bell\u2019s palsy during pregnancy or the puerperium remains unclear. This systematic review will comprehensively summarise the literature and evaluate the association between Bell\u2019s palsy and hypertensive disorders during pregnancy or the puerperium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>Systematic searches of PubMed, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials will be undertaken using prespecified search strategies. Observational studies (cross-sectional studies, cohort studies, case reports and series case reports) written in English that investigate the association between hypertensive disorders of late pregnancy and Bell\u2019s palsy during pregnancy or the puerperium will be included. Different authors will independently conduct the eligible study selection, perform data extraction and appraise the quality of included studies. Subgroup analysis will be carried out based on the age of pregnant women (\u226435 years old, &gt;35 years old), parity (primipara, multipara) and fetus number (singleton or multiple-gestation pregnancy).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>This review will be based on published literature, and thus there is no requirement for ethics approval. The results of this study will aid in the knowledge of the relationship between Bell\u2019s palsy during pregnancy or the puerperium and hypertensive disorders of late pregnancy. The results of this systematic review will be shared through publication in a peer-reviewed journal with good visibility for the field of obstetrics and presentations at academic conferences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42023422902.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080322","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:06:02Z","timestamp":1715947562000},"page":"e080322","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association between hypertensive disorders and Bell\u2019s palsy in pregnancy: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-7565","authenticated-orcid":false,"given":"Ya-Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"2025101812104139000_14.5.e080322.1","doi-asserted-by":"crossref","DOI":"10.1503\/cmaj.220267","article-title":"Bell palsy","volume":"194","author":"Patel","year":"2022","journal-title":"CMAJ"},{"key":"2025101812104139000_14.5.e080322.2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00006254-200003000-00027","article-title":"Bell palsy complicating pregnancy","volume":"55","author":"Cohen","year":"2000","journal-title":"Obstetrical & Gynecological Survey"},{"key":"2025101812104139000_14.5.e080322.3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/000348947508400402","article-title":"Idiopathic facial paralysis, pregnancy, and the Menstrual cycle","volume":"84","author":"Hilsinger","year":"1975","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2025101812104139000_14.5.e080322.4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/AOG.0000000000000221","article-title":"Bilateral Bell palsy as a presenting sign of Preeclampsia","volume":"124","author":"Vogell","year":"2014","journal-title":"Obstet Gynecol"},{"key":"2025101812104139000_14.5.e080322.5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309563"},{"key":"2025101812104139000_14.5.e080322.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09282-4"},{"key":"2025101812104139000_14.5.e080322.7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1159\/000509682","article-title":"Bell\u2019s palsy in pregnancy: A case series","volume":"12","author":"Leelawai","year":"2020","journal-title":"Case Rep Neurol"},{"key":"2025101812104139000_14.5.e080322.8","doi-asserted-by":"crossref","unstructured":"Tan J , Yang M , Liao Y , et al . 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