{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:03:11Z","timestamp":1765818191489,"version":"3.48.0"},"reference-count":36,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,4,30]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>General practitioners (GPs) were on the front line of the COVID-19 outbreak. Identifying clinical profiles in COVID-19 might improve patient care and enable closer monitoring of at-risk profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify COVID-19 profiles in a population of adult primary care patients, and to determine whether the profiles were associated with negative outcomes and persistent symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting and participants<\/jats:title>\n                    <jats:p>In a prospective multicentre study, 44 GPs from multiprofessional primary care practices in the Paris area of France recruited 340 consecutive adult patients (median age: 47 years) with a confirmed diagnosis of COVID-19 during the first two waves of the epidemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and outcome<\/jats:title>\n                    <jats:p>A latent class (LC) analysis with 11 indicators (clinical signs and symptoms) was performed. The resulting profiles were characterised by a 3-month composite outcome (COVID-19-related hospital admission and\/or death) and persistent symptoms three and 6 months after inclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified six profiles: \u2018paucisymptomatic\u2019 (LC1, 9%), \u2018anosmia and\/or ageusia\u2019 (LC2, 12.9%), \u2018influenza-like syndrome with anosmia and ageusia\u2019 (LC3, 15.5%), \u2018influenza-like syndrome without anosmia or ageusia\u2019 (LC4, 24.5%), \u2018influenza-like syndrome with respiratory impairment\u2019 (LC5) and a \u2018complete form\u2019 (LC6, 17.7%). At 3 months, 7.4% of the patients were hospitalised (with higher rates in LC5), and 18% had persistent symptoms (with higher rates in LC5 and LC6). At 6 months, 6.4% of the patients had persistent symptoms, with no differences between LCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings might help GPs to identify patients at risk of persistent COVID-19 symptoms and hospital admission and then set up procedures for closer monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080393","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:20:19Z","timestamp":1717708819000},"page":"e080393","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 profiles in general practice: a latent class analysis"],"prefix":"10.1136","volume":"14","author":[{"given":"Emilie","family":"Ferrat","sequence":"first","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB, CepiA Team, Creteil, France"},{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"},{"name":"Maison de Sante Pluriprofessionnelle Universitaire (MSPU) Saint-Maur-Des-Fosses, MSPU, Saint-Maur-Des-Fosses, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-7837","authenticated-orcid":false,"given":"William","family":"Mirat","sequence":"additional","affiliation":[{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"},{"name":"Maison de Sante Pluriprofessionnelle Universitaire (MSPU) Torcy, MSPU, Torcy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Boutin","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB, CepiA Team, Creteil, France"},{"name":"AP-HP, Hopital Henri-Mondor, Clinical Research Unit (URC Mondor), AP-HP, Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Maroto","sequence":"additional","affiliation":[{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Brossier","sequence":"additional","affiliation":[{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"},{"name":"Maison de Sante Pluriprofessionnelle Universitaire (MSPU) Fontainebleau, MSPU, Fontainebleau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Denis","family":"Hoonakker","sequence":"additional","affiliation":[{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"},{"name":"Maison de Sante Pluriprofessionnelle Universitaire (MSPU) Nemours, MSPU, Nemours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB, CepiA Team, Creteil, France"},{"name":"AP-HP, Hopital Henri-Mondor, Clinical Research Unit (URC Mondor), AP-HP, Creteil, France"},{"name":"APHP, Hopital Henri-Mondor, Public Health Department, AP-HP, Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9990-7398","authenticated-orcid":false,"given":"Tan-Trung","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of General Practice, Univ Paris Est Creteil, Creteil, France"},{"name":"Maison de Sante Pluriprofessionnelle Universitaire (MSPU) Fontainebleau, MSPU, Fontainebleau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Bastuji-Garin","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB, CepiA Team, Creteil, France"},{"name":"APHP, Hopital Henri-Mondor, Public Health Department, AP-HP, Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"2025121508584839000_14.6.e080393.1","unstructured":"Coronavirus: chiffres cl\u00e9s et \u00e9volution de la COVID-19 en France et dans le Monde, 2023. 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