{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:43:38Z","timestamp":1765233818589,"version":"3.37.3"},"reference-count":28,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873635","81901401","82001223","82172685"],"award-info":[{"award-number":["81873635","81901401","82001223","82172685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiopulmonary complications and cognitive impairment following craniotomy have a significantly impact on the general health of individuals with brain tumours. Observational research indicates that engaging in walking is linked to better prognosis in patient after surgery. This trial aims to explore whether walking exercise prior to craniotomy in brain tumour patients can reduce the incidence of cardiopulmonary complications and preserve patients\u2019 cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>In this randomised controlled trial, 160 participants with supratentorial brain tumours aged 18\u201365 years, with a preoperative waiting time of more than 3\u20134 weeks and without conditions that would interfere with the trial such as cognitive impairment, will be randomly assigned in a ratio of 1:1 to either receive traditional treatment or additional combined with a period of 3\u20134\u2009weeks of walking exercise of 10\u2009000\u201315 000 steps per day. Wearable pedometer devices will be used to record step counts. The researchers will evaluate participants at enrolment, baseline, 14 days preoperatively, 3\u2009days prior to surgery and 1\u2009week after surgery or discharge (select which occurs first). The primary outcomes include the incidence of postoperative cardiopulmonary complications and changes in cognitive function (gauged by the Montreal Cognitive Assessment test). Secondary outcomes include the average length of hospital stay, postoperative pain, participant contentment, healthcare-associated costs and incidence of other postoperative surgery-related complications. We anticipate that short-term preoperative walking exercises will reduce the incidence of surgery-related complications in the short term after craniotomy, protect patients\u2019 cognitive function, aid patients\u2019 postoperative recovery and reduce the financial cost of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The study protocol has been approved by Ethics Committee of Xiangya Hospital of Central South University (approval number: 202305117). The findings of the research will be shared via publications that have been reviewed by experts in the field and through presentations at conferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"isrctn\" xlink:href=\"NCT05930288\">NCT05930288<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080787","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:40:17Z","timestamp":1718383217000},"page":"e080787","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative walking exercise to improve prognosis in patients with supratentorial brain tumours after craniotomy: protocol for a randomised controlled trial"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"isrctn05930288","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-0864","authenticated-orcid":false,"given":"Chunrun","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangkun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-7259","authenticated-orcid":false,"given":"Zhixiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024061409004874000_14.5.e080787.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30468-X"},{"key":"2024061409004874000_14.5.e080787.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21693"},{"key":"2024061409004874000_14.5.e080787.3","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200210000-00001"},{"key":"2024061409004874000_14.5.e080787.4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/00000658-199412000-00005","article-title":"The effect of length of stay on complications","volume":"220","author":"Moore","year":"1994","journal-title":"Ann Surg"},{"key":"2024061409004874000_14.5.e080787.5","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200501000-00005"},{"key":"2024061409004874000_14.5.e080787.6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1001\/jamainternmed.2022.4000","article-title":"Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality","volume":"182","author":"Del Pozo Cruz","year":"2022","journal-title":"JAMA Intern Med"},{"key":"2024061409004874000_14.5.e080787.7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jamasurg.2018.1645","article-title":"Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial","volume":"153","author":"Minnella","year":"2018","journal-title":"JAMA Surg"},{"key":"2024061409004874000_14.5.e080787.8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jtho.2016.09.125","article-title":"Short-term preoperative high-intensity interval training in patients awaiting lung cancer surgery: a randomized controlled trial","volume":"12","author":"Licker","year":"2017","journal-title":"J Thorac Oncol"},{"key":"2024061409004874000_14.5.e080787.9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/gerona\/glac123","article-title":"Walking for cognitive health: previous parity moderates the relationship between self-reported walking and cognition","volume":"78","author":"Barha","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2024061409004874000_14.5.e080787.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00078014"},{"key":"2024061409004874000_14.5.e080787.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2014.11.001"},{"key":"2024061409004874000_14.5.e080787.12","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.rmed.2009.03.015","article-title":"Natriuretic peptides for the prediction of severely impaired peak Vo2 in patients with lung disease","volume":"103","author":"Maeder","year":"2009","journal-title":"Respir Med"},{"key":"2024061409004874000_14.5.e080787.13","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12329"},{"key":"2024061409004874000_14.5.e080787.14","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-008-8031-4"},{"key":"2024061409004874000_14.5.e080787.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.018"},{"key":"2024061409004874000_14.5.e080787.16","unstructured":"Doyle DJ , Hendrix JM , Garmon EH . American Society of Anesthesiologists Classification 2023."},{"key":"2024061409004874000_14.5.e080787.17","doi-asserted-by":"publisher","DOI":"10.1590\/s2317-17822013000200017"},{"key":"2024061409004874000_14.5.e080787.18","first-page":"338","article-title":"Revision of the physical activity readiness questionnaire (PAR-Q)","volume":"17","author":"Thomas","year":"1992","journal-title":"Can J Sport Sci"},{"key":"2024061409004874000_14.5.e080787.19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1164\/rccm.2011P1","article-title":"Cardiopulmonary exercise testing (CPET)","volume":"201","author":"DeCato","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2024061409004874000_14.5.e080787.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"2024061409004874000_14.5.e080787.21","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.eururo.2017.06.037","article-title":"Recreational physical activity in relation to prostate cancer-specific mortality among men with nonmetastatic prostate cancer","volume":"72","author":"Wang","year":"2017","journal-title":"Eur Urol"},{"key":"2024061409004874000_14.5.e080787.22","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-105669"},{"key":"2024061409004874000_14.5.e080787.23","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0b013e31829a68cf"},{"key":"2024061409004874000_14.5.e080787.24","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"2024061409004874000_14.5.e080787.25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cct.2005.09.002","article-title":"Sequential balancing: a simple method for treatment allocation in clinical trials","volume":"26","author":"Borm","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"2024061409004874000_14.5.e080787.26","doi-asserted-by":"crossref","DOI":"10.2196\/18694","article-title":"Reliability and validity of commercially available wearable devices for measuring steps, energy expenditure, and heart rate: systematic review","volume":"8","author":"Fuller","year":"2020","journal-title":"JMIR Mhealth Uhealth"},{"key":"2024061409004874000_14.5.e080787.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-015-1236-x"},{"key":"2024061409004874000_14.5.e080787.28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-3-642-04231-7_16","article-title":"Physical activity motivation and cancer survivorship","volume":"186","author":"Pinto","year":"2011","journal-title":"Recent Results Cancer Res"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-080787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:40:31Z","timestamp":1718383231000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-080787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,15]]},"published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1136\/bmjopen-2023-080787"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-080787","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}