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These complications lead to increased immediate and long-term healthcare costs as well as reduced health and well-being in women and infants. This protocol presents the health economic evaluation to investigate the cost-effectiveness of Bump2Baby and Me (B2B&amp;Me), which is a health coaching intervention delivered via smartphone to women at risk of gestational diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>Using data from the B2B&amp;Me randomised controlled trial, this economic evaluation compares costs and health effects between the intervention and control group as an incremental cost-effectiveness ratio. Direct healthcare costs, costs of pharmaceuticals and intervention costs will be included in the analysis, body weight and quality-adjusted life-years for the mother will serve as the effect outcomes. To investigate the long-term cost-effectiveness of the trial, a Markov model will be employed. Deterministic and probabilistic sensitivity analysis will be employed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The National Maternity Hospital Human Research and Ethics Committee was the primary approval site (EC18.2020) with approvals from University College Dublin HREC-Sciences (LS-E-20-150-OReilly), Junta de Andalucia CEIM\/CEI Provincial de Granada (2087-M1-22), Monash Health HREC (RES-20-0000-892A) and National Health Service Health Research Authority and Health and Care Research Wales (HCRW) (21\/WA\/0022). The results from the analysis will be disseminated in scientific papers, through conference presentations and through different channels for communication within the project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>ACTRN12620001240932.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080823","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T02:56:40Z","timestamp":1716346600000},"page":"e080823","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for cost-effectiveness analysis of a randomised trial of mHealth coaching (Bump2Baby and Me) compared with usual care for healthy gestational weight gain and postnatal outcomes in at-risk women and their offspring in the UK, Australia, Ireland and Spain"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-2215","authenticated-orcid":false,"given":"Laura Pirhonen","family":"N\u00f8rmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionnuala","family":"McAuliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle Terkildsen","family":"Maindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharleen","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-6547","authenticated-orcid":false,"given":"Anna","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Burden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Vrangb\u00e6k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Callander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"2024052119552108000_14.5.e080823.1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajog.2014.08.021","article-title":"The future of obstetrics\/Gynecology in 2020: a clearer vision: finding true North and the forces of change","volume":"211","author":"Lagrew","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2024052119552108000_14.5.e080823.2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/GRF.0000000000000099","article-title":"Changes in obstetrics and gynecologic care Healthcare triple aims: moving women\u2019s Healthcare from volume to value","volume":"58","author":"Levy","year":"2015","journal-title":"Clin Obstet Gynecol"},{"key":"2024052119552108000_14.5.e080823.3","doi-asserted-by":"crossref","DOI":"10.1097\/AOG.0000000000003351","article-title":"In pursuit of value-based maternity care","volume":"134","author":"Saade","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2024052119552108000_14.5.e080823.4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ajog.2016.12.033","article-title":"Achieving higher-value Obstetrical care","volume":"216","author":"Woo","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2024052119552108000_14.5.e080823.5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202183","article-title":"Estimated global overweight and obesity burden in pregnant women based on panel data model","volume":"13","author":"Chen","year":"2018","journal-title":"PLoS ONE"},{"key":"2024052119552108000_14.5.e080823.6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bpobgyn.2020.06.006","article-title":"The impact of advanced maternal age on pregnancy outcome","volume":"70","author":"Attali","year":"2021","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"key":"2024052119552108000_14.5.e080823.7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.868094","article-title":"Prevalence and trends in gestational diabetes mellitus among women in the United States, 2006\u20132017: A population-based study","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"unstructured":"Federation; ID . 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