{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:30:47Z","timestamp":1765816247298,"version":"3.48.0"},"reference-count":86,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,12,12]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypothalamic hamartomas (HHs) are deep-seated congenital lesions that typically lead to pharmacoresistant epilepsy and a catastrophic encephalopathic syndrome characterised by severe neuropsychological impairment and decline in quality of life. A variety of surgical approaches and technologies are available for the treatment of HH-related pharmacoresistant epilepsy. There remains, however, a paucity of literature directly comparing their relative efficacy and safety. This protocol aims to facilitate a systematic review and meta-analysis that will characterise and compare the probability of seizure freedom and relevant postoperative complications across different surgical techniques performed for the treatment of HH-related pharmacoresistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This protocol was developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Individual Participant Data guidelines. Three major databases, PubMed, Embase and Scopus, will be systematically searched from database inception and without language restrictions for relevant articles using our predefined search strategy. Title\u2013abstract and full text screening using inclusion and exclusion criteria created a priori will be performed by two independent reviewers to identify eligible articles. Conflicts will be resolved via discussion with a third team member. Following data extraction of both study-level and individual patient data (IPD), a study-level and IPD meta-analysis will be performed. Study-level analysis will focus on assessing the degree of heterogeneity in the data and quantifying overall seizure outcomes for each surgical technique. The IPD analysis will use multivariable regression to determine perioperative predictors of seizure freedom and complications that can guide patient and technique selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This work will not require ethics approval as it will be solely based on previously published and available data. The results of this review will be shared via conference presentation and submission to peer-reviewed neurosurgical journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration<\/jats:title>\n                    <jats:p>CRD42022378876.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-080870","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T21:11:25Z","timestamp":1707772285000},"page":"e080870","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes following surgical interventions for hypothalamic hamartomas: protocol for a systematic review and individual patient data meta-analysis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-9298","authenticated-orcid":false,"given":"Keshav","family":"Goel","sequence":"first","affiliation":[{"name":"University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farbod","family":"Niazi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Shu","family":"Chen","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristides","family":"Hadjinicolaou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sainte-Justine University Hospital Center, Montreal, Quebec, Canada"},{"name":"Department of Neuroscience, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Keezer","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Imagerie Optique en Neurod\u00e9veloppement (LIONlab), Saint Justine University Hospital Research Centre, Montreal, Quebec, Canada"},{"name":"Department of Psychology, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aria","family":"Fallah","sequence":"additional","affiliation":[{"name":"University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G","family":"Weil","sequence":"additional","affiliation":[{"name":"Brain and Development Research Axis, Saint Justine University Hospital Research Centre, Montreal, Quebec, Canada"},{"name":"Department of Surgery, Division of Neurosurgery, Sainte-Justine University Hospital Center, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"2025121508273785000_14.2.e080870.1","first-page":"450","article-title":"MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases","volume":"25","author":"Freeman","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025121508273785000_14.2.e080870.2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/nen.0b013e3180302090","article-title":"The histopathology of hypothalamic hamartomas: study of 57 cases","volume":"66","author":"Coons","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025121508273785000_14.2.e080870.3","doi-asserted-by":"crossref","DOI":"10.3171\/2013.3.FOCUS1355","article-title":"Hypothalamic hamartomas. 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