{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:33:27Z","timestamp":1765737207130,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Roche Pharma GmbH","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,2,29]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Timely diagnosis of mild cognitive impairment (MCI) in Alzheimer\u2019s disease is crucial for early interventions, but its implementation is often challenging due to the complexity and time burden of required cognitive assessments. To address these challenges, the usability of new unsupervised digital remote assessment tools needs to be validated in a care context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This multicentric healthcare research evaluation survey, re.cogni.ze, aims to evaluate physician satisfaction with a remote digital assessment solution (neotivCare) in primary and specialised routine care in Germany. Over a period of 22 months, physicians in different regions of Germany will recommend the application (app) to approximately 1000 patients for a 12-week self-assessment of cognition. The primary endpoint is the evaluation of physicians\u2019 and patients\u2019 overall satisfaction with neotivCare and with neuropsychological questionnaires\/standard procedures using a Likert scale, while secondary endpoints include user-friendliness, qualitative assessment of acceptance and potential improvements on medical routine services. The study also aims to evaluate the proportion of physicians or patients attributing added value to neotivCare compared with standard paper\u2013pencil tests. The study results will provide insights into the feasibility, efficiency and acceptance of new digital tools for MCI diagnosis in routine care. The re.cogni.ze survey will thus provide proof-of-concept information for the implementation of remote digital cognitive assessment apps for MCI into medical routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study was approved by the ethics committee of the State Medical Association (Landes\u00e4rztekammer) Baden-W\u00fcrttemberg, (F-2021-161) as the leading committee and nine ethics committees local to the participating healthcare professionals (Lower Saxony, North Rhine, Westphalia-Lippe, Hesse, Bremen, Berlin, University of G\u00f6ttingen, Charite, University of Rostock). The results can be shared (upon reasonable quest) to improve routine clinical processes and holistic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-081159","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T01:50:58Z","timestamp":1710294658000},"page":"e081159","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Protocol: Prospective evaluation of feasibility, added value and satisfaction of remote digital self-assessment for mild cognitive impairment in routine care with the neotivCare app"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-5388","authenticated-orcid":false,"given":"Emrah","family":"Duzel","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Magdeburg, Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sch\u00f6ttler","sequence":"additional","affiliation":[{"name":"Roche Pharma AG, Grenzach-Wyhlen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Sommer","sequence":"additional","affiliation":[{"name":"Roche Pharma AG, Grenzach-Wyhlen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Griebe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"2025121410322376000_14.3.e081159.1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279336.36610.f7"},{"key":"2025121410322376000_14.3.e081159.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"2025121410322376000_14.3.e081159.3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/alz.12674","article-title":"Subjective cognitive decline and stage 2 of alzheimer disease in patients from memory centers","volume":"19","author":"Jessen","year":"2023","journal-title":"Alzheimers Dement"},{"key":"2025121410322376000_14.3.e081159.4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00103-020-03120-z","article-title":"Pharmacological prevention of cognitive decline and dementia","volume":"63","author":"Jessen","year":"2020","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"2025121410322376000_14.3.e081159.5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.14283\/jpad.2020.9","article-title":"Targeting lifestyle behavior to improve brain health: user-experiences of an online program for individuals with subjective cognitive decline","volume":"7","author":"Wesselman","year":"2020","journal-title":"J Prev Alzheimers Dis"},{"key":"2025121410322376000_14.3.e081159.6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002609","article-title":"Testing the right target and right drug at the right stage","volume":"3","author":"Sperling","year":"2011","journal-title":"Sci Transl Med"},{"key":"2025121410322376000_14.3.e081159.7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3233\/JAD-191191","article-title":"Brief cognitive tests used in primary care cannot accurately differentiate mild cognitive impairment from subjective cognitive decline","volume":"75","author":"Petrazzuoli","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"2025121410322376000_14.3.e081159.8","doi-asserted-by":"crossref","unstructured":"Costa A , Bak T , Caffarra P , et al . 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Cognitive impairment in long Covid: phenotyping and rehabilitation (CICERO). n.d. 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