{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:40:14Z","timestamp":1769182814120,"version":"3.49.0"},"reference-count":29,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,2,14]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Cerebral aneurysms (CAs) are linked to variations in the cerebral basal arterial network (CBAN). This study aimed to find the optimal age for screening to detect brain arterial variations and predict aneurysms before rupture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>An observational, quantitative and retrospective research.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The study analysed 1127\u2009cases of CAs published from 1761 to 1938. Additionally, CT angiography images of 173-patients at the Royal Adelaide Hospital (RAH), South Australia between 2011 and 2019 were examined for the presence and the location of aneurysms in CBAN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>The data were collected from patients at RAH and 407 published sources, including males and females across the entire age range, up to 100 years old.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome measures and results<\/jats:title>\n                  <jats:p>Data, CAs cases, from 1761 to 1938 included (526 males, 573\u2009females and 28 unknown sexes). The age of these patients varied from 18 months to 89\u2009years (mean age=42, SD=18). Approximately 11.5% of the CAs occurred in patients aged &lt;20\u2009years. Among the 1078 aneurysms whose location was reported, 76% were located in the internal carotid (IC), middle cerebral (MC) and anterior communicating artery complex (AcomAC) regions, while the remaining 24% were in the vertebrobasilar region. Among 173\u2009patients from RAH aged between 18 and 100 years (male=83\u2009and female=90, mean age=60, SD=16), 94% of the CAs were found in the IC, MC and AcomAC regions. The pattern of aneurysm occurrence, as indicated by values at the 25th, 50th and 75th percentiles, along with the minimum and maximum patient ages, has remained consistent from 1761 to 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The distribution pattern of CAs in relation to sex, age and locations in the CBAN, remained steady over the last 260\u2009years resulting in risk of strokes early in life. Therefore, early screening for CBAN segment variations is advised for stroke prevention if possible.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-081290","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T03:31:04Z","timestamp":1709091064000},"page":"e081290","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Trend of cerebral aneurysms over the past two centuries: need for early screening"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-6352","authenticated-orcid":false,"given":"Arjun","family":"Burlakoti","sequence":"first","affiliation":[{"name":"Human Anatomy, University of South Australia, Adelaide, South Australia, Australia"},{"name":"School of Biomedicine, Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaliya","family":"Kumaratilake","sequence":"additional","affiliation":[{"name":"School of Biomedicine, Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Taylor","sequence":"additional","affiliation":[{"name":"South Australia Medical Imaging, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-2286","authenticated-orcid":false,"given":"Maciej","family":"Henneberg","sequence":"additional","affiliation":[{"name":"School of Biomedicine, Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Institute of Evolutionary Medicine, The University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"2025101810224666000_14.2.e081290.1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-051028","article-title":"Relationship between cerebral aneurysms and variations in cerebral basal arterial network: a morphometric cross-sectional study in computed tomography angiograms from a neurointerventional unit","volume":"11","author":"Burlakoti","year":"2021","journal-title":"BMJ Open"},{"key":"2025101810224666000_14.2.e081290.2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.2.144"},{"key":"2025101810224666000_14.2.e081290.3","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.PEDS11455"},{"key":"2025101810224666000_14.2.e081290.4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00508-011-1598-z","article-title":"Aneurysmatic subarachnoidal haemorrhage: incidence and location of small ruptured cerebral aneurysms \u2013 a retrospective population-based study","volume":"123","author":"Roessler","year":"2011","journal-title":"Wien Klin Wochenschr"},{"key":"2025101810224666000_14.2.e081290.5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000120073","article-title":"Intracranial aneurysms in the pediatric age-group","volume":"9","author":"Storrs","year":"1982","journal-title":"Pediatr Neurosurg"},{"key":"2025101810224666000_14.2.e081290.6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.5.0733"},{"key":"2025101810224666000_14.2.e081290.7","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.42.105"},{"key":"2025101810224666000_14.2.e081290.8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.wneu.2016.04.044","article-title":"Size and location of ruptured intracranial aneurysms: a 5-year clinical survey","volume":"91","author":"Froelich","year":"2016","journal-title":"World Neurosurg"},{"key":"2025101810224666000_14.2.e081290.9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526905"},{"key":"2025101810224666000_14.2.e081290.10","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2009.45.1.11"},{"key":"2025101810224666000_14.2.e081290.11","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.JNS161085"},{"key":"2025101810224666000_14.2.e081290.12","doi-asserted-by":"publisher","DOI":"10.3171\/2017.9.JNS171191"},{"key":"2025101810224666000_14.2.e081290.13","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.518761"},{"key":"2025101810224666000_14.2.e081290.14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archneurpsyc.1939.02270200118011","article-title":"Intracranial aneurysms","volume":"42","author":"McDonald","year":"1939","journal-title":"Arch NeurPsych"},{"key":"2025101810224666000_14.2.e081290.15","unstructured":"Moore S , Simon JL . 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