{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:53:37Z","timestamp":1785236017255,"version":"3.55.0"},"reference-count":31,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University Institute of Internal Medicine","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Basel Region Childhood Cancer Foundation","award":["#2020-F009"],"award-info":[{"award-number":["#2020-F009"]}]},{"name":"Bern Foundation for children and adolescents with cancer","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,6,21]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In our study, we aimed to characterise adult childhood cancer survivors (ACCS), assess their health issues, gauge health-related quality of life (HRQOL) and evaluate visit satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study using data from clinical visits and questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Interdisciplinary follow-up programme for ACCS based on the long-term follow-up (LTFU) guidelines of the Children\u2019s Oncology Group and overseen by internists in two Swiss hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>ACCS attending our LTFU clinics between April 2017 and January 2022 were eligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>We documented medical history, current health status and assessed HRQOL using Short Form-36 V.2, comparing it with Swiss general population (SGP) norms (T mean=50, SD=10; age stratified). 3 months post visit, a feedback questionnaire was distributed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Among 102 ACCS (mean age: 32 years (range: 18\u201362 years), 68% women), 43 had no prior follow-up (36 ACCS&gt;28 years, 7 ACCS\u226428 years). A notable 94% had health issues, affecting an average of 6.1 (SD=3.3) organ systems. HRQOL was lower in ACCS&gt;28 years than the SGP&gt;28 years (physical: 44.8 (SD=11.65) vs 49.3 (SD=10.29), p=0.016; mental: 44.4 (SD=13.78) vs 50.53 (SD=9.92), p=0.004). Older ACCS (&gt;28 years) reported inferior physical (44.8 vs 50.1 (SD=9.30), p=0.017) and mental HRQOL (44.4 vs 50.3 (SD=7.20), p=0.009) than younger ACCS. The majority of respondents reported high levels of satisfaction with the consultation, exceeding 90%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACCS attending LTFU clinics face diverse health issues impacting multiple organ systems and exhibit lower HRQOL compared with the SGP. Thus, internist-led LTFU clinics are crucial for optimising follow-up care.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-081823","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T09:00:54Z","timestamp":1720688454000},"page":"e081823","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and feedback of adult survivors of childhood cancer seen in Swiss comprehensive follow-up clinics led by general internists: a prospective cohort study"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-8097","authenticated-orcid":false,"given":"Eva Maria Eugenia","family":"Tinner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oezcan","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boesing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-3333","authenticated-orcid":false,"given":"Katharina","family":"Roser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-0928","authenticated-orcid":false,"given":"Gisela","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Elisabeth","family":"Minder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"Bayha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Affolter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-9632","authenticated-orcid":false,"given":"Christine","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Meienberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-0928","authenticated-orcid":false,"given":"Claudia","family":"Kuehni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4022-4917","authenticated-orcid":false,"given":"Jochen","family":"R\u00f6ssler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-0198","authenticated-orcid":false,"given":"Maria M","family":"Wertli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-0675","authenticated-orcid":false,"given":"J\u00f6rg D","family":"Leuppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"2024082721253690000_14.7.e081823.1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.critrevonc.2017.04.007","article-title":"The impact of long-term follow-up care for childhood cancer survivors: a systematic review","volume":"114","author":"Signorelli","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"2024082721253690000_14.7.e081823.2","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0140-6736(17)31610-0","article-title":"The cumulative burden of surviving childhood cancer: an initial report from the St Jude lifetime cohort study (SJLIFE)","volume":"390","author":"Bhakta","year":"2017","journal-title":"Lancet"},{"key":"2024082721253690000_14.7.e081823.3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.55395","article-title":"Association of modifiable health conditions and social determinants of health with late mortality in survivors of childhood cancer","volume":"6","author":"Ehrhardt","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2024082721253690000_14.7.e081823.4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30080"},{"key":"2024082721253690000_14.7.e081823.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.09.017"},{"key":"2024082721253690000_14.7.e081823.6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr142"},{"key":"2024082721253690000_14.7.e081823.7","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0288-4"},{"key":"2024082721253690000_14.7.e081823.8","unstructured":"Schweizerischer Krebsbericht 2021 - stand und Entwicklungen. 2021. 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