{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:00:43Z","timestamp":1765080043770,"version":"3.46.0"},"reference-count":41,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71774034 and 71373182"],"award-info":[{"award-number":["71774034 and 71373182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,7,31]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the rational prescription of medicines by village clinics following China\u2019s implementation of the New Healthcare System Reform (NHCSR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Village clinics in a province in eastern China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>\n                      Our evaluation was based on the core drug use indicators reported in the study \u2018\n                      <jats:italic>How to Investigate Drug Use in Health Facilities: Selected Drug Use Indicators<\/jats:italic>\n                      \u2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The level of rational use of medicines (RUMs) in village clinics improved in 2018 compared with 2009; the average number of drugs per prescription decreased from 3.66 to 2.77, the percentage of prescriptions including antibiotics decreased from 65.40% to 46.00%, and the percentage of prescriptions including injections decreased from 55.75% to 37.48% (all p&lt;0.01), whereas the percentage of drugs prescribed from the list of essential medicines increased from 66.50% to 80.34%, and the percentage of drugs prescribed by generic names increased from 61.29% to 70.65% (all p&lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The level of RUMs improved after the implementation of the NHCSR, however, it was found that there was still a gap between the level of RUMs in 2018 and the international reference value. Financial investments, electronic prescription systems, improved supervision and regular training are essential actions that must be implemented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-081908","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T23:06:06Z","timestamp":1730588766000},"page":"e081908","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of rational prescription of medicines by village clinics: a repeated cross-sectional study of a province in eastern China"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3198-715X","authenticated-orcid":false,"given":"Chunyan","family":"Song","sequence":"first","affiliation":[{"name":"School of Public Health, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-6676","authenticated-orcid":false,"given":"Zhongming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Feng","sequence":"additional","affiliation":[{"name":"China National Health Development Research Center, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Hao","sequence":"additional","affiliation":[{"name":"China National Health Development Research Center, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"2025120618305369000_14.11.e081908.1","doi-asserted-by":"crossref","unstructured":"Aaserud M , Austvoll-Dahlgren A , Sturm H , et al . 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Available: https:\/\/www.who.int\/activities\/promoting-rational-use-of-medicines [Accessed 23 Apr 2023]."},{"key":"2025120618305369000_14.11.e081908.3","first-page":"419","article-title":"Rationality of medicine use in rural areas of Gansu province","volume":"33","author":"Li","year":"2017","journal-title":"Chin J Public Health"},{"key":"2025120618305369000_14.11.e081908.4","first-page":"19","article-title":"Regional differences of the rational use of drugs in rural healthcare facilities in western China","volume":"9","author":"Luo","year":"2016","journal-title":"Chin J Health Policy"},{"key":"2025120618305369000_14.11.e081908.5","first-page":"3297","article-title":"Impact of essential medicine system on antibiotics use: A Meta analysis","volume":"15","author":"Chen","year":"2012","journal-title":"Chin Gen Pract"},{"key":"2025120618305369000_14.11.e081908.6","unstructured":"Chen ZM , Yin WQ , Song J , et al . Study on Vulnerability of Village Clinic Doctors in Shandong Province in the Context of the New Medical Reform. Beijing: China Social Sciences Press, 2018:173."},{"key":"2025120618305369000_14.11.e081908.7","first-page":"2401","article-title":"Rational Use of Antibiotics to Inhibit the Extension of Bacterial Resistance","volume":"22","author":"Ma","year":"2011","journal-title":"Chin Pharm"},{"key":"2025120618305369000_14.11.e081908.8","first-page":"1","article-title":"Study on the rational drug use in primary health care institutions in Shanxi Province","volume":"25","author":"Cai","year":"2016","journal-title":"Chin Pharm"},{"key":"2025120618305369000_14.11.e081908.9","first-page":"274","article-title":"Investigation and analysis of drug use in some village clinics in Xuzhou City","volume":"22","author":"Yang","year":"2014","journal-title":"Pharm Clin Res"},{"key":"2025120618305369000_14.11.e081908.10","unstructured":"National Health Commission of the People\u2019s Republic of China . China Health Statistics Yearbook. Beijing, China: Peking Union Medical College Press, 2022:181."},{"key":"2025120618305369000_14.11.e081908.11","unstructured":"World Health Organization . How to investigate drug use in health facilities: selected drug use indicators. 1993. Available: https:\/\/www.bing.com\/ck\/a?!&&p=3529120ce0e321c6JmltdHM9MTcxMTU4NDAwMCZpZ3VpZD0zYWIwZWI4ZC1jZWNjLTZkZmUtM2U2NC1mODA1Y2ZkMTZjMDcmaW5zaWQ9NTE4Mw&ptn=3&ver=2&hsh=3&fclid=3ab0eb8d-cecc-6dfe-3e64-f805cfd16c07&psq=World+Health+Organization.+How+to+investigate+drug+use+in+health+facilities%3a+Selected+drug+use+indicators.+Geneva%3aWorld+Health+Organization%3b+1993.&u=a1aHR0cHM6Ly93d3cud2hvLmludC9wdWJsaWNhdGlvbnMtZGV0YWlsLXJlZGlyZWN0L3doby1kYXAtOTMuMQ&ntb=1 [Accessed 28 Mar 2024]."},{"key":"2025120618305369000_14.11.e081908.12","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-016-3428-8","article-title":"Prescribing indicators at primary health care centers within the WHO African region: a systematic analysis (1995-2015)","volume":"16","author":"Ofori-Asenso","year":"2016","journal-title":"BMC Public Health"},{"key":"2025120618305369000_14.11.e081908.13","article-title":"Irrational Use of Medicines-A Summary of Key Concepts","volume":"4","author":"Ofori-Asenso","year":"2016","journal-title":"Pharmacy (Basel)"},{"key":"2025120618305369000_14.11.e081908.14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12913-017-2097-3","article-title":"Evaluation of rational drug use based on World Health Organization core drug use indicators in selected public hospitals of eastern Ethiopia: a cross sectional study","volume":"17","author":"Sisay","year":"2017","journal-title":"BMC Health Serv Res"},{"key":"2025120618305369000_14.11.e081908.15","unstructured":"Dumoulin J , Kaddar M . Guide to drug financing mechanisms. Geneva,Switzerland World Health Organization; 1998.45."},{"key":"2025120618305369000_14.11.e081908.16","unstructured":"Wang ZS . Investigation on the Change Law of Basic Drug Use in Community Medical Institutions before and after the Implementation of the National Essential Drug System. Guangzhou, China: Southern Medical University, 2017:1."},{"key":"2025120618305369000_14.11.e081908.17","unstructured":"Chen ZM . The Study on Situation of Outpatient Medication in Township Hospitals of Shandong Province under the Background of Essential Medicine System-to Take the Some City as Example. Weifang, China: Weifang Medical University, 2014:53\u20134."},{"key":"2025120618305369000_14.11.e081908.18","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-014-0507-3","article-title":"The impact of China\u2019s national essential medicine system on improving rational drug use in primary health care facilities: an empirical study in four provinces","volume":"14","author":"Song","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"2025120618305369000_14.11.e081908.19","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-14-268","article-title":"Evaluation of the effects of comprehensive reform on primary healthcare institutions in Anhui Province","volume":"14","author":"Liu","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"2025120618305369000_14.11.e081908.20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5246\/jcps.2019.01.006","article-title":"The impacts of national essential medicine policies on the rational use of medicines in China: A cross-sectional study in primary health care institution","volume":"28","author":"Lu","year":"2019","journal-title":"J Chin Pharm Sci"},{"key":"2025120618305369000_14.11.e081908.21","first-page":"3758","article-title":"Comprehensive Evaluation on Prescription Appropriateness Indicators of Village Doctors in 11 Counties of Shandong Province Before and After the Implementation of National Essential Medicine Policy","volume":"17","author":"Guan","year":"2014","journal-title":"Chin Gen Pract"},{"key":"2025120618305369000_14.11.e081908.22","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/2168479014527748","article-title":"Does the Essential Medicines Policy Succeed in China? 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Wuhan, China: Huazhong University of Science and Technology, 2009:10."},{"key":"2025120618305369000_14.11.e081908.24","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-10-211","article-title":"Availability and use of essential medicines in China: manufacturing, supply, and prescribing in Shandong and Gansu provinces","volume":"10","author":"Chen","year":"2010","journal-title":"BMC Health Serv Res"},{"key":"2025120618305369000_14.11.e081908.25","first-page":"2266","article-title":"Prescription charge in rural health service settings in Shandong Province under the national essential medicine system","volume":"19","author":"Chen","year":"2016","journal-title":"Chin Gen Pract"},{"key":"2025120618305369000_14.11.e081908.26","first-page":"2269","article-title":"Influencing factors for patients with chronic diseases being given priority to use essential medicines","volume":"18","author":"Hu","year":"2015","journal-title":"Chin Gen Pract"},{"key":"2025120618305369000_14.11.e081908.27","first-page":"75","article-title":"Influencing Analysis of the National Essential Medicines Policy on Rational Usage of Medicines in Primary Health Facilities","volume":"35","author":"Song","year":"2015","journal-title":"Chin Hosp Manag"},{"key":"2025120618305369000_14.11.e081908.28","first-page":"90","article-title":"Discussion on the influence of the national Essential medicines system on the rational use of drugs in primary medical institutions","volume":"15","author":"Zhu","year":"2018","journal-title":"China Health Ind"},{"key":"2025120618305369000_14.11.e081908.29","first-page":"835","article-title":"Use of antibiotics in village clinics before and after the implementation of essential medicine policy in Shandong Province","volume":"17","author":"Guan","year":"2014","journal-title":"Chin Gen Pract"},{"key":"2025120618305369000_14.11.e081908.30","first-page":"737","article-title":"Analysis of influence factors for rational drug use by rural doctors in the essential medicine system","volume":"31","author":"Zhao","year":"2015","journal-title":"Chin J Hosp Adm"},{"key":"2025120618305369000_14.11.e081908.31","first-page":"303","article-title":"Investigation and Analysis of the Effects of Essential Medicine System on Rational Drug Use in Primary Health Care Institutions of Anhui Province","volume":"25","author":"Wu","year":"2014","journal-title":"Chin Pharm"},{"key":"2025120618305369000_14.11.e081908.32","unstructured":"National Medical Products Administration . National adverse drug reaction monitoring annual report. 2021. Available: https:\/\/www.nmpa.gov.cn\/xxgk\/fgwj\/gzwj\/gzwjyp\/20220329161925106.html [Accessed 30 Apr 2023]."},{"key":"2025120618305369000_14.11.e081908.33","first-page":"182","article-title":"Comprehensive evaluation on the prescription behavior for outpatients in primary health care institutions of Yiyang","volume":"41","author":"Ren","year":"2016","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"2025120618305369000_14.11.e081908.34","first-page":"508","article-title":"Factors that Affected Antibiotic Prescribing in Rural Western China","volume":"30","author":"Dong","year":"2013","journal-title":"Chin J Health Stat"},{"key":"2025120618305369000_14.11.e081908.35","first-page":"20","article-title":"Medication analysis of prescriptions in village clinics of a city based on WHO \/INRUD rational drug use index system","volume":"30","author":"Meng","year":"2021","journal-title":"Pharm Admin"},{"key":"2025120618305369000_14.11.e081908.36","first-page":"343","article-title":"Evaluation of the implementation effect of the basic drug system in four provinces and cities from the perspective of rational drug use","volume":"29","author":"Yao","year":"2013","journal-title":"Chin J Hosp Adm"},{"key":"2025120618305369000_14.11.e081908.37","unstructured":"Yin WQ , Chen ZM , Wei Y . A Study on the Accessibility of Essential Drugs in Township Health Centers in Shandong Province. Beijing: China Social Sciences Press, 2018:2."},{"key":"2025120618305369000_14.11.e081908.38","first-page":"122","article-title":"A survey on the knowledge, belief and practice of rational use of antibiotics in outpatient patients","volume":"26","author":"Tang","year":"2015","journal-title":"Jiangsu J Prev Med"},{"key":"2025120618305369000_14.11.e081908.39","unstructured":"Lin TF , Hu M , Yang L , et al . The impact of national essential medicines systems on rational drug use in primary health care institutions in China: a systematic analysis. In: Chinese Pharmaceutical Association. 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