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Therefore, the University of Edinburgh and Sony Research have partnered to create the Speech for Intelligent cognition change tracking and DEtection of Alzheimer\u2019s Disease (SIDE-AD) study, which aims to develop digital speech-based biomarkers for use in neurodegenerative disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>SIDE-AD is an observational longitudinal study, collecting samples of spontaneous speech. Participants are recruited from existing cohort studies as well as from the National Health Service (NHS)memory clinics in Scotland. Using an online platform, participants record a voice sample talking about their brain health and rate their mood, anxiety and apathy. The speech biomarkers will be analysed longitudinally, and we will use machine learning and natural language processing technology to automate the assessment of the respondents\u2019 speech patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The SIDE-AD study has been approved by the NHS Research Ethics Committee (REC reference: 23\/WM\/0153, protocol number AC23046, IRAS Project ID 323311) and received NHS management approvals from Lothian, Fife and Forth Valley NHS boards. Our main ethical considerations pertain to the remote administration of the study, such as taking remote consent. To address this, we implemented a consent process, whereby the first step of the consent is done entirely remotely but a member of the research team contacts the participant over the phone to consent participants to the optional, most sensitive, elements of the study. Results will be presented at conferences, published in peer-reviewed journals and communicated to study participants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-082388","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:03:28Z","timestamp":1711634608000},"page":"e082388","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal observational cohort study: Speech for Intelligent cognition change tracking and DEtection of Alzheimer\u2019s Disease (SIDE-AD)"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-2505","authenticated-orcid":false,"given":"Stina","family":"Saunders","sequence":"first","affiliation":[{"name":"University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasih","family":"Haider","sequence":"additional","affiliation":[{"name":"Usher Institute, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Scottish Brain Sciences, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Muniz Terrera","sequence":"additional","affiliation":[{"name":"Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK"},{"name":"Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-7875","authenticated-orcid":false,"given":"Saturnino","family":"Luz","sequence":"additional","affiliation":[{"name":"Usher Institute of Population Health Sciences and Informatics, University of Edinburgh School of Molecular Genetic and Population Health Sciences, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"2025121409265678000_14.3.e082388.1","unstructured":"Gauthier S , Rosa-Neto P , Morais JA , et al . 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