{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:07:11Z","timestamp":1771031231970,"version":"3.50.1"},"reference-count":60,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Accelerating Higher Education Expansion and Development (AHEAD) Operation of the Ministry of Higher Education, Sri Lanka, funded by the World Bank","award":["DOR STEM HEMS [6026-LK\/8743-LK]"],"award-info":[{"award-number":["DOR STEM HEMS [6026-LK\/8743-LK]"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,9,26]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the productivity loss and cost due to maternal ill-health conditions and its associated factors throughout pregnancy in rural Sri Lanka.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A follow-up study of women registered in the Rajarata Pregnancy Cohort (RaPCo).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Anuradhapura district, Sri Lanka.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>1573 pregnant women who were followed up from pregnancy identification to termination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>The primary outcome measures of this study are productivity loss due to maternal ill-health conditions expressed by days\/month and productivity cost due to maternal ill-health conditions expressed in monetary terms (US$)\/month. Data were collected monthly, and all pregnant women were asked to report the leading cause of maternal ill-health condition and the associated loss due to absenteeism and presenteeism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the pregnancy follow-up, 3595 (81.5%) months had at least one episode of maternal ill-health condition. Of these, only 1729 (48.1%) episodes sought medical care. Assistance for lost routine work was reported in 1281 (35.6%) episodes. The absenteeism, presenteeism and gross and net productivity loss per month were 3.6, 4.5, 8.1 and 5.5\u2009days\/month, respectively. The corresponding productivity cost was US$15.26\/month. Nausea and vomiting (NVP) reported the highest prevalence (n=1599, 44.5%) until the second month of the third trimester, presenteeism (5.5\u2009days\/month) and gross productivity loss (9.5\u2009days\/month). Pregnant women with vaginal bleeding reported the highest absenteeism (6.2\u2009days\/month) and net productivity loss (6.8\u2009days\/month). Pregnant women diagnosed with anaemia reported the highest productivity cost (US$26.98\/month). Monthly household expenditure, poverty and receiving assistance were the associated factors of productivity loss (p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal ill-health conditions during pregnancy lead to productivity loss in rural Sri Lanka. NVP, vaginal bleeding and anaemia are the leading causes of productivity loss. Hence, controlling and preventing the leading causes are the recommended priorities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-082798","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:26:06Z","timestamp":1730287566000},"page":"e082798","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the productivity loss due to leading maternal ill-health conditions: a follow-up study of a prospective pregnancy cohort in rural Sri Lanka"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0721-598X","authenticated-orcid":false,"given":"Sajan Praveena","family":"Gunarathna","sequence":"first","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-6022","authenticated-orcid":false,"given":"Nuwan Darshana","family":"Wickramasinghe","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-6578","authenticated-orcid":false,"given":"Thilini Chanchala","family":"Agampodi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indika Ruwan","family":"Prasanna","sequence":"additional","affiliation":[{"name":"Department of Economics, Faculty of Social Sciences and Humanities, Rajarata University of Sri Lanka, Mihintale, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-1774","authenticated-orcid":false,"given":"Suneth Buddhika","family":"Agampodi","sequence":"additional","affiliation":[{"name":"Center for Public Health, Anuradhapura, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"2025121410250252000_14.10.e082798.1","unstructured":"World Health Organization . Global health estimates: leading causes of dalys. disease burden, 2000\u20132019: daly estimates, 2000\u20132019, global summary estimates. 2023. Available: https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\/global-health-estimates-leading-causes-of-dalys [Accessed 01 Feb 2023]."},{"key":"2025121410250252000_14.10.e082798.2","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-020-03216-z","article-title":"Measurement of maternal functioning during pregnancy and postpartum: findings from the cross-sectional WHO pilot study in Jamaica, Kenya, and Malawi","volume":"20","author":"Cresswell","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025121410250252000_14.10.e082798.3","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.4.327"},{"key":"2025121410250252000_14.10.e082798.4","first-page":"84","article-title":"Estimation of Out of Pocket Expenditure Under Janani Shishu Suraksha Karayakram (JSSK) in Rural Block of Chhattisgarh: A Community Based Cross-Sectional Study","volume":"8","author":"Chandrakar","year":"2017","journal-title":"Natl J Community Med"},{"key":"2025121410250252000_14.10.e082798.5","unstructured":"Chaikledkaew U . Cost assessment. Cost assessment of health intervention and technology assessment program. 2011."},{"key":"2025121410250252000_14.10.e082798.6","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1136\/bmj.320.7245.1335","article-title":"Cost-of-illness studies","volume":"320","author":"Byford","year":"2000","journal-title":"Br Med J"},{"key":"2025121410250252000_14.10.e082798.7","first-page":"202","article-title":"Household health costs: Direct, indirect and intangible","volume":"43","author":"Yousefi","year":"2014","journal-title":"Iran J Public Health"},{"key":"2025121410250252000_14.10.e082798.8","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2010.0014"},{"key":"2025121410250252000_14.10.e082798.9","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000126687.49652.44"},{"key":"2025121410250252000_14.10.e082798.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000100200.90573.df"},{"key":"2025121410250252000_14.10.e082798.11","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000099999.27348.78"},{"key":"2025121410250252000_14.10.e082798.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000052967.43131.51"},{"key":"2025121410250252000_14.10.e082798.13","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200103000-00009"},{"key":"2025121410250252000_14.10.e082798.14","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-11-417","article-title":"Health-related productivity losses increase when the health condition is co-morbid with psychological distress: findings from a large cross-sectional sample of working Australians","volume":"11","author":"Holden","year":"2011","journal-title":"BMC Public Health"},{"key":"2025121410250252000_14.10.e082798.15","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-012-1174-9"},{"key":"2025121410250252000_14.10.e082798.16","doi-asserted-by":"crossref","unstructured":"Suryakantha AH . Community Medicine with Recent Advances. 3rd edn. New Dilhi, India: Jaypee Brothers Medical Publishers, 2014:966.","DOI":"10.5005\/jp\/books\/12215"},{"key":"2025121410250252000_14.10.e082798.17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042333","article-title":"Productivity cost due to maternal ill health in Sri Lanka","volume":"7","author":"Agampodi","year":"2012","journal-title":"PLoS ONE"},{"key":"2025121410250252000_14.10.e082798.18","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-020-06027-2","article-title":"Out-of-pocket costs and time spent attending antenatal care services: a case study of pregnant women in selected rural communities in Zinder, Niger","volume":"21","author":"Ou\u00e9draogo","year":"2021","journal-title":"BMC Health Serv Res"},{"key":"2025121410250252000_14.10.e082798.19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1353\/hpu.2010.0248","article-title":"Personal Costs Associated With High-Risk Prenatal Care Attendance","volume":"9","author":"Stringer","year":"1998","journal-title":"hpu"},{"key":"2025121410250252000_14.10.e082798.20","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-018-3736-z","article-title":"Time and cost associated with utilization of services at mobile health clinics among pregnant women","volume":"18","author":"Neke","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"2025121410250252000_14.10.e082798.21","doi-asserted-by":"publisher","DOI":"10.2307\/3583147"},{"key":"2025121410250252000_14.10.e082798.22","unstructured":"World Bank Group . World bank country and lending groups-country classification. Data; 2021.1. Available: https:\/\/datahelpdesk.worldbank.org\/knowledgebase\/articles\/906519-world-bank-country-and-lending-groups [accessed 19 Nov 2021]"},{"key":"2025121410250252000_14.10.e082798.23","first-page":"82","article-title":"Universal health coverage and the health Sustainable Development Goal: achievements and challenges for Sri Lanka","volume":"5","author":"de Silva","year":"2016","journal-title":"WHO SEA J Public Health"},{"key":"2025121410250252000_14.10.e082798.24","first-page":"203","article-title":"Obstetric transition in the World Health Organization Multicountry Survey on Maternal and Newborn Health: Exploring pathways for maternal mortality reduction","volume":"37","author":"Cruz Chaves","year":"2015","journal-title":"Rev Panam Salud Publica\/Pan Am J Public Heal"},{"key":"2025121410250252000_14.10.e082798.25","unstructured":"Family Health Bureau-Ministry of Health . Maternal Care Package: A Guide to Field Health Care Workers. 1st edn. Colombo, 2011."},{"key":"2025121410250252000_14.10.e082798.26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4038\/sljm.v30i2.328","article-title":"Maternal and child health and nutrition (MCHN) policies and programs in Sri Lanka: a paradigm for public health in Asia","volume":"30","author":"Agampodi","year":"2021","journal-title":"SL J Med"},{"key":"2025121410250252000_14.10.e082798.27","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-022-01527-2"},{"key":"2025121410250252000_14.10.e082798.28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064214","article-title":"Minor ailments in pregnancy are not a minor concern for pregnant women: a morbidity assessment survey in rural Sri Lanka","volume":"8","author":"Agampodi","year":"2013","journal-title":"PLoS ONE"},{"key":"2025121410250252000_14.10.e082798.29","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzaa054_068","article-title":"Economic Status, Nutrition and Pregnancy Cost; A Vicious Cycle in Pregnancy","volume":"4","author":"Gunarathne","year":"2020","journal-title":"Curr Dev Nutr"},{"key":"2025121410250252000_14.10.e082798.30","doi-asserted-by":"crossref","unstructured":"Gunarathne SP , Wickramasinghe ND , Agampodi TC , et al . Out-of-pocket expenditure for antenatal care instills amidst free health care provision: evidence from a large pregnancy cohort in rural sri lanka. In Review [Preprint]. doi:10.21203\/rs.3.rs-1891492\/v1","DOI":"10.21203\/rs.3.rs-1891492\/v1"},{"key":"2025121410250252000_14.10.e082798.31","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzab046_051"},{"key":"2025121410250252000_14.10.e082798.32","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-021-07005-y","article-title":"How costly is the first prenatal clinic visit? Analysis of out-of-pocket expenditure in rural Sri Lanka - a country with free maternal health care","volume":"21","author":"Gunarathne","year":"2021","journal-title":"BMC Health Serv Res"},{"key":"2025121410250252000_14.10.e082798.33","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzab046_050"},{"key":"2025121410250252000_14.10.e082798.34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9745\/GHSP-D-22-00410","article-title":"Out-of-Pocket Expenditure for Antenatal Care Amid Free Health Care Provision: Evidence From a Large Pregnancy Cohort in Rural Sri Lanka","volume":"11","author":"Gunarathna","year":"2023","journal-title":"Glob Health Sci Pract"},{"key":"2025121410250252000_14.10.e082798.35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185883","article-title":"Productivity cost due to postpartum ill health: A cross-sectional study in Sri Lanka","volume":"12","author":"Wickramasinghe","year":"2017","journal-title":"PLoS ONE"},{"key":"2025121410250252000_14.10.e082798.36","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-020-03056-x","article-title":"The Rajarata Pregnancy Cohort (RaPCo): study protocol","volume":"20","author":"Agampodi","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025121410250252000_14.10.e082798.37","unstructured":"Department of Census and Statistics of Sri Lanka . Household income and expenditure survey 2016 final report. 2018.6."},{"key":"2025121410250252000_14.10.e082798.38","doi-asserted-by":"publisher","DOI":"10.4038\/amj.v17i1.7757"},{"key":"2025121410250252000_14.10.e082798.39","doi-asserted-by":"crossref","first-page":"700","DOI":"10.12688\/f1000research.53320.1","article-title":"Economic burden of out-of-pocket expenditure, productivity cost during pregnancy and COVID-19 impact on household economy in a cohort of pregnant women in Anuradhapura District, Sri Lanka; A study protocol","volume":"10","author":"Gunarathne","year":"2021","journal-title":"F1000Res"},{"key":"2025121410250252000_14.10.e082798.40","unstructured":"Exchange Rates UK . USD LKR Historical Chart for Year 2019 & 2020; US Dollar to Sri Lankan Rupee Spot Exchange Rates for 2019 and 2020, 2020. Available: https:\/\/www.exchangerates.org.uk\/USD-LKR-spot-exchange-rates-history-2020.html [Accessed 21 Jul 2022]."},{"key":"2025121410250252000_14.10.e082798.41","unstructured":"Department of Census and Statistics . Poverty indicators-2019. 2022. Available: http:\/\/www.statistics.gov.lk\/Poverty\/staticalinformation"},{"key":"2025121410250252000_14.10.e082798.42","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-017-1249-0","article-title":"The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again - results from a cross-sectional study","volume":"17","author":"Heitmann","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025121410250252000_14.10.e082798.43","unstructured":"Gunarathne SP , Agampodi TC , Wickramasinghe ND . Traveling cost for health service utilization in early pregnancy evidence from the rajarata pregnancy cohort. In: International Symposium of Rajarata University (ISYMRU 2021). Mihintale, Sri Lanka: Rajarata University of Sri Lanka, 2021: 142. Available: http:\/\/repository.rjt.ac.lk\/handle\/123456789\/3463"},{"key":"2025121410250252000_14.10.e082798.44","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070214","article-title":"Impact of COVID-19 pandemic on health service utilisation and household economy of pregnant and postpartum women: a cross-sectional study from rural Sri Lanka","volume":"13","author":"Gunarathna","year":"2023","journal-title":"BMJ Open"},{"key":"2025121410250252000_14.10.e082798.45","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01377-1"},{"key":"2025121410250252000_14.10.e082798.46","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-019-7848-0","article-title":"The association between social capital and quality of life among a sample of Iranian pregnant women","volume":"19","author":"RezaeiNiaraki","year":"2019","journal-title":"BMC Public Health"},{"key":"2025121410250252000_14.10.e082798.47","doi-asserted-by":"crossref","DOI":"10.1186\/s12978-017-0349-7","article-title":"Social capital and health during pregnancy; an in-depth exploration from rural Sri Lanka","volume":"14","author":"Agampodi","year":"2017","journal-title":"Reprod Health"},{"key":"2025121410250252000_14.10.e082798.48","article-title":"Interventions for nausea and vomiting in early pregnancy","volume":"2015","author":"Matthews","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121410250252000_14.10.e082798.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.03.009"},{"key":"2025121410250252000_14.10.e082798.50","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d3606","article-title":"Management of nausea and vomiting in pregnancy","volume":"342","author":"Jarvis","year":"2011","journal-title":"BMJ"},{"key":"2025121410250252000_14.10.e082798.51","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122605"},{"key":"2025121410250252000_14.10.e082798.52","unstructured":"Piwko C , Koren G , Babashov V , et al . Economic burden of nausea and vomiting of pregnancy in the USA. J Popul Ther Clin Pharmacol 2013;149\u201360."},{"key":"2025121410250252000_14.10.e082798.53","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1185\/030079907X178739","article-title":"The weekly cost of nausea and vomiting of pregnancy for women calling the Toronto Motherisk Program","volume":"23","author":"Piwko","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"2025121410250252000_14.10.e082798.54","unstructured":"American College of Obstetricians and Gynecologists . Bleeding during pregnancy. In: Frequently Asked Questions: Bleeding During Pregnancy. 2021. Available: https:\/\/www.acog.org\/womens-health\/faqs\/bleeding-during-pregnancy [accessed 14 Jun 2023]."},{"key":"2025121410250252000_14.10.e082798.55","first-page":"283","article-title":"Early pregnancy bleeding","volume":"45","author":"Breeze","year":"2016","journal-title":"Aust Fam Physician"},{"key":"2025121410250252000_14.10.e082798.56","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-021-04341-z","article-title":"Prevalence and aetiologies of anaemia among first trimester pregnant women in Sri Lanka; the need for revisiting the current control strategies","volume":"22","author":"Amarasinghe","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025121410250252000_14.10.e082798.57","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzac061.038"},{"key":"2025121410250252000_14.10.e082798.58","doi-asserted-by":"crossref","first-page":"e548","DOI":"10.1016\/S2214-109X(18)30078-0","article-title":"Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis","volume":"6","author":"Daru","year":"2018","journal-title":"Lancet Glob Health"},{"key":"2025121410250252000_14.10.e082798.59","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1111\/jog.14834","article-title":"Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis","volume":"47","author":"Omotayo","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"2025121410250252000_14.10.e082798.60","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/0276146720906539","article-title":"Household Purchasing Productivity: Concept and Consequences","volume":"40","author":"Shaw","year":"2020","journal-title":"J Macromarketing"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-082798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:25:17Z","timestamp":1765736717000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-082798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,29]]},"published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1136\/bmjopen-2023-082798"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-082798","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}