{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:32:48Z","timestamp":1765603968423,"version":"3.48.0"},"reference-count":33,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["NIHR204398"],"award-info":[{"award-number":["NIHR204398"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,12,22]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In the UK, 1600 babies die every year before, during or immediately after birth at 20\u201328 weeks\u2019 gestation. This bereavement has a similar impact on parental physical and psychological well-being to late stillbirth (&gt;28 weeks\u2019 gestation). Improved understanding of potentially modifiable risk factors for late stillbirth (including supine going-to-sleep position) has influenced international clinical practice. Information is now urgently required to similarly inform clinical practice and aid decision-making by expectant mothers\/parents, addressing inequalities in pregnancy loss between 20 and 28 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      This study focuses on what portion of risk of pregnancy loss 20\u201328 weeks\u2019 gestation is associated with exposures amenable to public health campaigns\/antenatal care adaptation. A case\u2013control study of non-anomalous singleton baby loss (via miscarriage, stillbirth or early neonatal death) 20\n                      <jats:sup>+0<\/jats:sup>\n                      to 27\n                      <jats:sup>+6<\/jats:sup>\n                      (n=316) and randomly selected control pregnancies (2:1 ratio; n=632) at group-matched gestations will be conducted. Data is collected via participant recall (researcher-administered questionnaire) and extraction from contemporaneous medical records. Unadjusted\/confounder-adjusted ORs will be calculated. Exposures associated with early stillbirth at OR\u22651.5\u2009will be detectable (p&lt;0.05, \u03b2&gt;0.80) assuming exposure prevalence of 30%\u201360%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>NHS research ethical approval has been obtained from the London\u2014Seasonal research ethics committee (23\/LO\/0622). The results will be presented at international conferences and published in peer-reviewed open-access journals. Information from this study will enable development of antenatal care and education for healthcare professionals and pregnant people to reduce risk of early stillbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06005272\">NCT06005272<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-082835","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T07:16:13Z","timestamp":1705562173000},"page":"e082835","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mothers working to prevent early stillbirth study (MiNESS 20\u201328): a case\u2013control study protocol"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct06005272","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06005272","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-7845","authenticated-orcid":false,"given":"Alexander Edward","family":"Heazell","sequence":"first","affiliation":[{"name":"Maternal and Fetal Health Research Centre, The University of Manchester, Manchester, UK"},{"name":"St. Mary's Hospital, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-4677","authenticated-orcid":false,"given":"Jack","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Katie","family":"Morris","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-7583","authenticated-orcid":false,"given":"Nigel","family":"Simpson","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy K","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Leicester, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasina","family":"Stacey","sequence":"additional","affiliation":[{"name":"Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Storey","sequence":"additional","affiliation":[{"name":"International Stillbirth Alliance, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-497X","authenticated-orcid":false,"given":"Lucy","family":"Higgins","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, The University of Manchester, Manchester, UK"},{"name":"St. Mary's Hospital, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"2025121221300752000_14.1.e082835.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00836-3"},{"key":"2025121221300752000_14.1.e082835.2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/1471-0528.14972","article-title":"Healthcare and wider societal implications of Stillbirth: a population-based cost-of-illness study","volume":"125","author":"Campbell","year":"2018","journal-title":"BJOG"},{"key":"2025121221300752000_14.1.e082835.3","unstructured":"WHO, UNICEF . 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