{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:15:09Z","timestamp":1765703709206,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["5\/7\/91\/MH\/Adhoc\/2020-RBMCH"],"award-info":[{"award-number":["5\/7\/91\/MH\/Adhoc\/2020-RBMCH"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,4,26]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Objective<\/jats:title>\n To estimate the prevalence of neural tube defects among all birth outcomes in Odisha during 2016\u20132022. Additionally, to estimate the identification rate of neural tube defects during Pradhan Mantri Surakshit Matritva Abhiyan sessions.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A population-based cross-sectional study with a household survey for neural tube defects using pictorial card as well as a hospital-based study for antenatal ultrasonography data.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n The sample population was selected through multistage random sampling. In the first stage, one district from each zone was selected randomly. In the second stage, using simple random sampling, one community health centre and one urban primary health centre were selected from each district. In the third stage, the population from a block and ward were picked from the selected rural and urban settings, respectively.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n All married women in the reproductive age group (18\u201349 years) residing in these cluster villages in the selected districts were enrolled.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study surveyed 49\u2009215\u2009women and recorded 50\u2009196 birth outcomes, including 49\u2009174 live births, 890 stillbirths and 132 medical terminations of pregnancy. A total of 30 neural tube defect cases were detected. The overall prevalence rate of neural tube defect was 0.59 per 1000 birth outcomes. Spina bifida was the most prevalent neural tube defect with the prevalence of, followed by anencephaly and encephalocele. Despite 26\u2009860 mothers receiving antenatal ultrasonography Pradhan Mantri Surakshit Matritva Abhiyan session, data on neural tube defects and other birth defects detected through these scans is unavailable.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study found a low prevalence of neural tube defect in Odisha, which is far lower compared with the older studies from India. There is an urgent need to strengthen the quality of antenatal care services provided under Pradhan Mantri Surakshit Matritva Abhiyan through better training regarding anomaly scans and better data keeping at public healthcare facilities.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n CTRI\/2021\/06\/034487.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-083057","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T02:25:27Z","timestamp":1715912727000},"page":"e083057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of neural tube defect and its identification during antenatal period: a cross-sectional study in eastern Indian state"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-3966","authenticated-orcid":false,"given":"Santosh Kumar","family":"Mahalik","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Community Medicine & Family Medicine, All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash Bihari","family":"Pati","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipipuspa","family":"Rout","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhra","family":"Mallisha","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2025121401120638000_14.5.e083057.1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151586","article-title":"Describing the prevalence of neural tube defects worldwide: A systematic literature review","volume":"11","author":"Zaganjor","year":"2016","journal-title":"PLoS One"},{"key":"2025121401120638000_14.5.e083057.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264005","article-title":"Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: where are we in the prevention and what is the way forward","volume":"17","author":"Berhane","year":"2022","journal-title":"PLoS One"},{"key":"2025121401120638000_14.5.e083057.3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118961","article-title":"Wellcome Trust- PHFI folic acid project team. birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis","volume":"10","author":"Allagh","year":"2015","journal-title":"PLoS One"},{"key":"2025121401120638000_14.5.e083057.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00399-3"},{"key":"2025121401120638000_14.5.e083057.5","unstructured":"Ministry of Health and Family Welfare GoI . Pradhan Mantri Surakshit Matriva Abhiyan, Available: https:\/\/pmsma.mohfw.gov.in\/about-scheme\/#about https:\/\/pmsma.nhp.gov.in\/resources\/"},{"key":"2025121401120638000_14.5.e083057.6","unstructured":"Ministry of Health and Family Welfare GoI . Pradhan Mantri Surakshit Matriva Abhiyan, Available: https:\/\/pmsma.nhp.gov.in\/wp-content\/uploads\/2016\/09\/Pradhan_Mantri_Surakshit Matritva_Abhiyan-2.pdf"},{"key":"2025121401120638000_14.5.e083057.7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bdra.23578","article-title":"Prevalence of neural tube defects in a rural area of North India from 2001 to 2014: A population-based survey","volume":"109","author":"Kant","year":"2017","journal-title":"Birth Defects Res"},{"key":"2025121401120638000_14.5.e083057.8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/1793-5482.175628","article-title":"High incidence of neural tube defects in northern part of India","volume":"11","author":"Rai","year":"2016","journal-title":"Asian J Neurosurg"},{"key":"2025121401120638000_14.5.e083057.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67319-9"},{"key":"2025121401120638000_14.5.e083057.10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF02722422","article-title":"Study of 1,26,266 consecutive births for major congenital defects","volume":"56","author":"Choudhury","year":"1989","journal-title":"Indian J Pediatr"},{"key":"2025121401120638000_14.5.e083057.11","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23153"},{"key":"2025121401120638000_14.5.e083057.12","doi-asserted-by":"crossref","unstructured":"Murphy ME , Westmark CJ . Folic acid Fortification and neural tube defect risk: analysis of the food Fortification initiative Dataset. Nutrients 2020;12. doi:10.3390\/nu12010247","DOI":"10.3390\/nu12010247"},{"key":"2025121401120638000_14.5.e083057.13","unstructured":"Congenital disorders. n.d. 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