{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:57:05Z","timestamp":1768431425383,"version":"3.49.0"},"reference-count":40,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,1,21]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>A large number of patients with non-obese non-alcoholic fatty liver disease (NAFLD) in China remain undiagnosed and untreated due to insufficient awareness and ineffective pharmacotherapy. Therefore, a convenient, predictive marker and diagnostic tools are imperative. This study aimed to investigate the ability of the triglyceride glucose index (TyG) in predicting non-obese NAFLD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>An observational cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Department of Health Management, large urban academic medical centre and DRYAD database data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>This study included 456 patients with non-obese NAFLD and matched 456 non-fatty liver controls according to age, sex and body mass index (BMI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>The receiver operating characteristic (ROC) curve was used to evaluate the predictive role of the TyG index in non-obese NAFLD. Based on the TyG index, a clinical prediction model for non-obese NAFLD was constructed, then the prediction model was verified by the DRYAD database (n=11 562).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>TyG in non-obese NAFLD was higher than that in controls (9.00 (8.66\u20139.40) vs 8.46 (8.10\u20138.83), p&lt;0.001). Logistic regression analysis showed that TyG was an independent risk factor for non-obese NAFLD (OR=9.03, 95% CI: 5.46 to 14.94, p&lt;0.001). ROC analysis showed that the area under the curve (AUC) was 0.78, the sensitivity was 82.5%, the specificity was 60.5%. Based on the TyG index, sex, age and BMI, the AUC of the predictive model for non-obese NAFLD was 0.78 (95% CI: 0.75 to 0.81, p&lt;0.001). Using the DRYAD database to verify the prediction model, the AUC of the verification group was 0.85 (95% CI: 0.84 to 0.86, p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The high level of the TyG may be an independent risk factor for non-obese NAFLD. The prediction model for non-obese NAFLD based on the TyG index has good clinical prediction value.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-083686","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:25:19Z","timestamp":1744161919000},"page":"e083686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive value of triglyceride glucose index in non-obese non-alcoholic fatty liver disease"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-9083","authenticated-orcid":false,"given":"Xiaopeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhongYan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Health Management, Daping Hospital, Army Medical University, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"2025101812035143000_15.4.e083686.1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.31150","article-title":"Epidemiological Features of NAFLD From 1999 to 2018 in 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