{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:42:59Z","timestamp":1780051379390,"version":"3.53.1"},"reference-count":26,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03 DE028505-02"],"award-info":[{"award-number":["R03 DE028505-02"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01-NR012459"],"award-info":[{"award-number":["R01-NR012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R396_1114"],"award-info":[{"award-number":["R396_1114"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R592_0515"],"award-info":[{"award-number":["R592_0515"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R592_0717"],"award-info":[{"award-number":["R592_0717"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01-AG-6-2101"],"award-info":[{"award-number":["N01-AG-6-2101"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01-AG-6-2103"],"award-info":[{"award-number":["N01-AG-6-2103"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01-AG-6-2106"],"award-info":[{"award-number":["N01-AG-6-2106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG028050"],"award-info":[{"award-number":["R01-AG028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/13\/41\/30304"],"award-info":[{"award-number":["PG\/13\/41\/30304"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/13\/86\/30546"],"award-info":[{"award-number":["PG\/13\/86\/30546"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/08\/013\/25942"],"award-info":[{"award-number":["RG\/08\/013\/25942"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/13\/16\/30528"],"award-info":[{"award-number":["RG\/13\/16\/30528"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/19\/4\/34452"],"award-info":[{"award-number":["RG\/19\/4\/34452"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,1,14]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the association of poor oral health with appetite loss and deterioration in appetite longitudinally in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional and longitudinal observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Data came from two population-based cohorts of older adults from the UK and USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The British Regional Heart Study (BRHS) included men (n=1348, age=79\u201387 years in 2016\u20132017 at baseline and 81\u201389 years in 2018\u20132019 at follow-up). The US Health, Aging and Body Composition (HABC) Study included men and women (n=2998, age=71\u201377 years in 1998\u20131999 at baseline and 73\u201379 years in 2000\u20132001 at follow-up). Objective and self-reported oral health measures were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Loss of appetite, at baseline and 2-year follow-up, was based on the Simplified Nutrition Assessment Questionnaire in the BRHS and self-reported appetite loss in the HABC Study. In the BRHS, changes in oral health over time were also assessed. Logistic regression models were adjusted for sociodemographic, behavioural and health-related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cross-sectionally, poor self-rated oral health, dry mouth, eating or chewing difficulty, food avoidance and cumulative oral health problems were associated with appetite loss in both studies. Longitudinally, in the BRHS, dry mouth (OR=2.12 (95% CI=1.40 to 3.20)), eating or chewing difficulty (OR=1.59 (95% CI=1.02 to 2.48)), food avoidance (OR=1.75 (95% CI=1.16 to 2.65)) and cumulative oral health problems (OR=2.84 (95% CI=1.80 to 4.50)) at baseline were associated with sustained poor\/deterioration in appetite over the follow-up, after full adjustment. In the HABC Study, self-rated oral health ((OR=1.13 (95% CI=1.01 to 1.27)), tooth loss (OR=1.78 (95% CI=1.15 to 2.76)), dry mouth (OR=1.76 (95% CI=1.02 to 3.03)), eating or chewing difficulty (OR=1.88 (95% CI=1.41 to 2.50)) and cumulative oral health problems (OR=1.89 (95% CI=1.33 to 2.70)) at baseline were associated with sustained poor\/deterioration in appetite during follow-up. In the BRHS, sustained poor\/deterioration in oral health markers (self-rated oral health, dry mouth, eating or chewing difficulty, food avoidance, loose denture\/s) over the follow-up were associated with sustained poor\/deterioration of appetite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral health is a potentially important contributor to maintaining good appetite in older age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-083973","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T09:50:50Z","timestamp":1738576250000},"page":"e083973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association between poor oral health and deterioration of appetite in older age: results from longitudinal analyses of two prospective cohorts from the UK and USA"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-5795","authenticated-orcid":false,"given":"Suruchi G","family":"Ganbavale","sequence":"first","affiliation":[{"name":"Newcastle University Population Health Sciences Institute, Newcastle Upon Tyne, UK"},{"name":"Department of Public Health, Policy and Systems, University of Liverpool Institute of Population Health, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Newcastle University Population Health Sciences Institute, Newcastle Upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Mathers","sequence":"additional","affiliation":[{"name":"Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olia","family":"Papacosta","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H","family":"Whincup","sequence":"additional","affiliation":[{"name":"City St George's, University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Weyant","sequence":"additional","affiliation":[{"name":"Dental Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9484-9977","authenticated-orcid":false,"given":"S Goya","family":"Wannamethee","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena E","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2025121603251842000_15.2.e083973.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(88)80004-6"},{"key":"2025121603251842000_15.2.e083973.2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.appet.2016.06.037","article-title":"A scoping review of anorexia of aging correlates and their relevance to population health interventions","volume":"105","author":"Roy","year":"2016","journal-title":"Appetite"},{"key":"2025121603251842000_15.2.e083973.3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ageing\/afaa014","article-title":"New horizons in appetite and the anorexia of ageing","volume":"49","author":"Cox","year":"2020","journal-title":"Age Ageing"},{"key":"2025121603251842000_15.2.e083973.4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jcsm.13186","article-title":"Association of anorexia\/appetite loss with malnutrition and mortality in older populations: A systematic literature review","volume":"14","author":"Fielding","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2025121603251842000_15.2.e083973.5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12603-021-1703-6","article-title":"Editorial: Anorexia of Ageing: Pathway to Frailty and Sarcopenia","volume":"26","author":"Merchant","year":"2022","journal-title":"J Nutr Health Aging"},{"key":"2025121603251842000_15.2.e083973.6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12603-019-1159-0","article-title":"Anorexia of Aging - An Updated Short Review","volume":"23","author":"Jadczak","year":"2019","journal-title":"J Nutr Health Aging"},{"key":"2025121603251842000_15.2.e083973.7","doi-asserted-by":"publisher","DOI":"10.1300\/J052v26n01_02"},{"key":"2025121603251842000_15.2.e083973.8","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/ggi.13792","article-title":"Association between anorexia and poor chewing ability among community\u2010dwelling older adults in Japan","volume":"19","author":"Kimura","year":"2019","journal-title":"Geriatrics Gerontology Int"},{"key":"2025121603251842000_15.2.e083973.9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/idj.12329","article-title":"Oral health for an ageing population: the importance of a natural dentition in older adults","volume":"67 Suppl 2","author":"M\u00fcller","year":"2017","journal-title":"Int Dent J"},{"key":"2025121603251842000_15.2.e083973.10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ger.12600","article-title":"Poor oral health and anorexia in older rehabilitation patients","volume":"39","author":"Nomoto","year":"2022","journal-title":"Gerodontology"},{"key":"2025121603251842000_15.2.e083973.11","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-021-02169-y","article-title":"Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP)","volume":"21","author":"Takehara","year":"2021","journal-title":"BMC Geriatr"},{"key":"2025121603251842000_15.2.e083973.12","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1093\/ije\/dyac122","article-title":"Cohort Profile Update: The British Regional Heart Study 1978-2018: 40 years of follow-up of older British men","volume":"52","author":"Kimble","year":"2023","journal-title":"Int J Epidemiol"},{"key":"2025121603251842000_15.2.e083973.13","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1093\/pubmed\/fdy068","article-title":"Socioeconomic disadvantage across the life-course and oral health in older age: findings from a longitudinal study of older British men","volume":"40","author":"Ramsay","year":"2018","journal-title":"J Public Health (Bangkok)"},{"key":"2025121603251842000_15.2.e083973.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009476","article-title":"Burden of poor oral health in older age: findings from a population-based study of older British men","volume":"5","author":"Ramsay","year":"2015","journal-title":"BMJ Open"},{"key":"2025121603251842000_15.2.e083973.15","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12094"},{"key":"2025121603251842000_15.2.e083973.16","first-page":"12","article-title":"The Xerostomia Inventory: a multi-item approach to measuring dry mouth","volume":"16","author":"Thomson","year":"1999","journal-title":"Community Dent Health"},{"key":"2025121603251842000_15.2.e083973.17","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/ajcn\/82.5.1074","article-title":"Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents","volume":"82","author":"Wilson","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"2025121603251842000_15.2.e083973.18","unstructured":"Office of Population Censuses and Surveys . Classification of occupations. London:HM Stationary Office, 1970."},{"key":"2025121603251842000_15.2.e083973.19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jgs.15175","article-title":"Influence of Poor Oral Health on Physical Frailty: A Population-Based Cohort Study of Older British Men","volume":"66","author":"Ramsay","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"2025121603251842000_15.2.e083973.20","doi-asserted-by":"crossref","first-page":"e777","DOI":"10.1016\/S2666-7568(22)00222-7","article-title":"Association between oral health markers and decline in muscle strength and physical performance in later life: longitudinal analyses of two prospective cohorts from the UK and the USA","volume":"3","author":"Kimble","year":"2022","journal-title":"Lancet Healthy Longev"},{"key":"2025121603251842000_15.2.e083973.21","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv141"},{"key":"2025121603251842000_15.2.e083973.22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1017\/S0007114521000180","article-title":"Poor oral health and the association with diet quality and intake in older people in two studies in the UK and USA","volume":"126","author":"Kotronia","year":"2021","journal-title":"Br J Nutr"},{"key":"2025121603251842000_15.2.e083973.23","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1998.0423"},{"key":"2025121603251842000_15.2.e083973.24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036557","article-title":"The impact of oral health on taste ability in acutely hospitalized elderly","volume":"7","author":"Solemdal","year":"2012","journal-title":"PLoS ONE"},{"key":"2025121603251842000_15.2.e083973.25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1532-5415.2002.50123.x","article-title":"Xerostomia and the Geriatric Patient","volume":"50","author":"Ship","year":"2002","journal-title":"J American Geriatrics Society"},{"key":"2025121603251842000_15.2.e083973.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(99)00002-0"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-083973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:25:28Z","timestamp":1765884328000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-083973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,3]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bmjopen-2024-083973"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-083973","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}