{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:38:51Z","timestamp":1765010331554,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Northern Alberta Academic Family Medicine Fund","award":["R14P13, R17P02, R18P23"],"award-info":[{"award-number":["R14P13, R17P02, R18P23"]}]},{"name":"Alberta Innovates through Enhancing Alberta Primary Care Research Networks","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"\n Introduction<\/jats:title>\n Although antihypertensive medication use is common among frail older adults, observational studies in this population suggest blood pressure (BP) lowering may convey limited benefit and perhaps even harm. This protocol describes an antihypertensive deprescribing trial in frail older adults powered for mortality and morbidity outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n \n Design:<\/jats:italic>\n Prospective, parallel, randomised, open-label pragmatic trial.\n <\/jats:p>\n \n Participants:<\/jats:italic>\n Long-term care (LTC) residents \u226570 years of age, diagnosed with hypertension, with mean systolic BP <135\u2009mm Hg, \u22651 daily antihypertensive medication and no history of congestive heart failure.\n <\/jats:p>\n \n Setting:<\/jats:italic>\n 18 LTC facilities in Alberta, Canada, with eligible residents identified using electronic health services data.\n <\/jats:p>\n \n Intervention:<\/jats:italic>\n All non-opted-out eligible residents are randomised centrally by a provincial health data steward to either usual care, or continually reducing antihypertensives provided an upper systolic threshold of 145\u2009mm Hg is not exceeded. Deprescribing is carried out by pharmacists\/nurse practitioners, using an investigator-developed algorithm.\n <\/jats:p>\n \n Follow-up:<\/jats:italic>\n Provincial healthcare databases tracking hospital, continuing care and community medical services.\n <\/jats:p>\n \n Primary outcome:<\/jats:italic>\n All-cause mortality.\n <\/jats:p>\n \n Secondary outcome:<\/jats:italic>\n Composite of all-cause mortality or all-cause unplanned hospitalisation\/emergency department visit.\n <\/jats:p>\n \n Tertiary outcomes:<\/jats:italic>\n All-cause unplanned hospitalisation\/emergency department visit, non-vertebral fracture, renal insufficiency and cost of care. Also, as assessed roughly 135-days postrandomisation, fall in the last 30 days, worsening cognition, worsening activities of daily living and skin ulceration.\n <\/jats:p>\n \n Process outcomes:<\/jats:italic>\n Number of daily antihypertensive medications (broken down by antihypertensive class) and average systolic and diastolic BP over study duration.\n <\/jats:p>\n \n Primary outcome analysis:<\/jats:italic>\n Cox proportional hazards survival analysis.\n <\/jats:p>\n \n Sample size:<\/jats:italic>\n The trial will continue until observation of 247 primary outcome events has occurred.\n <\/jats:p>\n \n Current status:<\/jats:italic>\n Enrolment is ongoing with ~400 randomisations to date (70% female, mean age 86 years).\n <\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n Ethics approval was obtained from the University of Alberta Health Ethics Review Board (Pro00097312) and results will be published in a peer-reviewed journal.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n \n NCT05047731<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-084619","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T22:41:39Z","timestamp":1724971299000},"page":"e084619","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Antihypertensive deprescribing in frail long-term care residents (OptimizeBP): protocol for a prospective, randomised, open-label pragmatic trial"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05047731","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-4955","authenticated-orcid":false,"given":"Roni Y","family":"Kraut","sequence":"first","affiliation":[{"name":"Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Pragmatic Trials Collaborative, University of 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