{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:34:35Z","timestamp":1765712075331,"version":"3.48.0"},"reference-count":57,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,11,3]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The autoimmune encephalitides (AE) are a heterogeneous group of neurological disorders with significant morbidity and healthcare costs. Despite advancements in understanding their pathophysiology, uncertainties persist regarding long-term prognosis and optimal management. This study aims to address these gaps, focusing on immunotherapeutic strategies, neoplastic associations and functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The Retrospective Linkage Study of Autoimmune Encephalitis project will use data linkage techniques to establish a retrospective 10-year population cohort of Australian patients with AE. Two cohorts will be analysed, the Reference Cohort (clinically confirmed AE cases obtained from hospital medical records, n=145) and the Operationally Defined Cohort (AE cases identified through administrative coding data, n\u22485000). Univariate statistical methods will identify candidate coding elements for use in the operational case definition and multivariate models and evaluation methods used to identify and internally validate the optimal coding algorithms. The two study cohorts will be analysed separately due to the high likelihood of overlap. Primary outcomes include relapse rate, prevalence and control of epilepsy, cognitive disability, poor educational attainment, delayed tumour diagnosis and mortality. Statistical analyses, including random mixed-effects regression models, will assess treatment effects, covariates and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This project has been approved by the leading investigators\u2019 institutional Human Research Ethics Committee (HREC), the St Vincent\u2019s Hospital Melbourne HREC, as well as the Australian Institute of Health and Welfare HREC and relevant jurisdictional HRECs where required. The dissemination of findings through peer-reviewed publications and patient advocacy channels will maximise the impact of this research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-084664","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T21:50:37Z","timestamp":1733435437000},"page":"e084664","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["RESILIENCE (Retrospective Linkage Study of Autoimmune Encephalitis): protocol for an Australian retrospective cohort study of outcomes in autoimmune encephalitis using data linkage techniques"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-4347","authenticated-orcid":false,"given":"Amy Jean","family":"Halliday","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia"},{"name":"Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bundell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Immunology, Clinical Immunology, PathWest, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"McLean-Tooke","sequence":"additional","affiliation":[{"name":"Department of Laboratory Immunology, Clinical Immunology, PathWest, Nedlands, Western Australia, Australia"},{"name":"Department of Clinical Immunology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gillis","sequence":"additional","affiliation":[{"name":"Autoimmune-Immunobiology Laboratory, Division of Immunology, Queensland Public Health and Scientific Services, Queensland Health, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerri M","family":"Prain","sequence":"additional","affiliation":[{"name":"Autoimmune-Immunobiology Laboratory, Division of Immunology, Queensland Public Health and Scientific Services, Queensland Health, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Bryson","sequence":"additional","affiliation":[{"name":"Autoimmune-Immunobiology Laboratory, Division of Immunology, Queensland Public Health and Scientific Services, Queensland Health, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Gillinder","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia"},{"name":"Neurology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Brown","sequence":"additional","affiliation":[{"name":"Centre for Allergy and Immunology Research, Institute of Clinical Pathology and Medical Research, Westmead, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudarshini","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Translational Neuroimmunology Group, Kids Neuroscience Centre, Kids Research at the Children\u2019s Hospital at Westmead, Westmead, New South Wales, Australia"},{"name":"Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Department of Neurology, Concord Hospital, Sydney, New South Wales, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Dale","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children\u2019s Hospital at Westmead, Sydney, New South Wales, Australia"},{"name":"Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Brilot","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children\u2019s Hospital at Westmead, Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerissa","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Lawn","sequence":"additional","affiliation":[{"name":"Western Australian Adult Epilepsy Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"},{"name":"School of Medicine, Royal Perth Hospital Unit, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Australian Adult Comprehensive Epilepsy Centres Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Camacho","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendyl Jude","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia"},{"name":"Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"2025121403322300000_14.12.e084664.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"2025121403322300000_14.12.e084664.2","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000891","article-title":"Direct economic burden of patients with autoimmune encephalitis in western China","volume":"7","author":"Li","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2025121403322300000_14.12.e084664.3","first-page":"e964","article-title":"Autoimmune encephalitis: A costly condition","volume":"92","author":"Cohen","year":"2019","journal-title":"Neurology (ECronicon)"},{"key":"2025121403322300000_14.12.e084664.4","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1115720"},{"key":"2025121403322300000_14.12.e084664.5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325300"},{"key":"2025121403322300000_14.12.e084664.6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26241"},{"key":"2025121403322300000_14.12.e084664.7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/jamaneurol.2021.0477","article-title":"Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis","volume":"78","author":"Binks","year":"2021","journal-title":"JAMA Neurol"},{"key":"2025121403322300000_14.12.e084664.8","doi-asserted-by":"crossref","first-page":"120124","DOI":"10.1016\/j.jns.2021.120124","article-title":"Residual symptoms and long-term outcomes after all-cause autoimmune encephalitis in adults","volume":"434","author":"Abboud","year":"2022","journal-title":"J Neurol Sci"},{"key":"2025121403322300000_14.12.e084664.9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02708","article-title":"Management of Autoimmune Encephalitis: An Observational Monocentric Study of 38 Patients","volume":"9","author":"Macher","year":"2018","journal-title":"Front Immunol"},{"key":"2025121403322300000_14.12.e084664.10","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1007\/s00415-018-8970-0","article-title":"Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies","volume":"265","author":"Bost","year":"2018","journal-title":"J Neurol"},{"key":"2025121403322300000_14.12.e084664.11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yebeh.2018.02.025","article-title":"Late-onset anti-N-methyl-d-aspartate receptor encephalitis in China","volume":"84","author":"Zhang","year":"2018","journal-title":"Epilepsy Behav"},{"key":"2025121403322300000_14.12.e084664.12","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2020-002567"},{"key":"2025121403322300000_14.12.e084664.13","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00750-3"},{"key":"2025121403322300000_14.12.e084664.14","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70310-1"},{"key":"2025121403322300000_14.12.e084664.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03220.x"},{"key":"2025121403322300000_14.12.e084664.16","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"2025121403322300000_14.12.e084664.17","unstructured":"National Casemix & Classification Centre U of Wollongong, National Centre for Classification in Health (Australia) . The international statistical classification of diseases and related health problems: 10th revision: Australian modification (ICD-10-AM). 2013."},{"key":"2025121403322300000_14.12.e084664.18","unstructured":"National Centre for Classification in Health, World Health Organization . International statistical classification of diseases and related health problems. Australian classification of health interventions ACHI; 2019."},{"key":"2025121403322300000_14.12.e084664.19","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30488-0"},{"key":"2025121403322300000_14.12.e084664.20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24117"},{"key":"2025121403322300000_14.12.e084664.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.01.021"},{"key":"2025121403322300000_14.12.e084664.22","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.642078","article-title":"Characteristics and Prognosis of Autoimmune Encephalitis in the East of China: A Multi-Center Study","volume":"12","author":"Qiao","year":"2021","journal-title":"Front Neurol"},{"key":"2025121403322300000_14.12.e084664.23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.621599","article-title":"Neuronal Surface Antibody-Medicated Autoimmune Encephalitis (Limbic Encephalitis) in China: A Multiple-Center, Retrospective Study","volume":"12","author":"Shan","year":"2021","journal-title":"Front Immunol"},{"key":"2025121403322300000_14.12.e084664.24","doi-asserted-by":"crossref","first-page":"104697","DOI":"10.1016\/j.msard.2023.104697","article-title":"Factors influencing prognosis and relapse in patients with anti-N-methyl-D-aspartate receptor encephalitis","volume":"74","author":"Wu","year":"2023","journal-title":"Mult Scler Relat Disord"},{"key":"2025121403322300000_14.12.e084664.25","doi-asserted-by":"crossref","DOI":"10.1177\/17562864211073203","article-title":"Clinical characteristics, long-term functional outcomes and relapse of anti-LGI1\/Caspr2 encephalitis: a prospective cohort study in Western China","volume":"15","author":"Guo","year":"2022","journal-title":"Ther Adv Neurol Disord"},{"key":"2025121403322300000_14.12.e084664.26","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70253-2"},{"key":"2025121403322300000_14.12.e084664.27","doi-asserted-by":"crossref","first-page":"577899","DOI":"10.1016\/j.jneuroim.2022.577899","article-title":"Analysis of risk factors for a poor functional prognosis and relapse in patients with autoimmune encephalitis","volume":"369","author":"Yao","year":"2022","journal-title":"J Neuroimmunol"},{"key":"2025121403322300000_14.12.e084664.28","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000449"},{"key":"2025121403322300000_14.12.e084664.29","doi-asserted-by":"crossref","first-page":"108729","DOI":"10.1016\/j.yebeh.2022.108729","article-title":"Prevalence, risk factors, and prognosis of drug-resistant epilepsy in autoimmune encephalitis","volume":"132","author":"Wesselingh","year":"2022","journal-title":"Epilepsy Behav"},{"key":"2025121403322300000_14.12.e084664.30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.seizure.2021.09.007","article-title":"Predictors and prognoses of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis","volume":"92","author":"Chen","year":"2021","journal-title":"Seizure"},{"key":"2025121403322300000_14.12.e084664.31","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2018.33"},{"key":"2025121403322300000_14.12.e084664.32","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2019.00511","article-title":"Understanding Childhood Neuroimmune Diseases of the Central Nervous System","volume":"7","author":"Matricardi","year":"2019","journal-title":"Front Pediatr"},{"key":"2025121403322300000_14.12.e084664.33","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617722000509"},{"key":"2025121403322300000_14.12.e084664.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577471"},{"key":"2025121403322300000_14.12.e084664.35","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15429"},{"key":"2025121403322300000_14.12.e084664.36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/imj.12974","article-title":"Autoimmune encephalitis","volume":"46","author":"Newman","year":"2016","journal-title":"Intern Med J"},{"key":"2025121403322300000_14.12.e084664.37","doi-asserted-by":"crossref","DOI":"10.1007\/s11940-019-0550-9","article-title":"Diagnosis and Management of Autoimmune Dementia","volume":"21","author":"Sechi","year":"2019","journal-title":"Curr Treat Options Neurol"},{"key":"2025121403322300000_14.12.e084664.38","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1212\/WNL.0b013e3182a9585f","article-title":"Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients","volume":"81","author":"H\u00f6ftberger","year":"2013","journal-title":"Neurology (ECronicon)"},{"key":"2025121403322300000_14.12.e084664.39","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2020-002676"},{"key":"2025121403322300000_14.12.e084664.40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/WCO.0000000000001048","article-title":"Immunotherapy in autoimmune encephalitis","volume":"35","author":"Trewin","year":"2022","journal-title":"Curr Opin Neurol"},{"key":"2025121403322300000_14.12.e084664.41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaut.2018.10.014","article-title":"Prognosticating autoimmune encephalitis: A systematic review","volume":"96","author":"Broadley","year":"2019","journal-title":"J Autoimmun"},{"key":"2025121403322300000_14.12.e084664.42","unstructured":"Trewin D . SEIFA 2016 Technical Paper (5). 2016 p. 39. Report No.: ABS Catalogue No. 2033.0.55.001."},{"key":"2025121403322300000_14.12.e084664.43","unstructured":"Harris B , Craike M , Dunkin R , et al . Is medicare fair? I. the distribution of medicare benefits across the states and territories. (Mitchell institute policy issues paper). Report no.: 2\u20132019. Melbourne Victoria University; 2019."},{"key":"2025121403322300000_14.12.e084664.44","unstructured":"Health expenditure Australia 2021-22. (Health expenditure Australia). Canberra Australian Institute of Health and Welfare; 2023."},{"key":"2025121403322300000_14.12.e084664.45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yebeh.2015.06.031","article-title":"Development and validation of an epidemiologic case definition of epilepsy for use with routinely collected Australian health data","volume":"51","author":"Tan","year":"2015","journal-title":"Epilepsy Behav"},{"key":"2025121403322300000_14.12.e084664.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00341-9"},{"key":"2025121403322300000_14.12.e084664.47","doi-asserted-by":"crossref","unstructured":"Gastaldi M , Mariotto S , Giannoccaro MP , et al . Subgroup comparison according to clinical phenotype and serostatus in autoimmune encephalitis: a multicenter retrospective study. Eur J Neurol 2019. doi:10.1111\/ene.14139","DOI":"10.1111\/ene.14139"},{"key":"2025121403322300000_14.12.e084664.48","unstructured":"SA NT DataLink . Integrated South Australian activity collection data quality statemen. 2010. Available: https:\/\/www.phrn.org.au\/media\/81302\/dqs_isaac_may2010_v100.pdf"},{"key":"2025121403322300000_14.12.e084664.49","unstructured":"Government of Western Australia Department of Health . Data quality statement: hospital morbidity data collection. 2020. Available: https:\/\/www.datalinkage-wa.org.au\/wp-content\/uploads\/2020\/09\/Data-Quality-Statement_HMDC_Aug2020_V1.0.pdf"},{"key":"2025121403322300000_14.12.e084664.50","unstructured":"SA NT DataLink . Emergency department data collection data quality statement. 2010. Available: https:\/\/www.phrn.org.au\/media\/81300\/dqs_eddc_may2010_v100.pdf"},{"key":"2025121403322300000_14.12.e084664.51","unstructured":"Government of Western Australia Department of Health . Data quality statement: emergency department data collection. 2020. Available: https:\/\/www.datalinkage-wa.org.au\/wp-content\/uploads\/2020\/09\/Data-Quality-Statement_EDDC_Aug2020_V1.0.pdf"},{"key":"2025121403322300000_14.12.e084664.52","unstructured":"Australian Institute of Health and Welfare . Disability services national minimum data set (DS NMDS) - data quality statement. Report no.: 728139. 2020. Available: https:\/\/meteor.aihw.gov.au\/content\/index.phtml\/itemId\/728139"},{"key":"2025121403322300000_14.12.e084664.53","unstructured":"Disability services national minimum data set 2018-19; quality statement. 2021. Available: https:\/\/meteor.aihw.gov.au\/content\/index.phtml\/itemId\/728139"},{"key":"2025121403322300000_14.12.e084664.54","unstructured":"Australian cancer database 2011 data quality statement. 2021. Available: https:\/\/meteor.aihw.gov.au\/content\/index.phtml\/itemId\/586979"},{"key":"2025121403322300000_14.12.e084664.55","unstructured":"The social research centre. Australian early development census data user guide. 2014."},{"key":"2025121403322300000_14.12.e084664.56","unstructured":"Jason P , Bentley NN . The quality of record linkage between population-based birth and children\u2019s early child development and school test result (NAPLAN) records in New South Wales, Australia. Sydney, New South Wales, Australia Menzies Centre for Health Policy, School of Public Health, University of Sydney; 2017. Available: https:\/\/ses.library.usyd.edu.au\/bitstream\/handle\/2123\/17823\/Bentley2017_Data%20Linkage%20Technical%20Report.pdf?sequence=4&isAllowed=y"},{"key":"2025121403322300000_14.12.e084664.57","unstructured":"National Death Index (NDI) . Data quality statement. 2021. Available: https:\/\/meteor.aihw.gov.au\/content\/index.phtml\/itemId\/480010"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-084664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:32:38Z","timestamp":1765711958000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-084664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,5]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bmjopen-2024-084664"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-084664","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}