{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:24:53Z","timestamp":1789604693316,"version":"build-2803163510"},"reference-count":25,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Wolff GmbH & Co. KG","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,7,23]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Data on the population-based epidemiology of hyperhidrosis (HH) are scarce. This study investigated the epidemiology and healthcare of HH in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Claims data of adult persons insured by a German statutory health insurance (DAK-Gesundheit) between 2016 and 2020 were analysed. Included were persons aged 18 years and older with a diagnosis of HH (confirmed inpatient or outpatient diagnosis in the observation year) who were continuously insured. Following outcomes were measured: prevalence and incidence rates, severity of hyperhidrosis and inpatient and outpatient care by a group of specialists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2020, 0.70% of insured adults were confirmed to have HH (mean age 59.5 years, SD 18.9, 61.6% female), with 9.24% having a \u2018localised\u2019 form, 8.65%\u2009a \u2018generalised\u2019 form and 84.80% an \u2018unspecified\u2019 form. 0.04% of the total population had a severe form. The incidence was 0.35%. Localised HH was more common in younger age groups (18 to &lt;30 years), while older age groups (70 to &lt;80 years) were significantly more likely to suffer from generalised HH. Systemic anticholinergics were used in 4.55%, and botulinum toxin injection therapy in 0.81%. General practitioners were most frequently involved in care. Inpatient stays due to HH were very rare, with 0.14% in 2019 and 0.04% in 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multisource data analysis connecting primary and secondary data will be needed for a complete picture of the healthcare and epidemiology of HH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-085862","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T19:05:49Z","timestamp":1723489549000},"page":"e085862","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology and health care of hyperhidrosis in Germany: claims data analysis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-1479","authenticated-orcid":false,"given":"Kristina","family":"Hagenstr\u00f6m","sequence":"first","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frenz","family":"Ohm","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"2025120520053406000_14.8.e085862.1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jaad.2010.03.013","article-title":"Clinical differentiation of primary from secondary hyperhidrosis","volume":"64","author":"Walling","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"2025120520053406000_14.8.e085862.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06334.x"},{"key":"2025120520053406000_14.8.e085862.3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10286-023-00954-w","article-title":"Quality of life in individuals with primary hyperhidrosis: a systematic review and meta-analysis","volume":"33","author":"Henning","year":"2023","journal-title":"Clin Auton Res"},{"key":"2025120520053406000_14.8.e085862.4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bjd\/ljac010","article-title":"Burden of disease: assessing quality-of-life impacts in hyperhidrosis","volume":"188","author":"Gabes","year":"2023","journal-title":"Br J Dermatol"},{"key":"2025120520053406000_14.8.e085862.5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000351292","article-title":"Prevalence and disease burden of hyperhidrosis in the adult population","volume":"227","author":"Augustin","year":"2013","journal-title":"Dermatology"},{"key":"2025120520053406000_14.8.e085862.6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jaad.2017.10.004","article-title":"Epidemiology of hyperhidrosis in 2 population-based health care databases","volume":"78","author":"Ricchetti-Masterson","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2025120520053406000_14.8.e085862.7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.det.2014.06.006","article-title":"Incidence and prevalence of hyperhidrosis","volume":"32","author":"Moraites","year":"2014","journal-title":"Dermatol Clin"},{"key":"2025120520053406000_14.8.e085862.8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00403-016-1697-9","article-title":"Hyperhidrosis: an update on prevalence and severity in the United States","volume":"308","author":"Doolittle","year":"2016","journal-title":"Arch Dermatol Res"},{"key":"2025120520053406000_14.8.e085862.9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/s1806-37562017000000379","article-title":"Hyperhidrosis: prevalence and impact on quality of life","volume":"44","author":"Hasimoto","year":"2018","journal-title":"J Bras Pneumol"},{"key":"2025120520053406000_14.8.e085862.10","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3790","article-title":"Epidemiology of hyperhidrosis in Danish blood donors","volume":"101","author":"Henning","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"2025120520053406000_14.8.e085862.11","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1159\/000448032","article-title":"Prevalence and characteristics of hyperhidrosis in Sweden: a cross-sectional study in the general population","volume":"232","author":"Shayesteh","year":"2016","journal-title":"Dermatology"},{"key":"2025120520053406000_14.8.e085862.12","unstructured":"Gesundheitsberichterstattung des Bundes (BGE-Bund) . KM 6-statistik 2020. Available: https:\/\/www.gbe-bund.de\/gbe\/ergebnisse.prc_tab?fid=9156&suchstring=&query_id=&sprache=D&fund_typ=DQ&methode=&vt=&verwandte=1&page_ret=0&seite=1&p_lfd_nr=15&p_news=&p_sprachkz=D&p_uid=gast&p_aid=89852232&hlp_nr=2&p_janein=J [Accessed 02 Sep 2023]."},{"key":"2025120520053406000_14.8.e085862.13","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(17)31280-1","article-title":"Statutory health insurance in Germany: a health system shaped by 135 years of solidarity, self-governance, and competition","volume":"390","author":"Busse","year":"2017","journal-title":"Lancet"},{"key":"2025120520053406000_14.8.e085862.14","unstructured":"Federal agency for cartography and geodesy: dataset of administrative areas, shape format. 2020. Available: https:\/\/gdz.bkg.bund.de\/index.php\/default\/verwaltungsgebiete-1-2-500-000-stand-31-12-vg2500-12-31.html [Accessed 14 Jan 2021]."},{"key":"2025120520053406000_14.8.e085862.15","unstructured":"Rzany B , Bechara F , Feise K , et al . Aktualisierung der S1-leitlinie zur definition und therapie der prim\u00e4ren hyperhidrose. Available: https:\/\/register.awmf.org\/de\/Leitlinien\/detail\/013-059l [Accessed 20 Jun 2024]."},{"key":"2025120520053406000_14.8.e085862.16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.36849\/JDD.2020.5162","article-title":"Diagnosis and management of primary hyperhidrosis: practical guidance and current therapy update","volume":"19","author":"Gorelick","year":"2020","journal-title":"J Drugs Dermatol"},{"key":"2025120520053406000_14.8.e085862.17","doi-asserted-by":"crossref","first-page":"676","DOI":"10.4103\/idoj.IDOJ_55_19","article-title":"Hyperhidrosis prevalence: a disease underreported by patients and underdiagnosed by physicians","volume":"10","author":"Wadhawa","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"2025120520053406000_14.8.e085862.18","unstructured":"Statistisches Bundesamt . 13 % weniger station\u00e4re Krankenhausbehandlungen im Jahr 2020. Available: https:\/\/www.destatis.de\/DE\/Presse\/Pressemitteilungen\/2021\/09\/PD21_445_231.html [Accessed 16 Oct 2022]."},{"key":"2025120520053406000_14.8.e085862.19","unstructured":"GENESIS Online . Federal statistical office of Germany. Available: https:\/\/www-genesis.destatis.de\/genesis\/online [Accessed 09 Oct 2023]."},{"key":"2025120520053406000_14.8.e085862.20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2147\/CLEP.S315888","article-title":"Prevalence and medications of atopic dermatitis in Germany: claims data analysis","volume":"13","author":"Hagenstr\u00f6m","year":"2021","journal-title":"Clin Epidemiol"},{"key":"2025120520053406000_14.8.e085862.21","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmv056"},{"key":"2025120520053406000_14.8.e085862.22","unstructured":"Schubert I , Ihle P , K\u00f6ster I . Verwendung von GKV-Diagnosen in der Sekund\u00e4rdatenfoschung. In: Swart E , Ihle P , eds. Routinedaten im Gesundheitswesen Handbuch Sekund\u00e4rdatenanalyse: Grundlagen, Methoden und Perspektiven. Bern: Hans-Huber, 2006: 235\u201352."},{"key":"2025120520053406000_14.8.e085862.23","doi-asserted-by":"crossref","unstructured":"Swart E . Health care utilization research using secondary data. In: Janssen C , Ladebeck N , von T , eds. Health Care Utilization in Germany: Theory, Methodology, and Results. Springer, 2014: 63\u201386.","DOI":"10.1007\/978-1-4614-9191-0_5"},{"key":"2025120520053406000_14.8.e085862.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03305.x"},{"key":"2025120520053406000_14.8.e085862.25","first-page":"45","article-title":"Prevalence of psoriasis and psoriatic arthritis in Germany - analysis of claims data","volume":"22","author":"Hagenstr\u00f6m","year":"2024","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-085862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:05:47Z","timestamp":1764993947000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-085862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,12]]},"published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1136\/bmjopen-2024-085862"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-085862","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}