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Logistic regression revealed that those with children at home, larger social circles, and pain, depression or trauma had higher odds, but older individuals and women had lower odds (p&lt;0.05) of drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mobility restriction was a risk factor for drug use. Demographics and mental health conditions were important covariates, underscoring the need for further research on unintended consequences of infection control policies during national health crises.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086141","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T18:40:27Z","timestamp":1741372827000},"page":"e086141","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Representative national survey on drug use during the COVID-19 stay-at-home order in the USA"],"prefix":"10.1136","volume":"15","author":[{"given":"Soo-Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Athey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-2385","authenticated-orcid":false,"given":"Calliope","family":"Holingue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nestadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Vannorsdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1366-1604","authenticated-orcid":false,"given":"Phillip","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"2025040100161311000_15.3.e086141.1","unstructured":"Centers for disease, control and prevention . 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