{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:44:17Z","timestamp":1792194257955,"version":"4.4.0"},"reference-count":22,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,7,9]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"\n Introduction<\/jats:title>\n The dynamic arterial elastance (EaDyn), calculated as pulse pressure variation divided by stroke volume variation, has been studied as a predictor of vasopressor weaning. However, its potential as a haemodynamic tool for tapering off vasopressors in patients with sepsis remains unexplored. Therefore, our study aimed to assess whether using EaDyn for weaning vasopressor support could reduce the duration of vasopressor support in patients with sepsis.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n This pragmatic single-centre controlled clinical trial will take place at Fundaci\u00f3n Santa Fe de Bogot\u00e1, Colombia. Adult patients diagnosed with septic shock according to the sepsis-3 criteria and a Sequential Organ Failure Assessment score \u22654\u2009will be included. A total of 114 patients (57 per group) will undergo conventional critical care monitoring, and the weaning of vasopressor support will be initiated based on the EaDyn or mean arterial pressure (MAP), depending on the assigned group. EaDyn will be estimated based on the measurements obtained from a PiCCO device connected to a PulsioFlex Monitoring Platform (PULSION Medical Systems SE, Feldkirchen, Germany). Our primary outcome is the difference in vasopressor support duration between the EaDyn and MAP groups.<\/jats:p>\n Participants and statisticians performing the statistical analysis will be blinded to the group allocation. Dependent and independent variables will be analysed through univariate and multivariate statistical tests. Since we will perform three repeated measurements for analysis, we will implement a Bonferroni post hoc correction. Additionally, Cox regression and Kaplan-Meier analyses will be conducted to address objectives related to time.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n This study was approved by the Ethics Committee at Fundaci\u00f3n Santa Fe de Bogot\u00e1 (CCEI-16026-2024). Written informed consent will be obtained from all participants. The results will be disseminated through publication in peer-reviewed journals and presentations at national and international events.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n \n NCT06118775<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086388","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:52:01Z","timestamp":1723089121000},"page":"e086388","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of dynamic arterial elastance for weaning vasopressor support in septic shock patients: a randomised controlled trial protocol"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct06118775","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06118775","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-3150","authenticated-orcid":false,"given":"Jorge Iv\u00e1n","family":"Alvarado S\u00e1nchez","sequence":"first","affiliation":[{"name":"Critical Care Unit, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"},{"name":"Department of Physiology Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Valentina","family":"Monta\u00f1ez-Nari\u00f1o","sequence":"additional","affiliation":[{"name":"Critical Care Unit, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenny Rocio","family":"C\u00e1rdenas-Bolivar","sequence":"additional","affiliation":[{"name":"Critical Care Unit, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Valentina","family":"Stozitzky-R\u00edos","sequence":"additional","affiliation":[{"name":"Critical Care Unit, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-0080","authenticated-orcid":false,"given":"Andr\u00e9s Felipe","family":"Mora-Salamanca","sequence":"additional","affiliation":[{"name":"Critical Care Unit, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, 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