{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:55:26Z","timestamp":1785390926006,"version":"3.55.0"},"reference-count":44,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["201369"],"award-info":[{"award-number":["201369"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,8,29]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Between January 1986 and December 2022, a total of 1446 mother\u2013child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings to date<\/jats:title>\n                  <jats:p>During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Future plans<\/jats:title>\n                  <jats:p>Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or <jats:italic>Treponema pallidum<\/jats:italic>. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086543","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T08:30:30Z","timestamp":1727080230000},"page":"e086543","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)"],"prefix":"10.1136","volume":"14","author":[{"given":"Paolo","family":"Paioni","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Children\u2019s Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murezi","family":"Capaul","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Brunner","sequence":"additional","affiliation":[{"name":"Frauenklinik, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Traytel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland"},{"name":"Institute of Medical Virology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Aebi-Popp","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department of Obstetrics and Gynecology, Lindenhofspital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alex","family":"Crisinel","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Infectious Diseases and Vaccinology, Department of Woman Mother and Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Duppenthaler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huldrych","family":"G\u00fcnthard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Begona","family":"Martinez De Tejada","sequence":"additional","affiliation":[{"name":"Obstetrics Division. Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kottanattu","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics of Southern Switzerland, EOC, Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"St\u00f6ckle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemie","family":"Wagner","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Unit, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"H\u00f6sli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Rudin","sequence":"additional","affiliation":[{"name":"University Children's Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Scherrer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kusejko","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-3276","authenticated-orcid":false,"given":"Christian R","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Cantonal Hospital St. Gallen, Department of Infectious Diseases, Infection Prevention and Travel Medicine, St Gallen, Switzerland"},{"name":"Children\u2019s Hospital of Eastern Switzerland, Infectious Diseases and Hospital Epidemiology, St Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"2025101813593314000_14.9.e086543.1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp321"},{"key":"2025101813593314000_14.9.e086543.2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab141"},{"key":"2025101813593314000_14.9.e086543.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959360"},{"key":"2025101813593314000_14.9.e086543.4","first-page":"2322","article-title":"HIV and pregnancy","volume":"125","author":"Rudin","year":"1995","journal-title":"Schweiz Med Wochenschr"},{"key":"2025101813593314000_14.9.e086543.5","doi-asserted-by":"crossref","DOI":"10.2196\/44567","article-title":"Migrating a Well-Established Longitudinal Cohort Database From Oracle SQL to Research Electronic Data Entry (REDCap): data Management Research and Design Study","volume":"7","author":"Kusejko","year":"2023","journal-title":"JMIR Form Res"},{"key":"2025101813593314000_14.9.e086543.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"key":"2025101813593314000_14.9.e086543.7","first-page":"746","volume-title":"Zidovudin Zur Prophylaxe Der HIV-Uebertragung von Der Infizierten Mutter Auf Ihr Kind","volume":"43","year":"1994"},{"key":"2025101813593314000_14.9.e086543.8","unstructured":"Kind C , Rudin C , Siegrist CA , et al . 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