{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:09:34Z","timestamp":1773896974276,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ume\u00e5 University and University Hospital"},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Swedish Heart Lung Foundation","award":["20200485"],"award-info":[{"award-number":["20200485"]}]},{"name":"Lund and Sk\u00e5ne University Hospital"},{"DOI":"10.13039\/501100014196","name":"Sahlgrenska University Hospitals Research Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6ping University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stockholm County council"},{"name":"the University of Gothenburg"},{"name":"Link\u00f6ping University Hospital"},{"name":"the Knut and Alice Wallenberg Foundation"},{"name":"Uppsala University and University Hospital"},{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,10,14]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"Obstructive sleep apnoea (OSA) and its associations with lung function.<\/jats:p>\n \n Background<\/jats:title>\n OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50\u201364 years.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n The population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Ume\u00e5 and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as \u00df-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Data from<\/jats:named-content>\n 9016\n participants (<\/jats:named-content>\n 54%\n women, age<\/jats:named-content>\n 58\u00b14 years\n , body mass index<\/jats:named-content>\n 27\u00b14\u2009kg\/m\n 2<\/jats:sup>\n ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during<\/jats:named-content>\n 1\u2009s\n (FEV<\/jats:named-content>\n 1<\/jats:sub>\n ) (<\/jats:named-content>\n \u00df=\u22120.10 (95% CI \u22120.16 to \u22120.03)\n ),<\/jats:named-content>\n forced vital capacity\n (<\/jats:named-content>\n FVC\n ) (<\/jats:named-content>\n \u22120.15 (\u22120.21 to \u22120.10)\n ) and<\/jats:named-content>\n diffusion capacity for carbon monoxide\n (<\/jats:named-content>\n DL\n CO<\/jats:sub>\n ) (<\/jats:named-content>\n \u22120.08 (\u22120.10 to \u22120.05)\n ) were all negatively associated with the<\/jats:named-content>\n oxygen desaturation index\n (ODI) and also with per cent of registration with nocturnal oxygen saturation<\/jats:named-content>\n <90%\u2009FVC\n (<\/jats:named-content>\n \u22120.44 (\u22120.87 to \u22120.01)\n ), FEV<\/jats:named-content>\n 1<\/jats:sub>\n (<\/jats:named-content>\n \u22120.86 (\u22121.36 to \u22120.36\n )) and DL<\/jats:named-content>\n CO<\/jats:sub>\n (<\/jats:named-content>\n \u22120.47 (\u22120.60 to \u22120.35)\n ). Additionally, a positive association was observed between FEV<\/jats:named-content>\n 1<\/jats:sub>\n (<\/jats:named-content>\n 0.13 (0.05 to 0.22)\n ) and DL<\/jats:named-content>\n CO<\/jats:sub>\n (<\/jats:named-content>\n 0.07 (0.04 to 0.09)\n ) with the mean nocturnal saturation. There was a negative association between DL<\/jats:named-content>\n CO<\/jats:sub>\n and<\/jats:named-content>\n apnoea-hypopnoea index\n , AHI, (<\/jats:named-content>\n \u00df=\u22120.04 (95% CI\u22120.06 to \u22120.03)\n ), while no associations were found between FEV<\/jats:named-content>\n 1<\/jats:sub>\n or FVC and AHI.<\/jats:named-content>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In OSA, lower lung function is more distinctly associated with the nocturnal hypoxic burden than AHI. Potential lung function impairment should be investigated in OSA patients with a high ODI relative to AHI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086596","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T21:55:55Z","timestamp":1731880555000},"page":"e086596","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) \u2013 a cross-sectional study"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2404-4380","authenticated-orcid":false,"given":"Baz","family":"Delshad","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, 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