{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:45:36Z","timestamp":1767840336835,"version":"3.49.0"},"reference-count":61,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,10,16]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Due to prognostic uncertainty and limited decision-making capacity, the choice to perform transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS) and comorbid dementia is challenging. This study explores older adults\u2019 perspectives on complex decision-making preceding TAVI in the hypothetical setting of comorbid dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Qualitative study entailing semistructured interviews. Analysis was by systematic text condensation. The interview guide addressed their attitudes regarding treatment dilemmas before TAVI in patients living with dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Patients were recruited from the TAVI outpatient clinic at a university hospital performing TAVI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A purposive sample of 10 older adults (5\u2009women) with AS and without dementia (range 77\u201394 years), where 8\/10 had undergone TAVI were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Three main challenges were identified: (1) Risk assessment. Participants found it hard to compare the burden of aortic stenosis vs dementia. They acknowledged the dilemma of implanting a new heart valve to achieve symptom relief while risking severe dementia in the future due to prolonged life span. (2) Autonomous capacity. A profound uncertainty was described regarding who should participate in decision-making if the person was incapacitated due to dementia. (3) Customised information. Participants advocated for thorough information describing facts and uncertainty, aiming to protect and support the person living with dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Older adults with severe aortic stenosis find it hard relating to dilemmas arising from providing TAVI in patients living with dementia. There is a need for tailor-made information to support autonomy and decision-making under uncertainty.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086674","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T13:16:02Z","timestamp":1731417362000},"page":"e086674","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["\u2018If you\u2019ve lost your personality, there\u2019s no point in changing the valve\u2019\u2014a qualitative study of older adults\u2019 attitudes towards treatment of aortic stenosis with comorbid dementia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-884X","authenticated-orcid":false,"given":"Elisabeth","family":"Skaar","sequence":"first","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri","family":"Rostoft","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo Faculty of Medicine, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Cruz-Jentoft","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Ram\u00f3n y Caja, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-8707","authenticated-orcid":false,"given":"\u00d8yvind","family":"Bleie","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-066X","authenticated-orcid":false,"given":"Erik","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"\u00d8ksnes","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margrethe Aase","family":"Schaufel","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Vestland, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"2025101813133764000_14.11.e086674.1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302265"},{"key":"2025101813133764000_14.11.e086674.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"2025101813133764000_14.11.e086674.3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/oxfordjournals.eurheartj.a062307","article-title":"Spontaneous course of aortic valve disease","volume":"8","author":"Turina","year":"1987","journal-title":"Eur Heart J"},{"key":"2025101813133764000_14.11.e086674.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"2025101813133764000_14.11.e086674.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"2025101813133764000_14.11.e086674.6","unstructured":"Hovland S , Sk\u00e5re K , Autenried M , et al . 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