{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:47:08Z","timestamp":1765892828094,"version":"3.48.0"},"reference-count":37,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,9,13]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cachexia is strongly associated with digestive cancers, particularly oesogastric cancer. Mitochondria in adipose tissue are involved in the regulation of metabolism and physiopathology of cancer cachexia in animal studies. Chemotherapeutic regimens used to control tumour development could also alter mitochondrial function in adipose tissue. We hypothesise that cachexia induces an increase in adipose tissue mitochondrial energy metabolism and that chemotherapy can mitigate this. The purpose of the ChiFMeOE study is to identify adipocyte factors involved in the energy imbalance associated with the cachectic process and their response to chemotherapeutic treatments in patients with oesogastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>ChiFMeOE is a single-centre observational study that will prospectively include 60 patients referred to chemotherapy and surgery for oesophageal and gastro-oesophageal junction adenocarcinomas at the University Hospital of Clermont-Ferrand, France. Visceral and subcutaneous adipose tissue biopsies will be collected during surgery scheduled before and after neoadjuvant chemotherapy administration, as well as cachexia and nutritional assessment. The primary outcome is the maximum mitochondrial respiration rate (Vmax) measured by high-resolution respirometry. Secondary outcomes are other mitochondrial parameters (ie, enzymatic activities, proteins content and gene expression), tumour characteristics, nutritional status and body composition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was approved by an independent institutional review board on June 2023 (Comit\u00e9 de protection des personnes Sud-M\u00e9diterran\u00e9e V; 2023-A00582-43) and declared to the French regulatory authority for research. Written informed consent will be obtained prior to patient inclusion. The principal investigator will be notified of any changes in patient\u2019s health status requiring a modification of his management and\/or treatment during the course of the protocol. Results will be published in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\" xlink:href=\"NCT05954117\">NCT05954117<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-086686","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T02:00:27Z","timestamp":1729735227000},"page":"e086686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Chemotherapy effects on mitochondrial function in adipose tissue in oesophageal and gastroesophageal junction adenocarcinomas with or without associated cachexia: protocol for a prospective, comparative observational study (ChiFMeOE)"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05954117","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct05954117","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05954117","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4352-5854","authenticated-orcid":false,"given":"Oph\u00e9lie","family":"Bacoeur-Ouzillou","sequence":"first","affiliation":[{"name":"Digestive and Hepatobiliary Surgery department, CHU Clermont-Ferrand, Clermont-Ferrand, France"},{"name":"INRAe, Unit\u00e9 de Nutrition Humaine, ASMS team, F-63000 Clermont-Ferrand, France, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Guerrier","sequence":"additional","affiliation":[{"name":"INRAe, Unit\u00e9 de Nutrition Humaine, ASMS team, F-63000 Clermont-Ferrand, France, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne","family":"Touron","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Nutrition Humaine, Clermont-Ferrand, France"},{"name":"D.REF-AERO, Unit\u00e9 Fatigue et Vigilance, IRBA, Bretigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Pinel","sequence":"additional","affiliation":[{"name":"INRAe, Unit\u00e9 de Nutrition Humaine, ASMS team, F-63000 Clermont-Ferrand, France, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biostatistics unit, CHU Clermont-Ferrand, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Meunier","sequence":"additional","affiliation":[{"name":"Nutrition Exploration Unit (UEN) - 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