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Clinical research is needed to investigate adequate dosage of physical rehabilitation and its effects on outcomes with reliable and validated outcome measurements. In this study we will investigate the feasibility of a highly intensive physical rehabilitation intervention and outcomes with reliable and valid outcome measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Our study with a prospective case-series design will evaluate (1) The safety and feasibility of a high-intensive physical rehabilitation programme to improve functioning and participation in children and adolescents with ABI, and (2) The feasibility of a core set of clinical outcome measures to assess recovery on relevant International Classification of Functioning, Disability, and Health domains during the subacute phase. We aim to include 10\u201315 children and adolescents aged 6\u201320 years with moderate-severe ABI during subacute rehabilitation in a specialised youth department for inpatient rehabilitation in The Netherlands. In the rehabilitation programme, we aim at a highly intensive approach of 3\u20135\u2009hours physical rehabilitation per day during inpatient rehabilitation. Frequent and systematic assessment (baseline, each consecutive 6 weeks -if applicable- and at discharge) through a core set of outcome measures will provide insights into the degree of recovery of motor and cognitive functioning. We use descriptive and inferential statistics and thematic content analysis for analysis of the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study has been approved by the Medical Ethics Research Committee of the University Medical Hospital, Utrecht (reference number: 23U-0628). We aim to disseminate our findings in peer-reviewed journals and present at national and international conferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-087768","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T21:36:45Z","timestamp":1737409005000},"page":"e087768","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["High-intensive physical rehabilitation approach in children and adolescents with acquired brain injury during subacute phase (REHABILITY): a feasibility study protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-3758","authenticated-orcid":false,"given":"Christiaan","family":"Gmelig Meyling","sequence":"first","affiliation":[{"name":"UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands"},{"name":"Department of Pediatric Rehabilitation, De Hoogstraat Rehabilitation, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Verschuren","sequence":"additional","affiliation":[{"name":"UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Rentinck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Psychology, UMC Utrecht - Locatie WKZ, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"van der Steen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rehabilitation, De Hoogstraat Rehabilitation, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Engelbert","sequence":"additional","affiliation":[{"name":"Department for Rehabilitation, Amsterdam UMC Locatie AMC, Amsterdam, Noord-Holland, The Netherlands"},{"name":"Faculty of Health, Centre of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Gorter","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands"},{"name":"Department of Pediatrics, CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"2025121511021781000_15.1.e087768.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2009.00949.x"},{"key":"2025121511021781000_15.1.e087768.2","first-page":"213","article-title":"Role of the physical and rehabilitation medicine specialist regarding of children and adolescents with acquired brain injury","volume":"49","author":"Varela-Donoso","year":"2013","journal-title":"Eur J Phys Rehabil Med"},{"key":"2025121511021781000_15.1.e087768.3","unstructured":"WHO . 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