{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:02:08Z","timestamp":1793070128169,"version":"4.5.0"},"reference-count":33,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,7,31]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many cancer treatments pose a threat to fertility for patients. Semen cryopreservation before cancer treatment is an effective method to preserve fertility. There are sparse long-term data on the usage of samples from Canadian oncology sperm banks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of all oncology sperm banking samples at a Canadian academic fertility centre from 2001 to 2020 was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2001 to 2020, 4521 samples were banked by 2504 patients. The most frequent diagnoses among these patients were testicular cancer (29.5%) and lymphoma (26.9%). Of these patients, only 81 (3.2%) patients returned to use their samples with intrauterine insemination (IUI) or in vitro fertilisation (IVF) treatment and 62 (2.5%) patients transferred their samples to another clinic. The time between banking and return for usage of the sperm ranged from 1 to 131 months with a median of 18 months after banking. A total of 66 IVF cycles (104 embryo transfers) and 101 IUI cycles from 67 patients were reviewed. Of the 67 couples who used their samples, 53.7% achieved a clinical pregnancy. The clinical pregnancy rate was 6.6% per cycle for IUI and 30.8% per embryo transfer for IVF. Higher sperm concentration or total motile count was not associated with a higher chance of pregnancy. Patients who conceived had on average 1.9\n\u00b1\n0.8 (p=0.02) more usable embryos per cycle than those who did not conceive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sperm cryopreservation provides a valuable option for patients with cancer to achieve parenthood after potentially gonadotoxic cancer treatment. However, the overall usage of banked oncology sperm samples is very low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088112","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T23:15:54Z","timestamp":1723590954000},"page":"e088112","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Twenty-year oncology sperm banking experience at a Canadian academic fertility centre: a retrospective study examining the usage and reproductive outcomes from oncology patients"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-2224","authenticated-orcid":false,"given":"Tianhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"},{"name":"MD Program, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"},{"name":"Mount Sinai Fertility, Sinai Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada"},{"name":"Mount Sinai Fertility, Sinai Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"2025121602235236000_14.8.e088112.1","unstructured":"Canadian cancer statistics advisory in collaboration with the Canadian cancer society, statistics Canada and the public health agency of Canada. Canadian cancer statistics: a 2022 special report on cancer prevalence. Toronto, ON Canadian Cancer Society; 2022. 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WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th Ed. Cambridge: Cambridge University Press, 1999."},{"key":"2025121602235236000_14.8.e088112.14","unstructured":"World Health Organization . WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th Ed. 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