{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:40:27Z","timestamp":1765082427479,"version":"3.46.0"},"reference-count":28,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trial Network","award":["Practitioner Fellowship"],"award-info":[{"award-number":["Practitioner Fellowship"]}]},{"DOI":"10.13039\/100009727","name":"The Hospital Research Foundation Group","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian National Health and Medical Research Council","award":["Investigator Fellowship \/ APP1194483"],"award-info":[{"award-number":["Investigator Fellowship \/ APP1194483"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,11,27]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The pharmacological management of inflammatory arthritis often requires choices that involve trade-offs between benefits, risks and other attributes such as administration route, frequency and cost. This living systematic review aims to inform international clinical guidelines on inflammatory arthritis by creating an evidence map of patient preference studies concerning the trade-offs in pharmacological management of inflammatory arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will include published and peer-reviewed full-text studies in any language that quantitatively assess preferences of patients for the pharmacological management of inflammatory arthritis (rheumatoid arthritis, spondyloarthritis and juvenile idiopathic arthritis). Studies must use either stated or revealed preference methods to assess preferences and provide a quantitative assessment of relevant characteristics, such as benefits, risks, costs and process attributes. Articles will identified through Medline and EMBASE database searches from inception using search terms that combine keywords and subject headings for inflammatory arthritis and preference-based methods, and a search in the Health Preference Study and Technology Registry using keywords for the populations of interest. Two independent reviewers will perform abstract and full-text screening. Risk of bias will be assessed using the GRADE risk of bias tool. An evidence map will be generated to summarise included studies and their assessments of each trade-off. The search will be conducted every 6 months with new studies added to the inventory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval is not required. Results from the base review will be published in a peer-reviewed journal and findings will be presented at conferences. In the living model, we will publish updates and datasets on an Open Science Framework page, with periodic updates in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088267","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T04:02:08Z","timestamp":1737000128000},"page":"e088267","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Patient preferences for drug therapy in inflammatory arthritis: protocol for a living systematic review and evidence map to inform clinical practice guidelines"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-8962","authenticated-orcid":false,"given":"Pakeezah","family":"Saadat","sequence":"first","affiliation":[{"name":"Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Bansback","sequence":"additional","affiliation":[{"name":"School of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Arthritis Research Canada, Richmond, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-486X","authenticated-orcid":false,"given":"Marie","family":"Falahee","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-9258","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Hiligsmann","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, CAPHRI Care and Public Health research Institute, Maastricht University, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tugwell","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada"},{"name":"Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Musculoskeletal Health and Wiser Health Care Units, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Whittle","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"},{"name":"Rheumatology Unit, Queen Elizabeth Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-0826","authenticated-orcid":false,"given":"Dawn P","family":"Richards","sequence":"additional","affiliation":[{"name":"Canadian Arthritis Patient Alliance, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Proulx","sequence":"additional","affiliation":[{"name":"Canadian Arthritis Patient Alliance, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schunemann","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Biomedical Sciences, Humanitas University, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-8504","authenticated-orcid":false,"given":"Pablo","family":"Alonso-Coello","sequence":"additional","affiliation":[{"name":"Centro GRADE Barcelona, Instituto de Investigacion Biomedica, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robby","family":"Nieuwlaat","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Michael G. DeGroote Cochrane Canada & McMaster GRADE Centres, McMaster University, Hamilton, Ontario, Canada"},{"name":"World Health Organization Collaborating Center for Infectious Diseases, Research Methods and Recommendations, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojtek","family":"Wiercioch","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Michael G. DeGroote Cochrane Canada & McMaster GRADE Centres, McMaster University, Hamilton, Ontario, Canada"},{"name":"World Health Organization Collaborating Center for Infectious Diseases, Research Methods and Recommendations, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Kuper","sequence":"additional","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Limburg, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Pardo Pardo","sequence":"additional","affiliation":[{"name":"Cochrane Musculoskeletal, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-3741","authenticated-orcid":false,"given":"Glen","family":"Hazlewood","sequence":"additional","affiliation":[{"name":"Arthritis Research Canada, Richmond, British Columbia, Canada"},{"name":"Departments of Medicine and Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada"},{"name":"McCaig Institute for Bone and Joint Health, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"2025120619024862000_15.1.e088267.1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i1777","article-title":"Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis","volume":"353","author":"Hazlewood","year":"2016","journal-title":"BMJ"},{"key":"2025120619024862000_15.1.e088267.2","article-title":"Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis","volume":"2016","author":"Hazlewood","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2025120619024862000_15.1.e088267.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109927"},{"key":"2025120619024862000_15.1.e088267.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00798-0"},{"key":"2025120619024862000_15.1.e088267.5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/art.40726","article-title":"Special Article: 2018 American College of Rheumatology\/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis","volume":"71","author":"Singh","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2025120619024862000_15.1.e088267.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.09.011"},{"key":"2025120619024862000_15.1.e088267.7","first-page":"215","article-title":"Qualitative approaches to understanding patient preferences","volume":"5","author":"Gooberman-Hill","year":"2012","journal-title":"Patient"},{"key":"2025120619024862000_15.1.e088267.8","unstructured":"Medical device innovation consortium . Medical device innovation consortium (mdic) patient centered benefit-risk project report: a framework for incorporating information on patient preferences regarding benefit and risk into regulatory assessments of new medical technology. 2015. Available: https:\/\/mdic.org\/project\/patient-centered-benefit-risk-pcbr\/ [Accessed Sep 2023]."},{"key":"2025120619024862000_15.1.e088267.9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.rdc.2018.01.009","article-title":"Measuring Patient Preferences: An Overview of Methods with a Focus on Discrete Choice Experiments","volume":"44","author":"Hazlewood","year":"2018","journal-title":"Rheum Dis Clin North Am"},{"key":"2025120619024862000_15.1.e088267.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.05.001"},{"key":"2025120619024862000_15.1.e088267.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281422"},{"key":"2025120619024862000_15.1.e088267.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.02.003"},{"key":"2025120619024862000_15.1.e088267.13","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.220209"},{"key":"2025120619024862000_15.1.e088267.14","unstructured":"Hazlewood GS , Pardo JP , Barnabe C , et al . Canadian rheumatology association living guidelines for the pharmacological management of rheumatoid arthritis with disease-modifying anti-rheumatic drugs 2022. Available: https:\/\/app.magicapp.org\/#\/guideline\/7554 [Accessed 31 May 2024]."},{"key":"2025120619024862000_15.1.e088267.15","unstructured":"Australia & New Zealand Musculoskeletal Clinical Trials Network (ANZMUSC) . An australian living guideline for the pharmacological management of inflammatory arthritis. 2023 Available: https:\/\/app.magicapp.org\/#\/guideline\/LqRV3n"},{"key":"2025120619024862000_15.1.e088267.16","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/imj.16073","article-title":"Australian recommendations on perioperative use of disease-modifying anti-rheumatic drugs in people with inflammatory arthritis undergoing elective surgery","volume":"53","author":"Buchbinder","year":"2023","journal-title":"Int Med J"},{"key":"2025120619024862000_15.1.e088267.17","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1111\/imj.15816","article-title":"Australian recommendations on tapering of biologic and targeted synthetic disease-modifying anti-rheumatic drugs in inflammatory arthritis","volume":"52","author":"Whittle","year":"2022","journal-title":"Intern Med J"},{"key":"2025120619024862000_15.1.e088267.18","doi-asserted-by":"publisher","DOI":"10.7326\/M22-0514"},{"key":"2025120619024862000_15.1.e088267.19","doi-asserted-by":"crossref","unstructured":"Hazlewood GS , Whittle SL , Kamso MM , et al . Disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a systematic review and network meta-analysis. Cochrane Database Syst Rev 2020. doi:10.1002\/14651858.CD013562","DOI":"10.1002\/14651858.CD013562"},{"key":"2025120619024862000_15.1.e088267.20","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02707-4","article-title":"Systematic review of quantitative preference studies of treatments for rheumatoid arthritis among patients and at-risk populations","volume":"24","author":"Simons","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"2025120619024862000_15.1.e088267.21","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181165"},{"key":"2025120619024862000_15.1.e088267.22","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"2025120619024862000_15.1.e088267.23","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2527"},{"key":"2025120619024862000_15.1.e088267.24","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-017-0698-5","article-title":"Development and use of a content search strategy for retrieving studies on patients\u2019 views and preferences","volume":"15","author":"Selva","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"2025120619024862000_15.1.e088267.25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jclinepi.2022.03.019","article-title":"Crowdsourcing trainees in a living systematic review provided valuable experiential learning opportunities: a mixed-methods study","volume":"147","author":"Lee","year":"2022","journal-title":"J Clin Epidemiol"},{"key":"2025120619024862000_15.1.e088267.26","first-page":"1083","article-title":"Supporting Equity Through Rheumatoid Arthritis Treatment Guidelines: The Development of Logic Models for Six Populations at Risk for Inequitable Outcomes in Canada","volume":"47","author":"Pianarosa","year":"2020","journal-title":"J Rheumatol"},{"key":"2025120619024862000_15.1.e088267.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.06.013"},{"key":"2025120619024862000_15.1.e088267.28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/acr.25278","article-title":"Rheumatoid Arthritis Care Experiences of Black People Living in Canada: A Qualitative Study to Inform Health Service Improvements","volume":"76","author":"Thomas","year":"2023","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-088267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:03:01Z","timestamp":1765076581000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-088267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,15]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/bmjopen-2024-088267"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-088267","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}