{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T08:06:00Z","timestamp":1765872360132,"version":"3.48.0"},"reference-count":22,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["RTF23jul-0010"],"award-info":[{"award-number":["RTF23jul-0010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,1,11]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inhalers are critical in asthma treatment, and inappropriate inhaler use leads to poor asthma outcomes. In adults and adolescents, dry powder inhalers (DPIs) are safe and effective alternatives to mainstay pressurised metered dose inhalers and could bridge the asthma care gap while also reducing the environmental burden of asthma care. Despite being licensed for use in ages 5 years old and older, the evidence for clinical effectiveness is less clear for patients between ages 5 and 12 years. This protocol describes a scoping review. The primary aim of the review is to identify and synthesise evidence on the clinical effectiveness of DPI use in children aged 5\u201312 years old with asthma and other wheezing conditions. The secondary aim of the review is to outline the implementation strategies and outcomes supporting the prescribing or switching to DPIs in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will conduct a systematic and comprehensive literature search across four electronic databases (Medline, Embase, Cochrane Library and CINAHL) and grey literature. Screening and data extraction will be done independently by two review authors with discrepancies resolved through consensus. Data will be extracted and charted by two independent reviewers, then presented diagrammatically or tabulated with an accompanying narrative summary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval was not required for this study as it is a scoping review. The results of this scoping review will be submitted to a peer-reviewed scientific journal for publication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088846","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T08:41:32Z","timestamp":1738140092000},"page":"e088846","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical effectiveness and implementation outcomes of pMDI-to-DPI switch in children between 5 and 12 years of age: a scoping review protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-4826","authenticated-orcid":false,"given":"Amanda","family":"Zain","sequence":"first","affiliation":[{"name":"Centre for Sustainable Medicine, National University of Singapore Yong Loo Lin School of Medicine, Singapore"},{"name":"Khoo Teck Puat\u2014National University Children's Medical Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alston Z Y","family":"Ng","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Medicine, National University of Singapore Yong Loo Lin School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-7340","authenticated-orcid":false,"given":"Inez","family":"Yeo","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Medicine, National University of Singapore Yong Loo Lin School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Watts","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Medicine, National University of Singapore Yong Loo Lin School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-8924","authenticated-orcid":false,"given":"Nick","family":"Sevdalis","sequence":"additional","affiliation":[{"name":"Centre for Behavioural and Implementation Science Interventions, National University of Singapore Yong Loo Lin School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"2025121600015174000_15.1.e088846.1","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-023-02475-6","article-title":"Global, regional, and national burden of asthma and its attributable risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"24","author":"Wang","year":"2023","journal-title":"Respir 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