{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:08:26Z","timestamp":1793124506576,"version":"4.5.0"},"reference-count":46,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,12,1]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a prevalent female reproductive and metabolic disorder. Among patients with chronic conditions, an increasing number have approached complementary and alternative medicine (CAM) to cope with their disease. This study aimed to assess the use of CAM among females with PCOS in Jordan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, settings and participants<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted at one of the largest tertiary centres in Jordan. Adult females with PCOS were interviewed using a data collection tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>CAM use and the factors associated with its use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 402\u2009women participated in the study, the median-IQR age was 25 (31\u201321) years. Common PCOS signs\/symptoms included menses irregularity (81.8%), fatigue (71.6%) and hyperandrogenism (77.6%). Among all participants, 63.2% used CAM with the most common being herbs (60.4%). The primary sources of information were family and friends (46.1%).<\/jats:p>\n                    <jats:p>\n                      Longer duration since diagnosis, having more PCOS signs\/symptoms and a higher level of education were factors significantly associated with CAM use (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =1.257, 95% CI=1.018 to 2.552, p=0.034;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =1.146, 95% CI=1.052 to 1.250, p=0.002\u2009and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =1.584, 95% CI=1.054 to 2.379, p=0.027, respectively). Of all the CAM users, 57.5% reported an amelioration in PCOS symptoms; this was significantly associated with the long-term use of CAM (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =12.759, 95% CI=6.789 to 23.976, p&lt;0.001). Just a few participants (9.4%) reported side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A variety of CAM approaches were reported by the study population; herbs were the most widely used and accepted by the patients. Considering the primary source of information and the potential interactions of herbal medicine with the standard PCOS treatment, efforts are needed by healthcare providers to better understand the use of CAM among their patients with PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088945","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T03:08:51Z","timestamp":1735009731000},"page":"e088945","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Use of complementary and alternative medicine among females with polycystic ovary syndrome in Jordan: a cross-sectional study"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-6684","authenticated-orcid":false,"given":"Oriana","family":"Awwad","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics and Clinical Pharmacy, The University of Jordan, Amman, Jordan"},{"name":"University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mais","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-0708","authenticated-orcid":false,"given":"Sanaa K","family":"Bardaweel","sequence":"additional","affiliation":[{"name":"The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alsamydai","sequence":"additional","affiliation":[{"name":"Al-Ahliyya Amman University, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma U","family":"Afifi","sequence":"additional","affiliation":[{"name":"Applied Science Private University, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Akour","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics and Clinical Pharmacy, The University of Jordan, Amman, Jordan"},{"name":"Department of Pharmacology and Therapeutics, United Arab Emirates University, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renad","family":"Abu Tarboosh","sequence":"additional","affiliation":[{"name":"The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Hamdan","sequence":"additional","affiliation":[{"name":"The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma Sa\u2019d","family":"Basha","sequence":"additional","affiliation":[{"name":"The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"2025120618454128000_14.12.e088945.1","article-title":"Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article","volume":"3","author":"Ajmal","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol X"},{"key":"2025120618454128000_14.12.e088945.2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa839"},{"key":"2025120618454128000_14.12.e088945.3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2147\/PPA.S244273","article-title":"Metformin Improves the Depression Symptoms of Women with Polycystic Ovary Syndrome in a Lifestyle Modification Program","volume":"14","author":"AlHussain","year":"2020","journal-title":"Pat Prefer Adherence"},{"key":"2025120618454128000_14.12.e088945.4","unstructured":"Polycystic ovary syndrome. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/polycystic-ovary-syndrome [Accessed 27 Oct 2024]."},{"key":"2025120618454128000_14.12.e088945.5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/ijerph20095717","article-title":"Prevalence of Polycystic Ovary Syndrome amongst Females Aged between 15 and 45 Years at a Major Women\u2019s Hospital in Dubai, United Arab Emirates","volume":"20","author":"Mirza","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"2025120618454128000_14.12.e088945.6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75109-2","article-title":"Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations","volume":"10","author":"Butler","year":"2020","journal-title":"Sci Rep"},{"key":"2025120618454128000_14.12.e088945.7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/09513590.2017.1395841","article-title":"Treatment strategies for women with polycystic ovary syndrome","volume":"34","author":"Jin","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"2025120618454128000_14.12.e088945.8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"2025120618454128000_14.12.e088945.9","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-018-2342-2","article-title":"Complementary and alternative medicine use among persons with multiple chronic conditions: results from the 2012 National Health Interview Survey","volume":"18","author":"Mbizo","year":"2018","journal-title":"BMC Complement Altern Med"},{"key":"2025120618454128000_14.12.e088945.10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joim.2021.11.004","article-title":"Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran","volume":"20","author":"Dehghan","year":"2022","journal-title":"J Integr Med"},{"key":"2025120618454128000_14.12.e088945.11","first-page":"85","article-title":"Polycystic ovaries and herbal remedies: A systematic review","volume":"27","author":"Manouchehri","year":"2023","journal-title":"JBRA Assist Reprod"},{"key":"2025120618454128000_14.12.e088945.12","doi-asserted-by":"crossref","unstructured":"Siddique R , Mehmood MH . 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Essential Herbal Plants for the Clinical Management of Polycystic Ovary Syndrome and Patents for the Same. 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