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Exploring augmentation strategies to enhance treatment outcomes is essential to reduce the overall burden PTSD puts on individuals and society. This protocol outlines a systematic review and meta-analysis of randomised controlled trials (RCTs) evaluating the efficacy of non-pharmacological augmentation strategies in addition to TFP for PTSD treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Analysis<\/jats:title>\n                    <jats:p>We comprehensively searched PubMed, Embase, CENTRAL, PTSDpubs, PsycArticles, PsycINFO, PSYNDEX and CINAHL for RCTs without restrictions on publication dates or languages in October 2024. Study screening is currently ongoing. Additionally, we will perform forward and backward searches of the included studies and relevant reviews. Two reviewers will independently screen and select studies, extract data and assess the risk of bias. We will conduct a narrative review to qualitatively synthesise data and a meta-analysis to quantitatively compare the treatment efficacy of augmented TFP with TFP alone or TFP plus placebo. Primary outcomes will be both symptom severity and response rates. The secondary outcome will be dropout rates. We will explore sources of between-study heterogeneity and potential moderators through subgroup and meta-regression analyses. We will assess the overall quality of the included studies with the Grading of Recommendations Assessment, Development, and Evaluation system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval is not required. We intend to publish results in a peer-reviewed journal and provide materials and data through the Open Science Framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42024549435.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-090571","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:25:28Z","timestamp":1747819528000},"page":"e090571","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Augmentation of trauma-focused psychotherapy for post-traumatic stress disorder: a protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2842-9076","authenticated-orcid":false,"given":"Lisa","family":"Mewes","sequence":"first","affiliation":[{"name":"Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany"},{"name":"PartnerSite Berlin\/Potsdam, Deutsches Zentrum f\u00fcr Psychische Gesundheit, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-956X","authenticated-orcid":false,"given":"Till","family":"Langhammer","sequence":"additional","affiliation":[{"name":"Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5227-6503","authenticated-orcid":false,"given":"Jonathan","family":"Torbecke","sequence":"additional","affiliation":[{"name":"Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-5422","authenticated-orcid":false,"given":"Johannes Caspar","family":"Fendel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-4012","authenticated-orcid":false,"given":"Ulrike","family":"Lueken","sequence":"additional","affiliation":[{"name":"Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany"},{"name":"PartnerSite Berlin\/Potsdam, Deutsches Zentrum f\u00fcr Psychische Gesundheit, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"2025121512263623000_15.5.e090571.1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000167"},{"key":"2025121512263623000_15.5.e090571.2","doi-asserted-by":"crossref","unstructured":"American psychiatric association . 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