{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:04:54Z","timestamp":1768475094468,"version":"3.49.0"},"reference-count":38,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"A. Menarini Asia-Pacific Holdings Pte. Ltd., Singapore","award":["(award\/grant number-N\/A)"],"award-info":[{"award-number":["(award\/grant number-N\/A)"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,9,16]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to determine the usage pattern, effectiveness and safety of oral tramadol 75\u2009mg and dexketoprofen trometamol 25\u2009mg fixed-dose combination (TRAM\/DKP FDC) in the short-term treatment of moderate-to-severe acute pain in real-world clinical practice in Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Real-world, prospective, multicentre, observational, phase IV study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>13 tertiary-care hospital sites across the Philippines, Thailand, Malaysia and Singapore.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Adult patients aged 18\u201380 years prescribed TRAM\/DKP FDC for the short-term (up to 5\u2009days) treatment of moderate-to-severe acute pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Primary endpoints were the proportion of patients prescribed TRAM\/DKP FDC with different types of postsurgical and non-surgical treatments, and the average dosing frequency and duration of TRAM\/DKP FDC treatment. Secondary endpoints were the proportion of patients achieving \u226530%\u2009pain reduction at 8\u2009hours post the first dose (pain severity was assessed using the 11-point Numeric Pain Rating Scale); patient satisfaction at the end of treatment (based on a 5-point Patient Global Evaluation Scale (PGE)) and safety including the incidence of adverse drug reactions (ADRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 599 patients (median age 44 years, 61.3% female) enrolled in this study, 68.61% (n=411) were postsurgical and 31.39% (n=188) were non-surgical patients. TRAM\/DKP FDC was prescribed in a diverse group of postsurgical patients (eg, orthopaedic, general and cancer surgery) as well as in non-surgical conditions (eg, lower back pain and musculoskeletal pain). In the majority of patients, TRAM\/DKP FDC was prescribed every 8\u2009hours (65.94%) and for 5\u2009days (78.80%). There was a significant reduction in pain intensity throughout the study and 65% of patients achieved \u226530%\u2009pain reduction from baseline at 8\u2009hours post the first dose of TRAM\/DKP FDC on day 1. 95.69% of patients were satisfied with the treatment (rated good, very good and excellent on the PGE scale). Overall, 13.9% of patients reported ADRs; most were mild to moderate in severity. The most common ADRs were nausea, vomiting and dizziness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that TRAM\/DKP FDC was used in diverse types of postsurgical and non-surgical patients in the real-world setting in Asia. It effectively reduced pain and was well tolerated with a high level of patient satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-090926","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T20:00:48Z","timestamp":1729195248000},"page":"e090926","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Real-world usage pattern, effectiveness and safety of oral tramadol\/dexketoprofen trometamol fixed-dose combination in moderate-to-severe acute pain in Asia: a prospective, multicentre, observational study"],"prefix":"10.1136","volume":"14","author":[{"given":"Kok Yuen","family":"Ho","sequence":"first","affiliation":[{"name":"The Pain Clinic, Mount Alvernia Hospital, 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