{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:32Z","timestamp":1787320652762,"version":"build-2736575974"},"reference-count":51,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,3,28]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although most cochlear implant (CI) users achieve good speech understanding in quiet without visual cues, they may have limited speech understanding in noise and often have poor music perception. The present study was designed to investigate the degree to which the use of Meludia training can improve music perception, music enjoyment and speech understanding in paediatric and postlingually deafened adult CI users. The study also aims to assess the participants\u2019 changes in cognitive skills (attention and memory) and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This randomised controlled trial will randomise new CI users and experienced CI users older than 6 years who meet the inclusion criteria in a 1:1 ratio to either a musical training (MT) group or a non-MT (NMT) group. The NMT group will receive standard care that does not include MT. Participants in the MT group will practise with Meludia software for 4 weeks and later for 12 additional weeks. Outcomes will include scores in: \u2018Listening Up\u2019 exercises, the -Music-Related Quality of Life questionnaire, the Music Questionnaire for Paediatric Population, Disyllables in silence, Matrix test, Mini Mental State Examination, Performance IQ and the Wechsler intelligence scale for children and the Assessment of Quality of Life\u20148 Dimensions questionnaire. The NMT group will receive standard care that does not include MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>On 16 October 2023, the study protocol was approved by the La Paz Hospital in Madrid (Spain). The findings of this study will be published in peer-reviewed publications and presented at appropriate conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06540677\">NCT06540677<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-092207","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T09:00:53Z","timestamp":1745571653000},"page":"e092207","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Use of Meludia to evaluate the effect of music training in cochlear implant users: study protocol of a randomised controlled study"],"prefix":"10.1136","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct06540677","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06540677","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06540677","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-2185","authenticated-orcid":false,"given":"Miryam","family":"Calvino","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, La Paz University Hospital, Madrid, Spain"},{"name":"IdiPAZ Research Institute, Madrid, Spain"},{"name":"Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gavil\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, La Paz University Hospital, Madrid, Spain"},{"name":"IdiPAZ Research Institute, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Lassaletta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, La Paz University Hospital, Madrid, Spain"},{"name":"IdiPAZ Research Institute, Madrid, Spain"},{"name":"Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"2025081404161297000_15.4.e092207.1","doi-asserted-by":"crossref","unstructured":"Tahmasebi S , Segovia-Martinez M , Nogueira W . 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Cuaderno de logoaudiometr\u00eda: cuadernos de la universidad de educaci\u00f3n a distancia. Simancas Ed; 1994."},{"key":"2025081404161297000_15.4.e092207.39","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2012.670731"},{"key":"2025081404161297000_15.4.e092207.40","first-page":"4","article-title":"Entwicklung und Evaluation eines Satztests in deutscher Sprache - Teil I: Design des Oldenburger Satztests (in German). 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