{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:36:20Z","timestamp":1793676980684,"version":"4.5.1"},"reference-count":29,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Department of Obstetrics and Gynecology, Erasmus University Medical Center"},{"name":"Department of Internal Medicine, Erasmus University Medical Center"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,10,24]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The FUPEC (Follow-Up Pre-EClampsia) study aims to investigate the presence and development of cardiovascular risk factors, cardiovascular disease, as well as cardiovascular health following a pregnancy complicated by severe pre-eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The FUPEC study is an open-cohort study conducted within routine care at the FUPEC clinic at Erasmus Medical Center in the Netherlands. This clinic is specifically designed for the cardiovascular follow-up of patients who have experienced severe pre-eclampsia. Women with a history of severe pre-eclampsia are invited to the FUPEC clinic at 6\u2009weeks, 3\u2009months, 1 year and every 2 years thereafter postpartum until they are 50 years of age. Clinical and biochemical data are routinely collected, encompassing pregnancy characteristics and outcomes, anthropometric measurements, cardiovascular risk factors, cardiovascular health scores, carotid intima-media thickness\u2014including vascular age and ambulatory blood pressure measurements. Additionally, blood and urine samples are collected and stored in a biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>\n                      The first patient was enrolled in April 2011. As of March 2024, a total number of 1268\u2009women have been enrolled in the FUPEC study, with an annual enrolment rate of 100\u2013150 new patients. At inclusion, women had a median age of 33.5 years (IQR 30.1\u201337.9). At their first FUPEC visit, women were a median of 4.9 months (1.9\u201329.4) after delivery. At the first visit, the median body mass index was 25.7 (IQR 23.0\u201329.9)\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 23.4% of participants were using antihypertensive medication and 6.4% were smoking. Preliminary analyses of 24-hour blood pressure patterns and carotid intima-media thickness have previously been conducted on a subset of the cohort, with details provided in the \u2018Findings to Date\u2019 section.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The FUPEC cohort serves as a robust clinical data source and biobank that can be used for future studies and collaborative research answering, for example, questions on the aetiology, risk factors and short-term and long-term complications of pregnancies complicated by severe pre-eclampsia. Since the FUPEC cohort is integrated with routine care, there is no strict completion of data collection, allowing for flexible data acquisition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-093423","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T13:16:17Z","timestamp":1731417377000},"page":"e093423","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["FUPEC study, a prospective open-cohort on severe pre-eclampsia and cardiovascular risk factors based in the Netherlands"],"prefix":"10.1136","volume":"14","author":[{"given":"Marte F","family":"van der Bijl","sequence":"first","affiliation":[{"name":"Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Al-Hassany","sequence":"additional","affiliation":[{"name":"Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne I","family":"Wijtzes","sequence":"additional","affiliation":[{"name":"Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-9362","authenticated-orcid":false,"given":"Johannes J","family":"Duvekot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-9962","authenticated-orcid":false,"given":"Jeanine","family":"Roeters van Lennep","sequence":"additional","affiliation":[{"name":"Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"2025120520530035000_14.11.e093423.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"2025120520530035000_14.11.e093423.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"2025120520530035000_14.11.e093423.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"2025120520530035000_14.11.e093423.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"2025120520530035000_14.11.e093423.5","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316659573"},{"key":"2025120520530035000_14.11.e093423.6","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxt006"},{"key":"2025120520530035000_14.11.e093423.7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"The Lancet"},{"key":"2025120520530035000_14.11.e093423.8","doi-asserted-by":"crossref","first-page":"101127","DOI":"10.1016\/j.preghy.2024.101127","article-title":"Hypertensive disorders of pregnancy and long-term maternal cardiovascular risk: Bridging epidemiological knowledge into personalized postpartum care and follow-up","volume":"36","author":"Staff","year":"2024","journal-title":"Pregnancy Hypertens"},{"key":"2025120520530035000_14.11.e093423.9","first-page":"1","article-title":"ACOG Practice Bulletin no.202: Gestational Hypertension and Preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2025120520530035000_14.11.e093423.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70022-0"},{"key":"2025120520530035000_14.11.e093423.11","unstructured":"Nederlands Huisartsen Genootschap . NHG-standaard cardiovasculair risicomanagement. 2019. Available: https:\/\/richtlijnen.nhg.org\/standaarden\/cardiovasculair-risicomanagement"},{"key":"2025120520530035000_14.11.e093423.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.041"},{"key":"2025120520530035000_14.11.e093423.13","first-page":"822","article-title":"Status of Cardiovascular Health in US Adults and Children Using the American Heart Association\u2019s New 'Life\u2019s Essential 8","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Metrics Prevalence Estimates From the Nat Health Nutr Exam Survey (NHANES), 2013 Through 2018 Circ"},{"key":"2025120520530035000_14.11.e093423.14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10338"},{"key":"2025120520530035000_14.11.e093423.15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"2025120520530035000_14.11.e093423.16","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328363e964"},{"key":"2025120520530035000_14.11.e093423.17","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22041"},{"key":"2025120520530035000_14.11.e093423.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.11.011"},{"key":"2025120520530035000_14.11.e093423.19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.atherosclerosis.2019.11.023","article-title":"Cardiovascular health and vascular age after severe preeclampsia: A cohort study","volume":"292","author":"Benschop","year":"2020","journal-title":"Atherosclerosis"},{"key":"2025120520530035000_14.11.e093423.20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs380"},{"key":"2025120520530035000_14.11.e093423.21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.010340","article-title":"Early Onset of Coronary Artery Calcification in Women With Previous Preeclampsia","volume":"13","author":"Benschop","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025120520530035000_14.11.e093423.22","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500127740"},{"key":"2025120520530035000_14.11.e093423.23","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1080\/14767058.2021.1978067","article-title":"Preeclampsia and postpartum mental health: mechanisms and clinical implications","volume":"35","author":"Srajer","year":"2024","journal-title":"The Journal of Maternal-Fetal & Neonatal Medicine"},{"key":"2025120520530035000_14.11.e093423.24","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"2025120520530035000_14.11.e093423.25","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"2025120520530035000_14.11.e093423.26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053711","article-title":"Moving from intention to behaviour: a randomised controlled trial protocol for an app-based physical activity intervention (i2be)","volume":"12","author":"K\u00f3kai","year":"2022","journal-title":"BMJ Open"},{"key":"2025120520530035000_14.11.e093423.27","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000008"},{"key":"2025120520530035000_14.11.e093423.28","doi-asserted-by":"crossref","DOI":"10.1186\/s12905-022-01692-3","article-title":"Perceived determinants of physical activity among women with prior severe preeclampsia: a qualitative assessment","volume":"22","author":"K\u00f3kai","year":"2022","journal-title":"BMC Womens Health"},{"key":"2025120520530035000_14.11.e093423.29","doi-asserted-by":"crossref","DOI":"10.1186\/s12905-022-02004-5","article-title":"Needs and preferences of women with prior severe preeclampsia regarding app-based cardiovascular health promotion","volume":"22","author":"K\u00f3kai","year":"2022","journal-title":"BMC Womens Health"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-093423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:08Z","timestamp":1764996788000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-093423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,12]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/bmjopen-2024-093423"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-093423","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}