{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:43:21Z","timestamp":1765611801413,"version":"3.48.0"},"reference-count":75,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PHR","award":["NIHR156218"],"award-info":[{"award-number":["NIHR156218"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,6,17]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Gambling is now widely acknowledged to be a major public health (PH) issue. The Office for Health Improvement and Disparities conservatively estimated that gambling harm is associated with an annual cost of \u00a31.05\u2013\u00a31.77\u2009billion in England alone. Marionneau\n                      <jats:italic>et al<\/jats:italic>\n                      have categorised gambling harms into seven themes: (1) financial, (2) relationship\/conflict, (3) emotional and psychological (mental health), (4) health decrements (physical health), (5) employment\/education, (6) cultural and (7) criminal activity. In this understanding, gambling harms are not restricted to individual experiences: they also impact families, the wider community and society, and hence they require a whole systems, PH approach, anchored in population-level interventions to reduce harms. We aim to identify the effects of interventional PH laws and regulations on the harms associated with gambling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We limit our focus to interventional PH laws and regulations within a comprehensive search of scientific and legal databases, grey literature and books. Following Population, Intervention, Comparator, Outcome, Study, Timing inclusion criteria, evidence will be screened and appraised in Covidence by two reviewers (MF and TP). Included evidence will be analysed and synthesised using a narrative synthesis approach. Methodological quality will be appraised using the relevant risk of bias tool. Randomised controlled trials will be assessed using the Cochrane risk of bias tool (RoB2), Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) will be used for other non-randomised studies. Qualitative studies will be appraised using the EPPI reviewer software for systematic reviewing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The review protocol is registered with PROSPERO (International prospective register of systematic reviews) at the National Institute for Health Research and the Centre for Reviews and Dissemination (CRD) at the University of York (CRD42024574502). We aim to define a theory of change and produce a context-mechanism-outcome framework with relevant experts using the findings. We plan to disseminate the findings through peer-reviewed publications, meetings with relevant experts and international conference presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-093906","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T09:10:55Z","timestamp":1752657055000},"page":"e093906","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of interventional public health laws and regulations intended to reduce gambling-related harms: a realist review study protocol"],"prefix":"10.1136","volume":"15","author":[{"given":"Michelle","family":"Fisher","sequence":"first","affiliation":[{"name":"University of Birmingham College of Medicine and Health, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Piper","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Mavi","sequence":"additional","affiliation":[{"name":"University of Birmingham College of Medicine and Health, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Nambiar","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-9578","authenticated-orcid":false,"given":"Priyanka Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Birmingham College of Medicine and Health, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelle","family":"Kirby","sequence":"additional","affiliation":[{"name":"University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Melendez-Torres","sequence":"additional","affiliation":[{"name":"University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-1370","authenticated-orcid":false,"given":"Paul","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Social Policy, Sociology and Criminology, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Fewell","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joht Singh","family":"Chandan","sequence":"additional","affiliation":[{"name":"University of Birmingham College of Medicine and Health, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Bedford","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"2025121223385125000_15.7.e093906.1","unstructured":"Public Health England . 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