{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:25:49Z","timestamp":1790126749043,"version":"4.0.1"},"reference-count":40,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["No.2022JJ80047 and 2024JJ5621"],"award-info":[{"award-number":["No.2022JJ80047 and 2024JJ5621"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81903663"],"award-info":[{"award-number":["No.81903663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changsha Natural Science Foundation of China"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,7,2]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The causal relationship between sleep characteristics and aortic aneurysm and dissection (AAD) is little known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this two-sample Mendelian randomisation (MR) study, we selected seven sleep-related traits (sleep duration, getting up in the morning, chronotype, nap during day, insomnia, snoring, and narcolepsy) from published genome-wide association study (GWAS)-related genetic variants as instrumental variables. Causality was assessed by two-sample MR analysis using inverse-variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple model. Horizontal pleiotropy was tested using MR-Egger regression and MR-polytropic residuals and outliers, and heterogeneity was calculated by Cochran\u2019s Q test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no evidence of causality among sleep duration (IVW: OR=0.759, 95%\u2009CI: 0.489 to 1.177, p=0.218), getting up in the morning (IVW: OR=1.148, 95%\u2009CI: 0.768 to 1.716, p=0.502), chronotype (IVW: OR=0.960, 95%\u2009CI: 0.796 to 1.158, p=0.670), nap during day (IVW: OR=1.248, 95%\u2009CI: 0.771 to 2.020, p=0.367), sleeplessness\/insomnia (IVW: OR=1.280, 95%\u2009CI: 0.678 to 2.414, p=0.447), snoring (IVW: OR=0.963, 95%\u2009CI: 0.770 to 1.203, p=0.738), narcolepsy (IVW: OR=1.025, 95%\u2009CI: 0.367 to 2.863, p=0.962) and aortic aneurysm. Moreover, there was no evidence to suggest a causal relationship among sleep traits and abdominal aneurysm, thoracic aneurysm and aortic dissection. Sensitivity analyses, including leave-one-out, horizontal pleiotropy and heterogeneity tests, indicated that our results were robust and reliable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, our study found no genetic evidence of a causal relationship between sleep characteristics and AAD. Large-scale randomised controlled trial experiments are also needed to further verify the causal relationship between sleep and AAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-095098","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:45:27Z","timestamp":1752464727000},"page":"e095098","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between sleep characteristics and aortic aneurysm\/dissection: a two-sample Mendelian randomisation study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-4954","authenticated-orcid":false,"given":"Yi-Fan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya Hospital Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Guo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Hypothalamic Pituitary Research Centre, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-7376","authenticated-orcid":false,"given":"Wenjing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya Hospital Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"2025121403150593000_15.7.e095098.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312436"},{"key":"2025121403150593000_15.7.e095098.2","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X16666201014142930","article-title":"Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances","volume":"17","author":"Sayed","year":"2021","journal-title":"Curr Cardiol Rev"},{"key":"2025121403150593000_15.7.e095098.3","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01325-7","article-title":"The mechanism and therapy of aortic aneurysms","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2025121403150593000_15.7.e095098.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.004"},{"key":"2025121403150593000_15.7.e095098.5","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1093\/eurheartj\/ehab170","article-title":"Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank","volume":"42","author":"Ai","year":"2021","journal-title":"Eur Heart J"},{"key":"2025121403150593000_15.7.e095098.6","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-104046"},{"key":"2025121403150593000_15.7.e095098.7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jsmc.2021.05.001","article-title":"Sleep and Cardiovascular Risk","volume":"16","author":"Korostovtseva","year":"2021","journal-title":"Sleep Med Clin"},{"key":"2025121403150593000_15.7.e095098.8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz849"},{"key":"2025121403150593000_15.7.e095098.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000988"},{"key":"2025121403150593000_15.7.e095098.10","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.7150\/ijbs.34888","article-title":"Obstructive sleep apnea syndrome promotes the progression of aortic dissection via a ROS- HIF-1\u03b1-MMPs associated pathway","volume":"15","author":"Liu","year":"2019","journal-title":"Int J Biol Sci"},{"key":"2025121403150593000_15.7.e095098.11","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03322-2020","article-title":"Obstructive sleep apnoea and the progression of thoracic aortic aneurysm: a prospective cohort study","volume":"57","author":"Gaisl","year":"2021","journal-title":"Eur Respir J"},{"key":"2025121403150593000_15.7.e095098.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00029315"},{"key":"2025121403150593000_15.7.e095098.13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010098"},{"key":"2025121403150593000_15.7.e095098.14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: A review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"key":"2025121403150593000_15.7.e095098.15","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"2025121403150593000_15.7.e095098.16","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"2025121403150593000_15.7.e095098.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2022.02.008"},{"key":"2025121403150593000_15.7.e095098.18","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSMC.2017.01.005"},{"key":"2025121403150593000_15.7.e095098.19","doi-asserted-by":"crossref","first-page":"H29","DOI":"10.1152\/ajpheart.00607.2020","article-title":"Sleep deprivation and endothelial function: reconciling seminal evidence with recent perspectives","volume":"320","author":"Cherubini","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2025121403150593000_15.7.e095098.20","doi-asserted-by":"crossref","first-page":"E21","DOI":"10.1097\/JCN.0000000000000485","article-title":"Endothelial Dysfunction is Related to Glycemic Variability and Quality and Duration of Sleep in Adults With Type 1 Diabetes","volume":"33","author":"Farabi","year":"2018","journal-title":"J Cardiovasc Nurs"},{"key":"2025121403150593000_15.7.e095098.21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.atherosclerosis.2017.08.001","article-title":"Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation","volume":"265","author":"Bain","year":"2017","journal-title":"Atherosclerosis"},{"key":"2025121403150593000_15.7.e095098.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.04.024"},{"key":"2025121403150593000_15.7.e095098.23","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051708","article-title":"Considerations for Maximizing the Exercise \u201cDrug\u201d to Combat Insulin Resistance: Role of Nutrition, Sleep, and Alcohol","volume":"13","author":"Remchak","year":"2021","journal-title":"Nutrients"},{"key":"2025121403150593000_15.7.e095098.24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056546"},{"key":"2025121403150593000_15.7.e095098.25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/CIRCULATIONAHA.121.058133","article-title":"Taming Hypertension to Prevent Aortic Dissection: Universal Recognition of a \u201cNew Normal\u201d Blood Pressure?","volume":"145","author":"Nienaber","year":"2022","journal-title":"Circulation"},{"key":"2025121403150593000_15.7.e095098.26","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/eurjpc\/zwac205","article-title":"Dose-dependent relationship of blood pressure and glycaemic status with risk of aortic dissection and aneurysm","volume":"29","author":"Suzuki","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"2025121403150593000_15.7.e095098.27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1177\/1708538118766102","article-title":"Obstructive sleep apnea and risk of aortic dissection: A meta-analysis of observational studies","volume":"26","author":"Zhou","year":"2018","journal-title":"Vascular"},{"key":"2025121403150593000_15.7.e095098.28","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10049","article-title":"Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis","volume":"8","author":"Zhai","year":"2022","journal-title":"Heliyon"},{"key":"2025121403150593000_15.7.e095098.29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jcma.2015.10.014","article-title":"Sleep apnea and risk of aortic dissection: A nonrandomized, pair-matched cohort study","volume":"79","author":"Teng","year":"2016","journal-title":"J Chin Med Assoc"},{"key":"2025121403150593000_15.7.e095098.30","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/ehjci\/jeae140","article-title":"The aortic paradox: a nationwide analysis of 523 994 individual echocardiograms exploring fatal aortic dissection","volume":"25","author":"Paratz","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025121403150593000_15.7.e095098.31","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000118013.72016.ea"},{"key":"2025121403150593000_15.7.e095098.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00472-6"},{"key":"2025121403150593000_15.7.e095098.33","doi-asserted-by":"crossref","unstructured":"Wu H , Xie C , Wang R , et al . Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level. Front Pharmacol 2022;13. doi:10.3389\/fphar.2022.1095757","DOI":"10.3389\/fphar.2022.1095757"},{"key":"2025121403150593000_15.7.e095098.34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308765"},{"key":"2025121403150593000_15.7.e095098.35","doi-asserted-by":"publisher","DOI":"10.1038\/ng.934"},{"key":"2025121403150593000_15.7.e095098.36","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.6"},{"key":"2025121403150593000_15.7.e095098.37","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"2025121403150593000_15.7.e095098.38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"2025121403150593000_15.7.e095098.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"2025121403150593000_15.7.e095098.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-095098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:15:16Z","timestamp":1765710916000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-095098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,13]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bmjopen-2024-095098"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-095098","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}