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Patients filled an anonymous two-page questionnaire on various socio-demographic, medical characteristics and their satisfaction with GP communication. Structural equation modelling evaluated associations of various patient characteristics, including psychosocial problems with GP communication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>General practices in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 813 patients from 12 GP practices participated. The survey was conducted in summer 2020 during a COVID-19 lockdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated response rate was 24.1%. The prevalence of psychosocial problems in the sample was 30%. The three most frequent problems were excessive stress at work (19%), financial problems\/debts (9%) and loneliness (8%). Most patients agreed that their GP takes their problems seriously (71%), feeling comfortable talking about sensitive things (66%), having enough space in communication (62%) and being asked by their GP about personal strains (53%). Higher social support, preference to solve one\u2019s problem without GP help, higher age and better health status predicted more satisfaction with physician\u2013patient communication, while the number of psychosocial problems, gender, years with physician, chronic stress and depression had no influence. According to the Bentler Comparative Fit Index, the pooled structural equation model had a 97.6% better fit than the corresponding model without covariate effects.<\/jats:p><jats:p>Higher social support, preference to solve one\u2019s problem without GP help, higher age and better health status but not the number of psychosocial problems predicted more satisfaction with physician\u2013patient communication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GPs should be aware of the high occurrence of patients\u2019 psychosocial problems and actively address patients\u2019 social support and self-management preferences which influence patients\u2019 satisfaction with GP communication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>The General Practice Care-1 study was registered in the German Clinical Trials Register 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