{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:45:54Z","timestamp":1794329154623,"version":"4.9.0"},"reference-count":26,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,4,25]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To assess the effects of oral dydrogesterone on the recurrence rate of endometrial polyps (EPs) and abnormal uterine bleeding (AUB) symptoms after transcervical resection of polyps (TCRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A randomised, parallel, open-label, multicentre study will be conducted across 12 hospitals in China, including general and women\u2019s specialty hospitals. In this study, we will recruit female patients aged 18\u201346 years diagnosed with EPs using transvaginal ultrasonography during two menstrual cycles. Eligible participants who have not received other oestrogen or progesterone treatments will be randomly assigned in a 1:1 ratio to either an intervention or control group. All participants will undergo TCRP, with the time between randomisation and surgery not exceeding 14 days. The intervention group will receive oral dydrogesterone for three menstrual cycles, whereas the control group will receive no hormonal treatment. The primary outcome is the recurrence rate of EPs, which will be evaluated using follow-up transvaginal ultrasonography at 1, 3, 6, 12, 18 and 24 months postsurgery. Secondary outcomes include assessment of AUB and menstrual status. For statistical analyses, a multivariate regression will be used to adjust for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study protocol adheres to the Declaration of Helsinki and has been approved by the Women\u2019s Hospital, School of Medicine, Zhejiang University (IRB-20240077-R). All participants in the trial will provide written informed consent. The study findings will be published in peer-reviewed journals and presented at academic conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ChiCTR2400083097.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-096896","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:15:32Z","timestamp":1746602132000},"page":"e096896","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Dydrogesterone for preventing endometrial polyp recurrence after transcervical resection of polyps: protocol for a multicentre randomised controlled trial in China"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-9408","authenticated-orcid":false,"given":"Yuan","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-4429","authenticated-orcid":false,"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taizhou First People\u2019s Hospital, Taizhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shaoxing Women and Children\u2019s Hospital, Shaoxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Ningbo University, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-4045","authenticated-orcid":false,"given":"Xiufeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"2025121409322950000_15.5.e096896.1","first-page":"1","article-title":"AAGL practice report: Practice guidelines on intrauterine adhesions developed in collaboration with the European Society of Gynaecological Endoscopy (ESGE)","volume":"14","author":"Abbott","year":"2017","journal-title":"Gynecol Surg"},{"key":"2025121409322950000_15.5.e096896.2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.jmig.2019.11.023","article-title":"Prevention of Benign Endometrial Polyp Recurrence Using a Levonorgestrel-releasing Intrauterine System in Premenopausal Patients: A Retrospective Cohort Study","volume":"27","author":"Wang","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"2025121409322950000_15.5.e096896.3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052557","article-title":"Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps","volume":"25","author":"Chiu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025121409322950000_15.5.e096896.4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/13645706.2021.1948867","article-title":"Endometrial polyps: diagnosis and treatment options \u2013 a review of literature","volume":"30","author":"Raz","year":"2021","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"2025121409322950000_15.5.e096896.5","doi-asserted-by":"crossref","first-page":"102402","DOI":"10.1016\/j.jogc.2024.102402","article-title":"Guideline No. 447: Diagnosis and Management of Endometrial Polyps","volume":"46","author":"Bougie","year":"2024","journal-title":"J Obstet Gynaecol Can"},{"key":"2025121409322950000_15.5.e096896.6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejogrb.2021.03.017","article-title":"Endometrial polyps. 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